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. 2016 Feb 7;7(9):10472–10485. doi: 10.18632/oncotarget.7228

Figure 1. Inhibition of the Shh pathway leads to reduced cell motility and invasive potential.

Figure 1

KAT-18 A. and SW1736 B. seeded in uncoated or Matrigel-coated Boyden chambers in duplicate were incubated for 24 hr in the presence of 0.5% DMSO, cyclopamine (5 μM) or GANT61 (10 μM). Cells migrating through the pored PET membrane were stained in Diff-Quik solutions. Data represent the mean ± SD of the numbers of the cells in five random fields (10X) in duplicate. The experiment was repeated at least twice with similar results. *p < 0.05; **p < 0.01.