TABLE 3 .

Unique SNPs in virulence-related genes^a of B. pertussis epidemic isolates compared to E476 (Tohama I)

Gene	Isolate(s)	SNP location	Region characteristic	Amino acid change	Protein expressed? (49)	Reference(s)
bapC	H374	655 A→G	String of 2 G’s	219 Asp→Gly	Unknown	This study
bfrD	H564	1634 G→A	GC-rich region	545 Ser→Asn	Unknown	This study
bipA	H563	1070 G→T	GC-rich region	357 Arg→Leu	Unknown	This study
brkA	I646	640 C→T	GC-rich region	214 Pro→Ser	Unknown	This study
bscC	H375	1677 G→A	String of 2 A’s	NAb	Yes	This study; 49
bvgR	C393	36 C→T	String of 3 T’s	NA	Unknown	This study; 23
bvgS	All epidemic isolates, C393	2113 A→G	GC-rich region	705 Lys→Glu	Yes	47, 49, 50, 51, 52
fimD	All epidemic isolates, C393	356 T→C	GC-rich region	119 Phe→Ser	Yes	47, 49, 50, 53, 54
ptxB	All epidemic isolates	133 G→A	GC-rich region	45 Gly→Ser	Yes	47, 49, 50, 55
ptxC	All epidemic isolates except H375	681 C→T	String of 2 T’s	NA	Yes	47, 49, 56

^aDoes not include previously identified SNPs associating with MLST typing loci.

^bNA, not applicable.