Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1992 Apr;55(4):304–307. doi: 10.1136/jnnp.55.4.304

Levodopa induced ON-OFF motor fluctuations in Parkinson's disease related to rhythmical masticatory jaw movements.

S Karlsson 1, M Persson 1, B Johnels 1
PMCID: PMC489044  PMID: 1316430

Abstract

The motor disturbance in Parkinson's disease affects all voluntary movement, including innate rhythmical processes such as gait, breathing, and chewing. While there are good descriptions and pathophysiological hypotheses of the changes in gait less is known about the way masticatory movements are affected. By means of a three-dimensional optoelectronic recording technique the differences were investigated in mandibular movement displacement, velocity, and masticatory cycle duration during levodopa induced OFF and ON states. Recordings were made before ordinary morning medication and one hour after medication with 200 mg levodopa and a decarboxylase inhibitor (madopar). There were no differences before and after medication in the opening and closing duration of the masticatory cycle, but a significantly decreased occlusal level phase duration in the ON state was seen. Mandibular velocity and mandibular movement amplitude were significantly greater after medication. Thus the changes in dopamine transmission selectively influenced parts of the masticatory cycle but not the fundamental rhythmical pattern.

Full text

PDF
304

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benecke R., Rothwell J. C., Dick J. P., Day B. L., Marsden C. D. Performance of simultaneous movements in patients with Parkinson's disease. Brain. 1986 Aug;109(Pt 4):739–757. doi: 10.1093/brain/109.4.739. [DOI] [PubMed] [Google Scholar]
  2. Benecke R., Rothwell J. C., Dick J. P., Day B. L., Marsden C. D. Simple and complex movements off and on treatment in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):296–303. doi: 10.1136/jnnp.50.3.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caligiuri M. P., Abbs J. H. Response properties of the perioral reflex in Parkinson's disease. Exp Neurol. 1987 Dec;98(3):563–572. doi: 10.1016/0014-4886(87)90265-2. [DOI] [PubMed] [Google Scholar]
  4. Enomoto S., Schwartz G., Lund J. P. The effects of cortical ablation on mastication in the rabbit. Neurosci Lett. 1987 Nov 23;82(2):162–166. doi: 10.1016/0304-3940(87)90122-4. [DOI] [PubMed] [Google Scholar]
  5. Evarts E. V., Teräväinen H., Calne D. B. Reaction time in Parkinson's disease. Brain. 1981 Mar;104(Pt 1):167–186. doi: 10.1093/brain/104.1.167. [DOI] [PubMed] [Google Scholar]
  6. Forssberg H., Johnels B., Steg G. Is parkinsonian gait caused by a regression to an immature walking pattern? Adv Neurol. 1984;40:375–379. [PubMed] [Google Scholar]
  7. Hannam A. G., Matthews B. Reflex jaw opening in response to stimulation of periodontal mechanoreceptors in the cat. Arch Oral Biol. 1969 Apr;14(4):415–419. doi: 10.1016/0003-9969(69)90096-x. [DOI] [PubMed] [Google Scholar]
  8. Johnels B., Ingvarsson P. E., Thorselius M., Valls M., Steg G. Disability profiles and objective quantitative assessment in Parkinson's disease. Acta Neurol Scand. 1989 Mar;79(3):227–238. doi: 10.1111/j.1600-0404.1989.tb03743.x. [DOI] [PubMed] [Google Scholar]
  9. Karlsson S., Carlsson G. E. Characteristics of mandibular masticatory movement in young and elderly dentate subjects. J Dent Res. 1990 Feb;69(2):473–476. doi: 10.1177/00220345900690021101. [DOI] [PubMed] [Google Scholar]
  10. Karlsson S., Carlsson G. E. Recording of masticatory mandibular movements and velocity by an optoelectronic method. Int J Prosthodont. 1989 Sep-Oct;2(5):490–496. [PubMed] [Google Scholar]
  11. Lund J. P., Dellow P. G. Rhythmical masticatory activity of hypoglossal motoneurons responding to an oral stimulus. Exp Neurol. 1973 Jul;40(1):243–246. doi: 10.1016/0014-4886(73)90139-8. [DOI] [PubMed] [Google Scholar]
  12. Lund J. P., Lamarre Y. Activity of neurons in the lower precentral cortex during voluntary and rhythmical jaw movements in the monkey. Exp Brain Res. 1974 Feb 15;19(3):282–299. doi: 10.1007/BF00233235. [DOI] [PubMed] [Google Scholar]
  13. Lund J. P., Sasamoto K., Murakami T., Olsson K. A. Analysis of rhythmical jaw movements produced by electrical stimulation of motor-sensory cortex of rabbits. J Neurophysiol. 1984 Dec;52(6):1014–1029. doi: 10.1152/jn.1984.52.6.1014. [DOI] [PubMed] [Google Scholar]
  14. Nakamura Y., Kubo Y. Masticatory rhythm in intracellular potential of trigeminal motoneurons induced by stimulation of orbital cortex and amygdala in cats. Brain Res. 1978 Jun 16;148(2):504–509. doi: 10.1016/0006-8993(78)90738-2. [DOI] [PubMed] [Google Scholar]
  15. Nishino H., Ono T., Fukuda M., Sasaki K. Monkey substantia nigra (pars reticulata) neuron discharges during operant feeding. Brain Res. 1985 May 13;334(1):190–193. doi: 10.1016/0006-8993(85)90587-6. [DOI] [PubMed] [Google Scholar]
  16. Plesh O., Bishop B., McCall W. Effect of gum hardness on chewing pattern. Exp Neurol. 1986 Jun;92(3):502–512. doi: 10.1016/0014-4886(86)90292-x. [DOI] [PubMed] [Google Scholar]
  17. Sanes J. N., Jennings V. A. Centrally programmed patterns of muscle activity in voluntary motor behavior of humans. Exp Brain Res. 1984;54(1):23–32. doi: 10.1007/BF00235815. [DOI] [PubMed] [Google Scholar]
  18. Schneider J. S., Diamond S. G., Markham C. H. Deficits in orofacial sensorimotor function in Parkinson's disease. Ann Neurol. 1986 Mar;19(3):275–282. doi: 10.1002/ana.410190309. [DOI] [PubMed] [Google Scholar]
  19. Stern Y., Mayeux R., Rosen J., Ilson J. Perceptual motor dysfunction in Parkinson's disease: a deficit in sequential and predictive voluntary movement. J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):145–151. doi: 10.1136/jnnp.46.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES