Table 2.

Reproductive factors and CHD adjusted for established CHD risk factors among WHI OS participants.

	Established Risk Factors + Independently significant reproductive variables (p≤0.10)			Established Risk Factors + Reproductive variables: Final Model
	HR	95% CI	p	HR	95% CI	p
Age at enrollment	1.07	1.07, 1.08	<.0001	1.07	1.07, 1.08	<.0001
History of high cholesterol requiring pills			<.0001			<.0001
No	1.00			1.00
Yes	1.37	1.28, 1.48		1.37	1.28, 1.48
Current hypertension			<.0001			<.0001
No	1.00			1.00
Yes	1.49	1.40, 1.59		1.49	1.39, 1.58
Log Systolic BP	6.01	4.80, 7.51	<.0001	5.99	4.80, 7.49	<.0001
Current smoker			<.0001			<.0001
No	1.00			1.00
Yes	1.82	1.64, 2.03		1.83	1.64, 2.03
Diabetes ever			<.0001			<.0001
No	1.00			1.00
Yes	2.62	2.39, 2.86		2.62	2.40, 2.87
Irregular menstrual cycle			0.08
Yes	1.09	0.98, 1.21
No
Sometimes regular, sometimes irregular	1.09	0.99, 1.20
Ever pregnant			0.44
No	1.00
Yes	0.92	0.75, 1.13
Number of live births			0.65
None	1.00
1–4	1.29	0.57, 2.90
≥5	1.25	0.55, 2.82
Age at first birth			<.0001			<.0001
No pregnancy lasting at least 6 months	1.23	0.53, 2.82		1.02	0.92, 1.13
<20	1.43	1.29, 1.57		1.42	1.29, 1.56
20–24	1.21	1.13, 1.30		1.21	1.13, 1.30
≥25	1.00			1.00
Number of still births			0.03			0.04
None	1.00			1.00
1	1.18	1.03, 1.37		1.18	1.02, 1.35
>1	1.24	0.90, 1.72		1.24	0.89, 1.71
Number of miscarriages			<.0001			<.0001
None	1.00			1.00
1	1.12	1.04, 1.20		1.11	1.03, 1.20
2–4	1.25	1.14, 1.37		1.24	1.13, 1.36
5+	1.39	1.04, 1.86		1.39	1.04, 1.86
Breastfed for ≥ 1 month			0.001			0.001
No	1.00			1.00
Yes	0.90	0.85, 0.96		0.90	0.85, 0.96