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. 1992 Jul;55(7):613–615. doi: 10.1136/jnnp.55.7.613

Acute sensory and autonomic neuropathy: possible association with coxsackie B virus infection.

G Pavesi 1, F Gemignani 1, G M Macaluso 1, P Ventrua 1, G Magnani 1, A Fiocchi 1, D Medici 1, A Marbini 1, D Mancia 1
PMCID: PMC489176  PMID: 1322452

Abstract

This report describes a 26 year old woman with a Coxsackie B virus infection complicated by an acute pandysautonomic and sensory neuropathy. Electrophysiological studies suggested an axonal neuropathy. A sural nerve biopsy performed early in the disease showed axonal degeneration with a virtual absence of unmyelinated fibres and moderate loss of myelinated fibres, mainly affecting the small fibres; this differs from previous reports. An immune-mediated or direct virus action might explain the pathogenesis of this unusual evolution of a viral infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appenzeller O., Kornfeld M. Acute pandysautonomia. Clinical and morphologic study. Arch Neurol. 1973 Nov;29(5):334–339. doi: 10.1001/archneur.1973.00490290074010. [DOI] [PubMed] [Google Scholar]
  2. Colan R. V., Snead O. C., 3rd, Oh S. J., Kashlan M. B. Acute autonomic and sensory neuropathy. Ann Neurol. 1980 Oct;8(4):441–444. doi: 10.1002/ana.410080419. [DOI] [PubMed] [Google Scholar]
  3. Ewing D. J. Cardiovascular reflexes and autonomic neuropathy. Clin Sci Mol Med. 1978 Oct;55(4):321–327. doi: 10.1042/cs0550321. [DOI] [PubMed] [Google Scholar]
  4. Fagius J., Westerberg C. E., Olsson Y. Acute pandysautonomia and severe sensory deficit with poor recovery. A clinical, neurophysiological and pathological case study. J Neurol Neurosurg Psychiatry. 1983 Aug;46(8):725–733. doi: 10.1136/jnnp.46.8.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Goulon M., Nouailhat F., Grosbuis S., Gajdos P. Hypotension orthostatique à pouls invariable. Etude hémodynamique d'une neuropathie amyloïde et d'une forme idiopathique transitoire. Rev Neurol (Paris) 1971 Oct;125(4):257–272. [PubMed] [Google Scholar]
  6. Hopkins A., Neville B., Bannister R. Autonomic neuropathy of acute onset. Lancet. 1974 Apr 27;1(7861):769–771. doi: 10.1016/s0140-6736(74)92840-2. [DOI] [PubMed] [Google Scholar]
  7. Low P. A., Dyck P. J., Lambert E. H., Brimijoin W. S., Trautmann J. C., Malagelada J. R., Fealey R. D., Barrett D. M. Acute panautonomic neuropathy. Ann Neurol. 1983 Apr;13(4):412–417. doi: 10.1002/ana.410130407. [DOI] [PubMed] [Google Scholar]
  8. Neville B. G., Sladen G. E. Acute autonomic neuropathy following primary herpes simplex infection. J Neurol Neurosurg Psychiatry. 1984 Jun;47(6):648–650. doi: 10.1136/jnnp.47.6.648. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Okada F., Yamashita I., Suwa N. Two cases of acute pandysautonomia. Arch Neurol. 1975 Mar;32(3):146–151. doi: 10.1001/archneur.1975.00490450026002. [DOI] [PubMed] [Google Scholar]
  10. Taubner R. W., Salanova V. Acute dysautonomia and polyneuropathy. Arch Neurol. 1984 Oct;41(10):1100–1101. doi: 10.1001/archneur.1984.04050210102025. [DOI] [PubMed] [Google Scholar]
  11. Wichman A., Buchthal F., Pezeshkpour G. H., Fauci A. S. Peripheral neuropathy in hypereosinophilic syndrome. Neurology. 1985 Aug;35(8):1140–1145. doi: 10.1212/wnl.35.8.1140. [DOI] [PubMed] [Google Scholar]
  12. Wichser J., Vijayan N., Dreyfus P. M. Dysautonomia--its significance in neurologic disease. Calif Med. 1972 Oct;117(4):28–37. [PMC free article] [PubMed] [Google Scholar]
  13. Yahr M. D., Frontera A. T. Acute autonomic neuropathy. Its occurrence in infectious mononucleosis. Arch Neurol. 1975 Feb;32(2):132–133. doi: 10.1001/archneur.1975.00490440082014. [DOI] [PubMed] [Google Scholar]
  14. Young R. R., Asbury A. K., Adams R. D., Corbett J. L. Pure pan-dysautonomia with recovery. Trans Am Neurol Assoc. 1969;94:355–357. [PubMed] [Google Scholar]
  15. Young R. R., Asbury A. K., Corbett J. L., Adams R. D. Pure pan-dysautonomia with recovery. Description and discussion of diagnostic criteria. Brain. 1975 Dec;98(4):613–636. doi: 10.1093/brain/98.4.613. [DOI] [PubMed] [Google Scholar]

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