Avery PR, Burton J, Bromberek JL, Seelig DM, Elmslie R, Correa S, Ehrhart EJ, Morley PS, Avery AC. Flow Cytometric Characterization and Clinical Outcome of CD4+ T‐Cell Lymphoma in Dogs: 67 Cases. J Vet Intern Med 2014; 28: 538–546.
Article first published online: 3 FEB 2014 | DOI: 10.1111/jvim.12304
Table 2: There was a misidentification of the reference variable for cell size. The p value for PFI difference for Multi‐agent tx should be 0.0039 as stated in the text, not the 0.0091 listed in the table. The revised Table 2 is below.
Table 2.
Summary of PFI and survival analysis for selected clinical and immunophenotypic characteristics.
| Variable (# of patients)* | Univariable Analysis | Multivariable Analysis | ||||
|---|---|---|---|---|---|---|
| PFI | P‐value for PFI difference | Overall survival (range) | P‐value for survival difference | Hazard ratio for PFI | Hazard ratio for survival | |
| CD5 expression | ||||||
| Positive (34) | 77 (65 ‐ 111) | 0.1353 | 143 (92 ‐ 159) | 0.0056 | — | 2.5 (1.2 ‐ 5.1) |
| Negative (26)** | 98 (65 ‐ 175) | 195 (137 ‐ 314) | 1 | |||
| Cell size | ||||||
| Small (30) | 121 (73 ‐ 191) | 0.0012 | 206 (146 ‐ 235) | 0.0146 | 1 | 1 |
| Large (31) | 77 (44 ‐ 91) | 130 (91 ‐ 159) | 3.3 (1.6 ‐ 6.6) | 2.2 (1.1 ‐ 4.3) | ||
| Multi‐agent tx | ||||||
| MOPP (10) | 131 (35 ‐ 266) | 0.0039 | 114 (35 ‐ 194) | 0.0001 | 1.6 (0.6 ‐ 4.1) | 2.0 (0.7 ‐ 5.3) |
| Single Agent (22) | 70 (43 ‐ 81) | 170 (104 ‐ 218) | 3.1 (1.5 ‐ 6.3) | 1.6 (0.7 ‐ 3.5) | ||
| Prednisone (11) | — | 80 (8 ‐ 130) | — | 2.7 (1.1 ‐ 6.7) | ||
| CHOP (18) | 109 (91 ‐ 191) | 237 (159 ‐ 312) | 1 | 1 | ||
| Calcium status | ||||||
| High (28) | 83 (65 ‐ 182) | 0.5532 | 141 (95 ‐ 185) | 0.1323 | — | — |
| Normal (22) | 113 (73 ‐ 167) | 170 (137 ‐ 272) | ||||
| Mediastinal Mass | ||||||
| Present (15) | 81 (28 ‐ 113) | 0.0801 | 130 (40 ‐ 195) | 0.1762 | — | — |
| Absent (18) | 140 (65 ‐ 191) | 155 (91 ‐ 435) | ||||
| Substage | ||||||
| b (13) | 97 (48 ‐ 204) | 0.7495 | 106 (20 ‐ 195) | 0.0085 | — | 4.1 (1.7 ‐ 9.9) |
| a (48) | 91 (69 ‐ 111) | 164 (137 ‐ 210) | 1 | |||
Numbers reflect the number of dogs analyzed for overall survival. Fewer animals were analyzed for PFI since the prednisone treated patients were not included in this group. Only patients with CD45+ T cell lymphoma are included in this table.
Not all values were available for all dogs. For example in one dog, CD5 staining was not performed so there are only 60 dogs in the CD5 outcome analysis.
Fig 3 legend: There was a difference between 2 parameters in PFI as stated in the text and reflected in Table 2.
Figure 3.
Progression‐free interval (PFI) is significantly different for single‐agent chemotherapy compared with CHOP. Overall survival is significantly different for prednisone only compared to CHOP. Only dogs with CD4+/CD45+ lymphoma were included in this analysis.