Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1993 Sep;56(9):1008–1012. doi: 10.1136/jnnp.56.9.1008

A clinico-pathological study of adult histiocytosis X involving the brain.

K Hasegawa 1, T Mitomi 1, H Kowa 1, T Motoori 1, S Yagisita 1
PMCID: PMC489739  PMID: 8410024

Abstract

Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.

Full text

PDF
1008

Images in this article

1009Image
on p.1009
1009Image
on p.1009
1010Image
on p.1010
1010Image
on p.1010
1010Image
on p.1010

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Rodhan N. R., Al-Mefty O., Godwin J. T., Jinkins J. R., Fox J. L. Histiocytosis-X of the spinal cord: a case report. Neurosurgery. 1986 Nov;19(5):837–840. doi: 10.1227/00006123-198611000-00023. [DOI] [PubMed] [Google Scholar]
  2. Camilleri M., Krausz T., Lewis P. D., Hodgson H. J., Pallis C. A., Chadwick V. S. Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. Gut. 1983 May;24(5):441–447. doi: 10.1136/gut.24.5.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cerdá-Nicolas M., Broseta J., Peydrò-Olaya A., Barberá J., Barcia-Salorio J. L., Llombart-Bosch A. Primary eosinophilic granuloma of the frontal lobe. Virchows Arch A Pathol Anat Histol. 1980;388(2):221–228. doi: 10.1007/BF00430690. [DOI] [PubMed] [Google Scholar]
  4. Drolshagen L. F., Kessler R., Partain C. L. Cervical meningeal histiocytosis demonstrated by magnetic resonance imaging. Pediatr Radiol. 1987;17(1):63–64. doi: 10.1007/BF02386598. [DOI] [PubMed] [Google Scholar]
  5. Elian M., Bornstein B., Matz S., Askenasy H. M., Sandbank U., Tiqua P. Neurological manifestations of general xanthomatosis. Hand-Schuller-Christian disease. Arch Neurol. 1969 Aug;21(2):115–120. doi: 10.1001/archneur.1969.00480140015001. [DOI] [PubMed] [Google Scholar]
  6. FEIGIN I. Xanthomatosis of the nervous system. J Neuropathol Exp Neurol. 1956 Oct;15(4):400–416. doi: 10.1097/00005072-195610000-00004. [DOI] [PubMed] [Google Scholar]
  7. Geoffray A. Case of the season. Diagnosis: histiocytosis X of the central nervous system. Semin Roentgenol. 1984 Oct;19(4):257–258. doi: 10.1016/0037-198x(84)90003-8. [DOI] [PubMed] [Google Scholar]
  8. Greenwood S. M., Martin J. S., Towfighi J. Unifocal eosinophilic granuloma of the temporal lobe. Surg Neurol. 1982 Jun;17(6):441–444. doi: 10.1016/s0090-3019(82)80015-3. [DOI] [PubMed] [Google Scholar]
  9. Hewlett R. H., Ganz J. C. Histiocytosis X of the cauda equina. Neurology. 1976 May;26(5):472–476. doi: 10.1212/wnl.26.5.472. [DOI] [PubMed] [Google Scholar]
  10. Hirai S., Morimatsu M., Fukuchi Y., Yoshikawa M., Yamaguchi K. [Autopsy case of Hand-Schüller-Christian disease with intracerebral lipogranuloma]. Rinsho Shinkeigaku. 1972 Feb;12(2):87–94. [PubMed] [Google Scholar]
  11. Kepes J. J., Kepes M., Slowik F. Fibrous xanthomas and xanthosarcomas of the meninges and the brain. Acta Neuropathol. 1973 Feb 19;23(3):187–199. doi: 10.1007/BF00687875. [DOI] [PubMed] [Google Scholar]
  12. LICHTENSTEIN L. Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol. 1953 Jul;56(1):84–102. [PubMed] [Google Scholar]
  13. Rubé J., De la Pava S., Pickren J. W. Histiocytosis X with involvement of brain. Cancer. 1967 Apr;20(4):486–492. doi: 10.1002/1097-0142(1967)20:4<486::aid-cncr2820200405>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  14. Salcman M., Quest D. O., Mount L. A. Histiocytosis-x of the spinal cord. Case report. J Neurosurg. 1974 Sep;41(3):383–386. doi: 10.3171/jns.1974.41.3.0383. [DOI] [PubMed] [Google Scholar]
  15. Sivalingam S., Corkill G., Ellis W. G., Claiche J. R. Focal eosinophilic granuloma of the temporal lobe. Case report. J Neurosurg. 1977 Dec;47(6):941–945. doi: 10.3171/jns.1977.47.6.0941. [DOI] [PubMed] [Google Scholar]
  16. Waldron R. L., 2nd, Paysinger B. D., Reynolds J. C., Jordan A. E. Histiocytosis-X: extra-hypothalamic involvement of the central nervous system. Br J Radiol. 1984 May;57(677):435–438. doi: 10.1259/0007-1285-57-677-435. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES