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. 1992 Jul;55(7):572–576. doi: 10.1136/jnnp.55.7.572

A component analysis of the generation and release of isometric force in Parkinson's disease.

N Jordan 1, H J Sagar 1, J A Cooper 1
PMCID: PMC489168  PMID: 1640233

Abstract

Paradigms of isometric force control allow study of the generation and release of movement in the absence of complications due to disordered visuomotor coordination. The onset and release of isometric force in Parkinson's disease (PD) was studied, using computerised determinants of latency of response and rate of force generation and release. Components of isometric force control were related to measures of cognitive, affective and clinical motor disability. The effects of treatment were determined by longitudinal study of de novo patients. Patients with PD showed impairment in latency and rate of force change for movement release as well as onset. Rate of force change correlated with depression, clinical motor disability and memory quotient but latency showed no correlation with any of these measures. Treatment improved rate of force release, in concert with clinical motor disability, but not latency. These results suggest dissociations between latency and rate of force change that may be linked to different neurochemical deficits. Further, they demonstrate akinetic deficits in force release that argue against the "neural energy hypothesis" of akinesia.

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Selected References

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  1. Angel R. W., Alston W., Higgins J. R. Control of movement in Parkinson's disease. Brain. 1970;93(1):1–14. doi: 10.1093/brain/93.1.1. [DOI] [PubMed] [Google Scholar]
  2. Benecke R., Rothwell J. C., Dick J. P., Day B. L., Marsden C. D. Disturbance of sequential movements in patients with Parkinson's disease. Brain. 1987 Apr;110(Pt 2):361–379. doi: 10.1093/brain/110.2.361. [DOI] [PubMed] [Google Scholar]
  3. Benecke R., Rothwell J. C., Dick J. P., Day B. L., Marsden C. D. Performance of simultaneous movements in patients with Parkinson's disease. Brain. 1986 Aug;109(Pt 4):739–757. doi: 10.1093/brain/109.4.739. [DOI] [PubMed] [Google Scholar]
  4. Berardelli A., Dick J. P., Rothwell J. C., Day B. L., Marsden C. D. Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1273–1279. doi: 10.1136/jnnp.49.11.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Blessed G., Tomlinson B. E., Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968 Jul;114(512):797–811. doi: 10.1192/bjp.114.512.797. [DOI] [PubMed] [Google Scholar]
  6. Bloxham C. A., Mindel T. A., Frith C. D. Initiation and execution of predictable and unpredictable movements in Parkinson's disease. Brain. 1984 Jun;107(Pt 2):371–384. doi: 10.1093/brain/107.2.371. [DOI] [PubMed] [Google Scholar]
  7. Brown R. G., Marsden C. D., Quinn N., Wyke M. A. Alterations in cognitive performance and affect-arousal state during fluctuations in motor function in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1984 May;47(5):454–465. doi: 10.1136/jnnp.47.5.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brown R. G., Marsden C. D. Visuospatial function in Parkinson's disease. Brain. 1986 Oct;109(Pt 5):987–1002. doi: 10.1093/brain/109.5.987. [DOI] [PubMed] [Google Scholar]
  9. Hallett M., Khoshbin S. A physiological mechanism of bradykinesia. Brain. 1980 Jun;103(2):301–314. doi: 10.1093/brain/103.2.301. [DOI] [PubMed] [Google Scholar]
  10. Helliwell P., Howe A., Wright V. Functional assessment of the hand: reproducibility, acceptability, and utility of a new system for measuring strength. Ann Rheum Dis. 1987 Mar;46(3):203–208. doi: 10.1136/ard.46.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MILNER B. Psychological defects produced by temporal lobe excision. Res Publ Assoc Res Nerv Ment Dis. 1958;36:244–257. [PubMed] [Google Scholar]
  12. Nelson H. E., O'Connell A. Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test. Cortex. 1978 Jun;14(2):234–244. doi: 10.1016/s0010-9452(78)80049-5. [DOI] [PubMed] [Google Scholar]
  13. Stelmach G. E., Teasdale N., Phillips J., Worringham C. J. Force production characteristics in Parkinson's disease. Exp Brain Res. 1989;76(1):165–172. doi: 10.1007/BF00253633. [DOI] [PubMed] [Google Scholar]
  14. Stelmach G. E., Worringham C. J. The preparation and production of isometric force in Parkinson's disease. Neuropsychologia. 1988;26(1):93–103. doi: 10.1016/0028-3932(88)90033-4. [DOI] [PubMed] [Google Scholar]
  15. Wing A. M. A comparison of the rate of pinch grip force increases and decreases in parkinsonian bradykinesia. Neuropsychologia. 1988;26(3):479–482. doi: 10.1016/0028-3932(88)90100-5. [DOI] [PubMed] [Google Scholar]

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