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. 1992 Apr;55(4):247–250. doi: 10.1136/jnnp.55.4.247

Endorphins: the basis of pleasure?

C H Hawkes
PMCID: PMC489033  PMID: 1316428

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson R. L. Opioid regulation of food intake and body weight in humans. Fed Proc. 1987 Jan;46(1):178–182. [PubMed] [Google Scholar]
  2. BARCHAS J. D., FREEDMAN D. X. BRAIN AMINES: RESPONSE TO PHYSIOLOGICAL STRESS. Biochem Pharmacol. 1963 Oct;12:1232–1235. doi: 10.1016/0006-2952(63)90101-1. [DOI] [PubMed] [Google Scholar]
  3. Belluzzi J. D., Stein L. Enkephalin may mediate euphoria and drive-reduction reward. Nature. 1977 Apr 7;266(5602):556–558. doi: 10.1038/266556a0. [DOI] [PubMed] [Google Scholar]
  4. Blum K., Hamilton M. G., Hirst M., Wallace J. E. Putative role of isoquinoline alkaloids in alcoholism: a link to opiates. Alcohol Clin Exp Res. 1978 Apr;2(2):113–120. doi: 10.1111/j.1530-0277.1978.tb04710.x. [DOI] [PubMed] [Google Scholar]
  5. Bortz W. M., 2nd, Angwin P., Mefford I. N., Boarder M. R., Noyce N., Barchas J. D. Catecholamines, dopamine, and endorphin levels during extreme exercise. N Engl J Med. 1981 Aug 20;305(8):466–467. [PubMed] [Google Scholar]
  6. Brooks S., Burrin J., Cheetham M. E., Hall G. M., Yeo T., Williams C. The responses of the catecholamines and beta-endorphin to brief maximal exercise in man. Eur J Appl Physiol Occup Physiol. 1988;57(2):230–234. doi: 10.1007/BF00640668. [DOI] [PubMed] [Google Scholar]
  7. Clow A., Topham A., Saunders J. B., Murray R., Sandler M. The role of salsolinol in alcohol intake and withdrawal. Prog Clin Biol Res. 1985;183:101–113. [PubMed] [Google Scholar]
  8. Colt E. W., Wardlaw S. L., Frantz A. G. The effect of running on plasma beta-endorphin. Life Sci. 1981 Apr 6;28(14):1637–1640. doi: 10.1016/0024-3205(81)90319-2. [DOI] [PubMed] [Google Scholar]
  9. Davis V. E., Walsh M. J. Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Science. 1970 Feb 13;167(3920):1005–1007. doi: 10.1126/science.167.3920.1005. [DOI] [PubMed] [Google Scholar]
  10. Davis W. M., Smith S. G., Khalsa J. H. Noradrenergic role in the self-administration of morphine or amphetamine. Pharmacol Biochem Behav. 1975 May-Jun;3(3):477–484. doi: 10.1016/0091-3057(75)90059-3. [DOI] [PubMed] [Google Scholar]
  11. Dum J., Gramsch C., Herz A. Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food. Pharmacol Biochem Behav. 1983 Mar;18(3):443–447. doi: 10.1016/0091-3057(83)90467-7. [DOI] [PubMed] [Google Scholar]
  12. Facchinetti F., Giovannini C., Barletta C., Petraglia F., Buzzetti R., Burla F., Lazzari R., Genazzani A. R., Scavo D. Hyperendorphinemia in obesity and relationships to affective state. Physiol Behav. 1986;36(5):937–940. doi: 10.1016/0031-9384(86)90456-7. [DOI] [PubMed] [Google Scholar]
  13. Farrell P. A., Gates W. K., Maksud M. G., Morgan W. P. Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans. J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1245–1249. doi: 10.1152/jappl.1982.52.5.1245. [DOI] [PubMed] [Google Scholar]
  14. Folkins C. H. Effects of physical training on mood. J Clin Psychol. 1976 Apr;32(2):385–388. doi: 10.1002/1097-4679(197604)32:2<385::aid-jclp2270320237>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  15. Folkins C. H., Lynch S., Gardner M. M. Psychological fitness as a function of physical fitness. Arch Phys Med Rehabil. 1972 Nov;53(11):503–508. [PubMed] [Google Scholar]
  16. Folkins C. H., Sime W. E. Physical fitness training and mental health. Am Psychol. 1981 Apr;36(4):373–389. doi: 10.1037//0003-066x.36.4.373. [DOI] [PubMed] [Google Scholar]
  17. Fraioli F., Moretti C., Paolucci D., Alicicco E., Crescenzi F., Fortunio G. Physical exercise stimulates marked concomitant release of beta-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man. Experientia. 1980 Aug 15;36(8):987–989. doi: 10.1007/BF01953837. [DOI] [PubMed] [Google Scholar]
  18. Gambert S. R., Garthwaite T. L., Pontzer C. H., Cook E. E., Tristani F. E., Duthie E. H., Martinson D. R., Hagen T. C., McCarty D. J. Running elevates plasma beta-endorphin immunoreactivity and ACTH in untrained human subjects. Proc Soc Exp Biol Med. 1981 Oct;168(1):1–4. doi: 10.3181/00379727-168-41225. [DOI] [PubMed] [Google Scholar]
  19. Gambert S. R., Garthwaite T. L., Tate P. W. Clinical implications of the endogenous opiates: Part I. Physiological. Psychiatr Med. 1983 Jan;1(1):93–105. [PubMed] [Google Scholar]
  20. Gianoulakis C., Gupta A. Inbred strains of mice with variable sensitivity to ethanol exhibit differences in the content and processing of beta-endorphin. Life Sci. 1986 Dec 15;39(24):2315–2325. doi: 10.1016/0024-3205(86)90662-4. [DOI] [PubMed] [Google Scholar]
  21. Gianoulakis C. The effect of ethanol on the biosynthesis and regulation of opioid peptides. Experientia. 1989 May 15;45(5):428–435. doi: 10.1007/BF01952024. [DOI] [PubMed] [Google Scholar]
  22. Gosnell B. A. Central structures involved in opioid-induced feeding. Fed Proc. 1987 Jan;46(1):163–167. [PubMed] [Google Scholar]
  23. Gosnell B. A. Involvement of mu opioid receptors in the amygdala in the control of feeding. Neuropharmacology. 1988 Mar;27(3):319–326. doi: 10.1016/0028-3908(88)90050-0. [DOI] [PubMed] [Google Scholar]
  24. Gosnell B. A., Morley J. E., Levine A. S. Opioid-induced feeding: localization of sensitive brain sites. Brain Res. 1986 Mar 26;369(1-2):177–184. doi: 10.1016/0006-8993(86)90526-3. [DOI] [PubMed] [Google Scholar]
  25. Haier R. J., Quaid K., Mills J. C. Naloxone alters pain perception after jogging. Psychiatry Res. 1981 Oct;5(2):231–232. doi: 10.1016/0165-1781(81)90052-4. [DOI] [PubMed] [Google Scholar]
  26. Hamilton M. G., Blum K., Hirst M. Identification of an isoquinoline alkaloid after chronic exposure to ethanol. Alcohol Clin Exp Res. 1978 Apr;2(2):133–137. doi: 10.1111/j.1530-0277.1978.tb04713.x. [DOI] [PubMed] [Google Scholar]
  27. Hynes M. D., Lochner M. A., Bemis K. G., Hymson D. L. Chronic ethanol alters the receptor binding characteristics of the delta opioid receptor ligand, D-Ala2-D-Leu5 enkephalin in mouse brain. Life Sci. 1983 Dec 5;33(23):2331–2337. doi: 10.1016/0024-3205(83)90267-9. [DOI] [PubMed] [Google Scholar]
  28. Janal M. N., Colt E. W., Clark W. C., Glusman M. Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: effects of naloxone. Pain. 1984 May;19(1):13–25. doi: 10.1016/0304-3959(84)90061-7. [DOI] [PubMed] [Google Scholar]
  29. Jeffcoate W. J., Herbert M., Cullen M. H., Hastings A. G., Walder C. P. Prevention of effects of alcohol intoxication by naloxone. Lancet. 1979 Dec 1;2(8153):1157–1159. doi: 10.1016/s0140-6736(79)92385-7. [DOI] [PubMed] [Google Scholar]
  30. Jefferys D. B., Flanagan R. J., Volans G. N. Reversal of ethanol-induced coma with naloxone. Lancet. 1980 Feb 9;1(8163):308–309. doi: 10.1016/s0140-6736(80)90800-4. [DOI] [PubMed] [Google Scholar]
  31. Jonas J. M., Gold M. S. Naltrexone reverses bulimic symptoms. Lancet. 1986 Apr 5;1(8484):807–807. doi: 10.1016/s0140-6736(86)91822-2. [DOI] [PubMed] [Google Scholar]
  32. Kather H., Simon B. Opioid peptides and obesity. Lancet. 1979 Oct 27;2(8148):905–905. doi: 10.1016/s0140-6736(79)92722-3. [DOI] [PubMed] [Google Scholar]
  33. Katz R. J. Behavioral effects of dynorphin -- a novel opioid neuropeptide. Neuropharmacology. 1980 Aug;19(8):801–803. doi: 10.1016/0028-3908(80)90074-x. [DOI] [PubMed] [Google Scholar]
  34. Kavaliers M., Hirst M. Slugs and snails and opiate tales: opioids and feeding behavior in invertebrates. Fed Proc. 1987 Jan;46(1):168–172. [PubMed] [Google Scholar]
  35. Komisaruk B. R., Wallman J. Antinociceptive effects of vaginal stimulation in rats: neurophysiological and behavioral studies. Brain Res. 1977 Nov 25;137(1):85–107. doi: 10.1016/0006-8993(77)91014-9. [DOI] [PubMed] [Google Scholar]
  36. Langenfeld M. E., Hart L. S., Kao P. C. Plasma beta-endorphin responses to one-hour bicycling and running at 60% VO2max. Med Sci Sports Exerc. 1987 Apr;19(2):83–86. [PubMed] [Google Scholar]
  37. MARGULES D. L., OLDS J. Identical "feeding" and "rewarding" systems in the lateral hypothalamus of rats. Science. 1962 Feb 2;135(3501):374–375. doi: 10.1126/science.135.3501.374. [DOI] [PubMed] [Google Scholar]
  38. Mackenzie A. I. Naloxone in alcohol intoxication. Lancet. 1979 Mar 31;1(8118):733–734. doi: 10.1016/s0140-6736(79)91196-6. [DOI] [PubMed] [Google Scholar]
  39. Markoff R. A., Ryan P., Young T. Endorphins and mood changes in long-distance running. Med Sci Sports Exerc. 1982;14(1):11–15. doi: 10.1249/00005768-198201000-00002. [DOI] [PubMed] [Google Scholar]
  40. McCloy R. F., McCloy J. Autoaddiction: a hypothesis on hunger and obesity. Am Heart J. 1980 Dec;100(6 Pt 1):933–934. doi: 10.1016/0002-8703(80)90079-4. [DOI] [PubMed] [Google Scholar]
  41. Mirin S. M., Meyer R. E., Mendelson J. H., Ellingboe J. Opiate use and sexual function. Am J Psychiatry. 1980 Aug;137(8):909–915. doi: 10.1176/ajp.137.8.909. [DOI] [PubMed] [Google Scholar]
  42. Mitchell J. E., Laine D. E., Morley J. E., Levine A. S. Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome. Biol Psychiatry. 1986 Dec;21(14):1399–1406. doi: 10.1016/0006-3223(86)90331-8. [DOI] [PubMed] [Google Scholar]
  43. Morley J. E. Appetite regulation: the role of peptides and hormones. J Endocrinol Invest. 1989 Feb;12(2):135–147. doi: 10.1007/BF03349944. [DOI] [PubMed] [Google Scholar]
  44. Morley J. E., Levine A. S. Dynorphin-(1-13) induces spontaneous feeding in rats. Life Sci. 1981 Nov 2;29(18):1901–1903. doi: 10.1016/0024-3205(81)90522-1. [DOI] [PubMed] [Google Scholar]
  45. Morley J. E., Levine A. S., Grace M., Kneip J. Dynorphin-(1-13), dopamine and feeding in rats. Pharmacol Biochem Behav. 1982 May;16(5):701–705. doi: 10.1016/0091-3057(82)90221-0. [DOI] [PubMed] [Google Scholar]
  46. Morley J. E., Levine A. S. Stress-induced eating is mediated through endogenous opiates. Science. 1980 Sep 12;209(4462):1259–1261. doi: 10.1126/science.6250222. [DOI] [PubMed] [Google Scholar]
  47. Morley J. E., Levine A. S. The central control of appetite. Lancet. 1983 Feb 19;1(8321):398–401. doi: 10.1016/s0140-6736(83)91511-8. [DOI] [PubMed] [Google Scholar]
  48. Morley J. E. The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor. Life Sci. 1980 Aug 4;27(5):355–368. doi: 10.1016/0024-3205(80)90183-6. [DOI] [PubMed] [Google Scholar]
  49. Myers R. D., Melchior C. L. Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain. Science. 1977 Apr 29;196(4289):554–556. doi: 10.1126/science.557839. [DOI] [PubMed] [Google Scholar]
  50. Naber D., Soble M. G., Pickar D. Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatria. 1981 Sep;14(5):160–161. doi: 10.1055/s-2007-1019590. [DOI] [PubMed] [Google Scholar]
  51. Pert C. B., Snyder S. H. Opiate receptor: demonstration in nervous tissue. Science. 1973 Mar 9;179(4077):1011–1014. doi: 10.1126/science.179.4077.1011. [DOI] [PubMed] [Google Scholar]
  52. Rahkila P., Hakala E., Salminen K., Laatikainen T. Response of plasma endorphins to running exercises in male and female endurance athletes. Med Sci Sports Exerc. 1987 Oct;19(5):451–455. [PubMed] [Google Scholar]
  53. Romsos D. R., Gosnell B. A., Morley J. E., Levine A. S. Effects of kappa opiate agonists, cholecystokinin and bombesin on intake of diets varying in carbohydrate-to-fat ratio in rats. J Nutr. 1987 May;117(5):976–985. doi: 10.1093/jn/117.5.976. [DOI] [PubMed] [Google Scholar]
  54. Schulz R., Wüster M., Duka T., Herz A. Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. Psychopharmacology (Berl) 1980;68(3):221–227. doi: 10.1007/BF00428107. [DOI] [PubMed] [Google Scholar]
  55. Seevers M. H., Davis V. E., Walsh M. J. Morphine and ethanol physical dependence: a critique of a hypothesis. Science. 1970 Dec 4;170(3962):1113–1115. doi: 10.1126/science.170.3962.1113. [DOI] [PubMed] [Google Scholar]
  56. Seizinger B. R., Bovermann K., Maysinger D., Höllt V., Herz A. Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary. Pharmacol Biochem Behav. 1983;18 (Suppl 1):361–369. doi: 10.1016/0091-3057(83)90200-9. [DOI] [PubMed] [Google Scholar]
  57. Sforzo G. A. Opioids and exercise. An update. Sports Med. 1989 Feb;7(2):109–124. doi: 10.2165/00007256-198907020-00003. [DOI] [PubMed] [Google Scholar]
  58. Shyu B. C., Andersson S. A., Thorén P. Endorphin mediated increase in pain threshold induced by long-lasting exercise in rats. Life Sci. 1982 Mar 8;30(10):833–840. doi: 10.1016/0024-3205(82)90597-5. [DOI] [PubMed] [Google Scholar]
  59. Stein L., Belluzzi J. D. Brain endorphins and the sense of well-being: a psychobiological hypothesis. Adv Biochem Psychopharmacol. 1978;18:299–311. [PubMed] [Google Scholar]
  60. Steinberg H., Sykes E. A. Introduction to symposium on endorphins and behavioural processes; review of literature on endorphins and exercise. Pharmacol Biochem Behav. 1985 Nov;23(5):857–862. doi: 10.1016/0091-3057(85)90083-8. [DOI] [PubMed] [Google Scholar]
  61. Szechtman H., Hershkowitz M., Simantov R. Sexual behavior decreases pain sensitivity and stimulated endogenous opioids in male rats. Eur J Pharmacol. 1981 Mar 26;70(3):279–285. doi: 10.1016/0014-2999(81)90161-8. [DOI] [PubMed] [Google Scholar]
  62. Zioudrou C., Streaty R. A., Klee W. A. Opioid peptides derived from food proteins. The exorphins. J Biol Chem. 1979 Apr 10;254(7):2446–2449. [PubMed] [Google Scholar]
  63. de Meirleir K., Naaktgeboren N., Van Steirteghem A., Gorus F., Olbrecht J., Block P. Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise. Eur J Appl Physiol Occup Physiol. 1986;55(1):5–8. doi: 10.1007/BF00422884. [DOI] [PubMed] [Google Scholar]
  64. van Ree J. M., Smyth D. G., Colpaert F. C. Dependence creating properties of lipotropin C-fragment (beta-endorphin): evidence for its internal control of behavior. Life Sci. 1979 Feb 5;24(6):495–502. doi: 10.1016/0024-3205(79)90170-x. [DOI] [PubMed] [Google Scholar]

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