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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: Biochemistry. 2015 Mar 5;54(10):1863–1878. doi: 10.1021/acs.biochem.5b00025

Figure 3.

Figure 3

Structure and mechanism of cytochrome c oxidase proteins. (a) Structure of CcO from bovine (PDB ID 2EIJ20) where the H+ loading pathways are labeled and the black bar indicates the approximate width of a lipid bilayer; (b) Close-up view of the redox cofactors in the active site; and (c) Mechanism of reduction of O2, including commonly used one-letter abbreviations for the intermediate species. The red colored spheres indicated reduced metal sites and the green spheres indicate oxidized sites.