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. 1992 Feb;55(2):162–165. doi: 10.1136/jnnp.55.2.162

Amyloid myopathy presenting with respiratory failure.

J Ashe 1, C O Borel 1, G Hart 1, R L Humphrey 1, D A Derrick 1, R W Kuncl 1
PMCID: PMC488985  PMID: 1538226

Abstract

Amyloidosis is a rare cause of myopathy. Its prominent or presenting feature may be respiratory failure. Physiological measurement of transdiaphragmatic pressure and biopsy specimens of muscle show the pathological mechanism to be diaphragm weakness due to amyloid infiltration of the diaphragm rather than parenchymal lung involvement. Thus amyloid myopathy even without the typical macroglossia and muscle pseudohypertrophy should be considered as one of the neurological causes of respiratory failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumbergs P. C., Byrne E., Kakulas B. A. Polymyositis presenting with respiratory failure. J Neurol Sci. 1984 Aug;65(2):221–229. doi: 10.1016/0022-510x(84)90086-8. [DOI] [PubMed] [Google Scholar]
  2. Fromm G. B., Wisdom P. J., Block A. J. Amyotrophic lateral sclerosis presenting with respiratory failure. Diaphragmatic paralysis and dependence on mechanical ventilation in two patients. Chest. 1977 May;71(5):612–614. doi: 10.1378/chest.71.5.612. [DOI] [PubMed] [Google Scholar]
  3. González-Cueto D. M., Rigoli M., Gioseffi L. M., Lancelle B., Martínez A. Diffuse pulmonary amyloidosis. Am J Med. 1970 May;48(5):668–670. doi: 10.1016/0002-9343(70)90020-3. [DOI] [PubMed] [Google Scholar]
  4. Jennekens F. G., Wokke J. H. Proximal weakness of the extremities as main feature of amyloid myopathy. J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1353–1358. doi: 10.1136/jnnp.50.10.1353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. King R. J. Pulmonary surfactant. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul;53(1):1–8. doi: 10.1152/jappl.1982.53.1.1. [DOI] [PubMed] [Google Scholar]
  6. Kuncl R. W., Cornblath D. R., Avila O., Duncan G. Electrodiagnosis of human colchicine myoneuropathy. Muscle Nerve. 1989 May;12(5):360–364. doi: 10.1002/mus.880120504. [DOI] [PubMed] [Google Scholar]
  7. Mier-Jedrzejowicz A., Brophy C., Moxham J., Green M. Assessment of diaphragm weakness. Am Rev Respir Dis. 1988 Apr;137(4):877–883. doi: 10.1164/ajrccm/137.4.877. [DOI] [PubMed] [Google Scholar]
  8. Ringel S. P., Claman H. N. Amyloid-associated muscle pseudohypertrophy. Arch Neurol. 1982 Jul;39(7):413–417. doi: 10.1001/archneur.1982.00510190031009. [DOI] [PubMed] [Google Scholar]
  9. Rosenow E. C., 3rd, Engel A. G. Acid maltase deficiency in adults presenting as respiratory failure. Am J Med. 1978 Mar;64(3):485–491. doi: 10.1016/0002-9343(78)90235-8. [DOI] [PubMed] [Google Scholar]
  10. Santiago R. M., Scharnhorst D., Ratkin G., Crouch E. C. Respiratory muscle weakness and ventilatory failure in AL amyloidosis with muscular pseudohypertrophy. Am J Med. 1987 Jul;83(1):175–178. doi: 10.1016/0002-9343(87)90516-x. [DOI] [PubMed] [Google Scholar]
  11. Streeten E. A., de la Monte S. M., Kennedy T. P. Amyloid infiltration of the diaphragm as a cause of respiratory failure. Chest. 1986 May;89(5):760–762. doi: 10.1378/chest.89.5.760. [DOI] [PubMed] [Google Scholar]
  12. Whitaker J. N., Hashimoto K., Quinones M. Skeletal muscle pseudohypertrophy in primary amyloidosis. Neurology. 1977 Jan;27(1):47–54. doi: 10.1212/wnl.27.1.47. [DOI] [PubMed] [Google Scholar]

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