Figure 5.

Social novelty may be slightly affected by phase and genotype. A, Time spent in the chamber shows that there was a near significant interaction a phase × genotype × chamber. A post hoc pairwise analysis showed a significant difference between the times spent in the chamber with the familiar mouse in the active phase for control (n=27 active phase) (n=22 inactive phase) and Fmr1 KO (n=33 active phase) (n=21 inactive phase) mice. There was also a near significant preference in the time spent in the chamber with the novel mouse compared with the familiar mouse in the Fmr1 KO mice during the active phase only. B, Both control and Fmr1 KO mice showed a preference for social novelty based on the time spent sniffing the novel mouse compared with the familiar mouse. This did not differ by genotype or phase. ^∗ (p<0.05); ∼ (0.05<p<0.10). Each bar represents the mean +/− SEM for the number of mice indicated in parentheses.