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. 1992 Feb;55(2):153–155. doi: 10.1136/jnnp.55.2.153

HTLV-I infection and neurological disease in Rio de Janeiro.

A de Q Araujo 1, A Ali 1, A Newell 1, A G Dalgleish 1, P Rudge 1
PMCID: PMC488982  PMID: 1538224

Abstract

Fifty patients with chronic neurological diseases attending a clinic in Rio de Janeiro, Brazil, were examined for evidence of HTLV-I infection. Fifteen of 27 with progressive paraparesis of obscure origin had antibodies to HTLV-I in high titre in their serum samples, and 10 of 13 studied had antibodies in their cerebrospinal fluid. The clinical features of the antibody positive patients were similar to those of patients with HTLV-I associated myelopathy from other countries except that half of the Brazilian patients were white. Seven patients had multiple sclerosis and one of these had antibodies to HTLV-I in the serum. None of the eight patients with motor neuron disease and four with polymyositis had HTLV-I antibodies in their serum samples.

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Selected References

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  1. Andrada-Serpa M. J., Tosswill J., Schor D., Linhares D., Dobbin J., Pereira M. S. Seroepidemiologic survey for antibodies to human retroviruses in human and non-human primates in Brazil. Int J Cancer. 1989 Sep 15;44(3):389–393. doi: 10.1002/ijc.2910440302. [DOI] [PubMed] [Google Scholar]
  2. Bhigjee A. I., Kelbe C., Haribhai H. C., Windsor I. M., Hoffmann M. H., Modi G., Bill P. L., Becker W. B., Singh B., Engelbrecht S. Myelopathy associated with human T cell lymphotropic virus type I (HTLV-I) in natal, South Africa. A clinical and investigative study in 24 patients. Brain. 1990 Oct;113(Pt 5):1307–1320. doi: 10.1093/brain/113.5.1307. [DOI] [PubMed] [Google Scholar]
  3. Castro L. H., Chaves C. J., Callegaro D., Nóbrega J. P., Scaff M. HTLV-I associated myelopathy in Brazil: a preliminary report. Arq Neuropsiquiatr. 1989 Dec;47(4):501–502. doi: 10.1590/s0004-282x1989000400021. [DOI] [PubMed] [Google Scholar]
  4. Cortes E., Detels R., Aboulafia D., Li X. L., Moudgil T., Alam M., Bonecker C., Gonzaga A., Oyafuso L., Tondo M. HIV-1, HIV-2, and HTLV-I infection in high-risk groups in Brazil. N Engl J Med. 1989 Apr 13;320(15):953–958. doi: 10.1056/NEJM198904133201501. [DOI] [PubMed] [Google Scholar]
  5. Costa C. M., Salgueiro M. R., Carton H., Do Vale O. C., De Arruda A. M. Tropical spastic paraparesis in Northeastern Brazil. Arq Neuropsiquiatr. 1989 Jun;47(2):134–138. doi: 10.1590/s0004-282x1989000200002. [DOI] [PubMed] [Google Scholar]
  6. Cruickshank J. K., Rudge P., Dalgleish A. G., Newton M., McLean B. N., Barnard R. O., Kendall B. E., Miller D. H. Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. Brain. 1989 Aug;112(Pt 4):1057–1090. doi: 10.1093/brain/112.4.1057. [DOI] [PubMed] [Google Scholar]
  7. Dalgleish A. G., Fazakerley J. K., Webb H. E. Do human T-lymphotrophic viruses (HTLVs) and other enveloped viruses induce autoimmunity in multiple sclerosis? Neuropathol Appl Neurobiol. 1987 Jul-Aug;13(4):241–250. doi: 10.1111/j.1365-2990.1987.tb00064.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dalgleish A., Richardson J., Matutes E., Cruickshank K., Newell A., Sinclair A., Thorpe R., Brasher M., Weber J., Catovsky D. HTLV-1 infection in tropical spastic paraparesis: lymphocyte culture and serologic response. AIDS Res Hum Retroviruses. 1988 Dec;4(6):475–485. doi: 10.1089/aid.1988.4.475. [DOI] [PubMed] [Google Scholar]
  9. Gout O., Gessain A., Bolgert F., Saal F., Tournier-Lasserve E., Lasneret J., Caudie C., Brunet P., De-Thé G., Lhermitte F. Chronic myelopathies associated with human T-lymphotropic virus type I. A clinical, serologic, and immunovirologic study of ten patients in France. Arch Neurol. 1989 Mar;46(3):255–260. doi: 10.1001/archneur.1989.00520390021009. [DOI] [PubMed] [Google Scholar]
  10. KURTZKE J. F. FURTHER NOTES ON DISABILITY EVALUATION IN MULTIPLE SCLEROSIS, WITH SCALE MODIFICATIONS. Neurology. 1965 Jul;15:654–661. doi: 10.1212/wnl.15.7.654. [DOI] [PubMed] [Google Scholar]
  11. Kajiyama W., Kashiwagi S., Ikematsu H., Hayashi J., Nomura H., Okochi K. Intrafamilial transmission of adult T cell leukemia virus. J Infect Dis. 1986 Nov;154(5):851–857. doi: 10.1093/infdis/154.5.851. [DOI] [PubMed] [Google Scholar]
  12. Kayembe K., Goubau P., Desmyter J., Vlietinck R., Carton H. A cluster of HTLV-1 associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution. J Neurol Neurosurg Psychiatry. 1990 Jan;53(1):4–10. doi: 10.1136/jnnp.53.1.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kitagawa T., Fujishita M., Taguchi H., Miyoshi I., Tadokoro H. Antibodies to HTLV-I in Japanese immigrants in Brazil. JAMA. 1986 Nov 7;256(17):2342–2342. [PubMed] [Google Scholar]
  14. Morgan O. S., Montgomery R. D., Rodgers-Johnson P. The myeloneuropathies of Jamaica: an unfolding story. Q J Med. 1988 Apr;67(252):273–281. [PubMed] [Google Scholar]
  15. Newton M., Cruickshank K., Miller D., Dalgleish A., Rudge P., Clayden S., Moseley I. Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis. Lancet. 1987 Feb 21;1(8530):415–416. doi: 10.1016/s0140-6736(87)90120-6. [DOI] [PubMed] [Google Scholar]
  16. Osame M., Usuku K., Izumo S., Ijichi N., Amitani H., Igata A., Matsumoto M., Tara M. HTLV-I associated myelopathy, a new clinical entity. Lancet. 1986 May 3;1(8488):1031–1032. doi: 10.1016/s0140-6736(86)91298-5. [DOI] [PubMed] [Google Scholar]
  17. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I. Science. 1989 Nov 10;246(4931):821–824. [PubMed] [Google Scholar]
  18. Poiesz B. J., Ruscetti F. W., Gazdar A. F., Bunn P. A., Minna J. D., Gallo R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415–7419. doi: 10.1073/pnas.77.12.7415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Reddy E. P., Sandberg-Wollheim M., Mettus R. V., Ray P. E., DeFreitas E., Koprowski H. Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients. Science. 1989 Jan 27;243(4890):529–533. doi: 10.1126/science.2536193. [DOI] [PubMed] [Google Scholar]
  20. Román G. C., Román L. N. Tropical spastic paraparesis. A clinical study of 50 patients from Tumaco (Colombia) and review of the worldwide features of the syndrome. J Neurol Sci. 1988 Oct;87(1):121–138. doi: 10.1016/0022-510x(88)90059-7. [DOI] [PubMed] [Google Scholar]
  21. Saxinger C., Gallo R. C. Methods in laboratory investigation. Application of the indirect enzyme-linked immunosorbent assay microtest to the detection and surveillance of human t cell leukemia-lymphoma virus. Lab Invest. 1983 Sep;49(3):371–377. [PubMed] [Google Scholar]
  22. Shibasaki H., Endo C., Kuroda Y., Kakigi R., Oda K., Komine S. Clinical picture of HTLV-I associated myelopathy. J Neurol Sci. 1988 Oct;87(1):15–24. doi: 10.1016/0022-510x(88)90050-0. [DOI] [PubMed] [Google Scholar]
  23. Thorpe R., Brasher M. D., Bird C. R., Garrett A. J., Jacobs J. P., Minor P. D., Schild G. C. An improved immunoblotting procedure for the detection of antibodies against HIV. J Virol Methods. 1987 May;16(1-2):87–96. doi: 10.1016/0166-0934(87)90034-6. [DOI] [PubMed] [Google Scholar]
  24. Usuku K., Nishizawa M., Matsuki K., Tokunaga K., Takahashi K., Eiraku N., Suehara M., Juji T., Osame M., Tabira T. Association of a particular amino acid sequence of the HLA-DR beta 1 chain with HTLV-I-associated myelopathy. Eur J Immunol. 1990 Jul;20(7):1603–1606. doi: 10.1002/eji.1830200729. [DOI] [PubMed] [Google Scholar]
  25. Wucherpfennig K. W., Ota K., Endo N., Seidman J. G., Rosenzweig A., Weiner H. L., Hafler D. A. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25;248(4958):1016–1019. doi: 10.1126/science.1693015. [DOI] [PubMed] [Google Scholar]

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