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. 1993 Sep;56(9):982–987. doi: 10.1136/jnnp.56.9.982

Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome.

D Adams 1, T Kuntzer 1, A J Steck 1, A Lobrinus 1, R C Janzer 1, F Regli 1
PMCID: PMC489733  PMID: 8410039

Abstract

A patient with a progressive lower motor neuron syndrome and neurophysiological evidence of motor axon loss, multifocal proximal motor nerve conduction block, and high titres of anti-ganglioside GM1 antibodies. Neuropathological findings included a predominantly proximal motor radiculoneuropathy with multifocal IgG and IgM deposits on nerve fibres associated with a loss of spinal motor neurons. These findings support an autoimmune origin of this lower motor neuron syndrome with retrograde degeneration of spinal motor neurons and severe neurogenic muscular atrophy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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