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. 1992 Jul;55(7):566–571. doi: 10.1136/jnnp.55.7.566

A controlled, longitudinal study of dementia in Parkinson's disease.

C A Biggins 1, J L Boyd 1, F M Harrop 1, P Madeley 1, R H Mindham 1, J I Randall 1, E G Spokes 1
PMCID: PMC489167  PMID: 1640232

Abstract

Serial assessments of cognition, mood, and disability were carried out at nine month intervals over a 54 month period on a cohort of 87 patients with Parkinson's disease (PD) and a matched cohort of 50 control subjects. Dementia was diagnosed from data by rigorously applying DSM-III-R criteria. Initially, 6% (5/87) PD patients were demented, compared with none of the 50 control subjects. A further 10 PD patients met the dementia criteria during the follow up period; this was equivalent, with survival analysis, to a cumulative incidence of 19%. With the number of person years of observation as the denominator, the incidence was 47.6/1000 person years of observation. None of the control subjects fulfilled dementia criteria during the follow up period. The patients with PD who became demented during follow up were older at onset of Parkinson's disease than patients who did not become demented, had a longer duration of Parkinson's disease, and were older at inclusion to the study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyd J. L., Cruickshank C. A., Kenn C. W., Madeley P., Mindham R. H., Oswald A. G., Smith R. J., Spokes E. G. Cognitive impairment and dementia in Parkinson's disease: a controlled study. Psychol Med. 1991 Nov;21(4):911–921. doi: 10.1017/s0033291700029901. [DOI] [PubMed] [Google Scholar]
  2. Brown R. G., Marsden C. D. How common is dementia in Parkinson's disease? Lancet. 1984 Dec 1;2(8414):1262–1265. doi: 10.1016/s0140-6736(84)92807-1. [DOI] [PubMed] [Google Scholar]
  3. Diamond S. G., Markham C. H. Evaluating the evaluations: or how to weigh the scales of parkinsonian disability. Neurology. 1983 Aug;33(8):1098–1099. doi: 10.1212/wnl.33.8.1098. [DOI] [PubMed] [Google Scholar]
  4. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  5. Gibb W. R. Dementia and Parkinson's disease. Br J Psychiatry. 1989 May;154:596–614. doi: 10.1192/bjp.154.5.596. [DOI] [PubMed] [Google Scholar]
  6. Gibb W. R., Lees A. J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745–752. doi: 10.1136/jnnp.51.6.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Girotti F., Soliveri P., Carella F., Piccolo I., Caffarra P., Musicco M., Caraceni T. Dementia and cognitive impairment in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1498–1502. doi: 10.1136/jnnp.51.12.1498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
  9. Lees A. J. Parkinson's disease and dementia. Lancet. 1985 Jan 5;1(8419):43–44. doi: 10.1016/s0140-6736(85)90986-9. [DOI] [PubMed] [Google Scholar]
  10. Lima B., Neves G., Nora M. Juvenile Parkinsonism: clinical and metabolic characteristics. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):345–348. doi: 10.1136/jnnp.50.3.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Martin W. E., Loewenson R. B., Resch J. A., Baker A. B. Parkinson's disease. Clinical analysis of 100 patients. Neurology. 1973 Aug;23(8):783–790. doi: 10.1212/wnl.23.8.783. [DOI] [PubMed] [Google Scholar]
  12. Mayeux R., Chen J., Mirabello E., Marder K., Bell K., Dooneief G., Cote L., Stern Y. An estimate of the incidence of dementia in idiopathic Parkinson's disease. Neurology. 1990 Oct;40(10):1513–1517. doi: 10.1212/wnl.40.10.1513. [DOI] [PubMed] [Google Scholar]
  13. Mayeux R., Stern Y., Rosenstein R., Marder K., Hauser A., Cote L., Fahn S. An estimate of the prevalence of dementia in idiopathic Parkinson's disease. Arch Neurol. 1988 Mar;45(3):260–262. doi: 10.1001/archneur.1988.00520270034017. [DOI] [PubMed] [Google Scholar]
  14. Montgomery S. A., Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979 Apr;134:382–389. doi: 10.1192/bjp.134.4.382. [DOI] [PubMed] [Google Scholar]
  15. Oyebode J. R., Barker W. A., Blessed G., Dick D. J., Britton P. G. Cognitive functioning in Parkinson's disease: in relation to prevalence of dementia and psychiatric diagnosis. Br J Psychiatry. 1986 Dec;149:720–725. doi: 10.1192/bjp.149.6.720. [DOI] [PubMed] [Google Scholar]
  16. Quinn N., Critchley P., Marsden C. D. Young onset Parkinson's disease. Mov Disord. 1987;2(2):73–91. doi: 10.1002/mds.870020201. [DOI] [PubMed] [Google Scholar]
  17. Taylor A., Saint-Cyr J. A., Lang A. E. Dementia prevalence in Parkinson's disease. Lancet. 1985 May 4;1(8436):1037–1037. doi: 10.1016/s0140-6736(85)91631-9. [DOI] [PubMed] [Google Scholar]
  18. Webster D. D. Critical analysis of the disability in Parkinson's disease. Mod Treat. 1968 Mar;5(2):257–282. [PubMed] [Google Scholar]

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