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. 2016 May 11;1(3):e00036-16. doi: 10.1128/mSphere.00036-16

TABLE 1 .

Metadata for B. pertussis isolates collected during the California 2010 and Vermont 2012 statewide epidemics and vaccine strains that were selected for whole-genome sequencingl

Isolate Location Yr of
isolation		 Age at
symptom
onset		 Vaccination
status		 PFGE
type		 MLVAa prnb ptxPb ptxAb fimHb,c prn
genotype		 Prn
productiond
H374 CA 2010 Infant UV CDC002 16 2 3 1 1 WT prn +
H375e CA 2010 Infant UV CDC268 186 1 1 2 1 Del nt 26-109f −
H378 CA 2010 Infant UV CDC253 27 2 3 1 1 IS481::240 Fwdg −
H379 CA 2010 Infant UV CDC046 27 2 3 1 2 WT prn +
H380e CA 2010 Infant UV CDC013 27 2 3 1 2 WT prn +
H489 CA 2010 Infant UV CDC082 27 2 3 1 2 WT prn +
H542e CA 2010 Infant UV CDC269 27 2 3 1 1 WT prn +
H559e CA 2010 Infant UV CDC253 27 2 3 1 1 IS481::240 Fwdg −
H561 CA 2010 Infant UV CDC170 16 2 3 1 2 WT prn +
H563e CA 2010 Infant ≥1 dose CDC271 27 2 3 1 2 WT prn +
H564 CA 2010 Child UV CDC013 27 2 3 1 2 WT prn +
H622 CA 2010 Infant UV CDC217 27 2 3 1 1 WT prn +
H627 CA 2010 Infant UV CDC217 27 2 3 1 1 WT prn +
H788 VT 2011 Infant UV CDC046 128 2 3 1 2 WT prn +
I669 VT 2011 Adult UV CDC013 27 2 3 1 2 WT prn +
I468 VT 2012 Child UV CDC002 27 2 3 1 1 SC @ nt 1273 −
I469 VT 2012 Child ≥1 dose CDC342 27 2 3 1 2 IS481::1613 Revh −
I472 VT 2012 Adolescent UV CDC046 27 2 3 1 2 IS481::1613 Revh −
I475 VT 2012 Adult UV CDC237 27 2 3 1 1 IS481::1613 Fwdi −
I476 VT 2012 Adolescent UTD CDC300 27 2 3 1 1 IS481::1613 Fwdi −
I480 VT 2012 Child ≥1 dose CDC217 27 2 3 1 1 WT prn +
I483 VT 2012 Infant UTD CDC237 27 2 3 1 1 IS481::1613 Fwdi −
I488 VT 2012 Child ≥1 dose CDC343 27 2 3 1 1 IS481::1613 Fwdi −
I496 VT 2012 Child UTD CDC343 27 2 3 1 1 IS481::1613 Fwdi −
I498 VT 2012 Adult ≥1 dose CDC253 27 2 3 1 1 IS481::240 Revj −
I517 VT 2012 Child ≥1 dose CDC344 27 2 3 1 1 IS481::1613 Fwdi −
I518 VT 2012 Child UTD CDC002 27 2 3 1 1 SC @ nt 1273 −
I521 VT 2012 Child ≥1 dose CDC237 27 2 3 1 1 IS481::1613 Fwdi −
I538 VT 2012 Child UNK CDC002 27 2 3 1 1 prnP (–74 nt)k −
I539 VT 2012 Child UTD CDC002 27 2 3 1 1 prnP (–74 nt)k −
I646 VT 2012 Child UV CDC274 27 2 3 1 1 WT prn +
I656 VT 2012 Child UTD CDC010 27 2 3 1 1 WT prn +
I707 VT 2012 Child UTD CDC253 27 2 3 1 1 WT prn +
C393 China 1951 UNK NA CDC052 UNK 1 1 2 1 WT prn +
E476 Japan 1954 UNK NA CDC232 38 1 1 2 1 WT prn +
a

MLVA type is defined by the repeat counts for VNTR1, VNTR3, VNTR4, VNTR5, and VNTR6 (21).

b

Single-copy locus (21).

c

Formerly referred to as fim3.

d

Based on enzyme-linked immunosorbent assay.

e

Fatal cases.

f

Signal sequence deletion (nt 26 to 109).

g

IS481 forward insertion at nt 240.

h

IS481 reverse insertion at nt 1613.

i

IS481 forward insertion at nt 1613.

j

IS481 reverse insertion at nt 240.

k

Promoter disruption (–74 nt), previously identified as promoter inversion (11, 15).

l

Abbreviations: MLVA, multilocus variable-number tandem-repeat analysis; CA, California; VT, Vermont; nt, nucleotide; UTD, up to date; UV, unvaccinated; UNK, unknown; WT, wild-type; SC, stop codon; NA, not applicable.