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Frontiers in Pharmacology logoLink to Frontiers in Pharmacology
. 2016 Jun 6;7:165. doi: 10.3389/fphar.2016.00165

Erratum: Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach

Frontiers Production Office1,*
PMCID: PMC4894375  PMID: 27375487

Reason for Erratum:

Due to a typesetting error, the article was published with incorrect values in Table 4. The publisher apologizes for this error and the correct version of Table 4 appears below. This error does not change the scientific conclusions of the article in any way.

Table 4.

MM-PBSA results compared to experimental binding parameters.

Complex Binding parameters MM-PBSA energy terms (KJ/mol)
Kon/105 (M−1 s−1) Koff/10−5 (s−1) KD (pM) ΔEbinding ΔEVdW ΔEelectrostatic ΔGPolar ΔGApolar
Ranibizumab/VEGFA 1.60 0.73 46 −760 ± 40 −418 ± 5 −160 ± 20 410 ± 30 −592 ± 7
Fab-bevacizumab/VEGFA 5.30 3.10 58 −807 ± 30 −362 ± 10 −252 ± 20 343 ± 30 −536 ± 7
VEGFR1d2_R2d3/VEGFA 410 2.01 0.49 −1440 ± 90 −307 ± 50 −1433 ± 100 1050 ± 100 −750 ± 40

Kinetic and binding parameters are from Papadopoulos et al. (2012).

References

  1. Papadopoulos N., Martin J., Ruan Q., Rafique A., Rosconi M. P., Shi E., et al. (2012). Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 15, 171–185. 10.1007/s10456-011-9249-6 [DOI] [PMC free article] [PubMed] [Google Scholar]

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