Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1979 Jan;42(1):78–81. doi: 10.1136/jnnp.42.1.78

Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.

K Kmieciak-Kolada, H Majchrzak, Z S Herman
PMCID: PMC490163  PMID: 216782

Abstract

In 12 patients with different posterior fossa tumours the concentrations of homovanillic acid (HVA) and of 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid from the lateral ventricles. All patients had obstructive hydrocephalus. Patients with a clear increase of 5-HIAA/HVA ratio in the ventricular CSF have died subsequently. This feature may have a diagnostic value, and indicates the prevalence of serotoninergic neurones in patients with obstructive hydrocephalus with fatal course after surgery.

Full text

PDF
78

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDEN N. E., ROOS B. E., WERDINIUS B. On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method. Life Sci. 1963 Jul;(7):448–458. doi: 10.1016/0024-3205(63)90132-2. [DOI] [PubMed] [Google Scholar]
  2. Andersson H., Roos B. E. Increased level of 5-hydroxyindoleacetic acid in cerebrospinal fluid from infantile hydrocephalus. Experientia. 1966 Aug 15;22(8):539–540. doi: 10.1007/BF01898679. [DOI] [PubMed] [Google Scholar]
  3. Chase T. N., Gordon E. K., Ng L. K. Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid. J Neurochem. 1973 Sep;21(3):581–587. doi: 10.1111/j.1471-4159.1973.tb06003.x. [DOI] [PubMed] [Google Scholar]
  4. Edvinsson L., Owman C., Rosengren E., West K. A. Brain concentrations of dopamine, noradrenaline, 5-hydroxytryptamine, and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit. Acta Neurol Scand. 1971;47(4):458–463. doi: 10.1111/j.1600-0404.1971.tb07500.x. [DOI] [PubMed] [Google Scholar]
  5. Garelis E., Young S. N., Lal S., Sourkes T. L. Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Res. 1974 Oct 11;79(1):1–8. doi: 10.1016/0006-8993(74)90562-9. [DOI] [PubMed] [Google Scholar]
  6. Gerbode F. A., Bowers M. B. Measurement of acid monoamine metabolites in human and animal cerebrospinal fluid. J Neurochem. 1968 Sep;15(9):1053–1055. doi: 10.1111/j.1471-4159.1968.tb11648.x. [DOI] [PubMed] [Google Scholar]
  7. Maira G., Bareggi S. R., Di Rocco C., Calderini G., Morselli P. L. Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results. J Neurol Neurosurg Psychiatry. 1975 Feb;38(2):123–128. doi: 10.1136/jnnp.38.2.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Miller F. P., Cox R. H., Jr, Snodgrass W. R., Maickel R. P. Comparative effects of p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem Pharmacol. 1970 Feb;19(2):435–442. doi: 10.1016/0006-2952(70)90199-1. [DOI] [PubMed] [Google Scholar]
  9. Moir A. T., Ashcroft G. W., Crawford T. B., Eccleston D., Guldberg H. C. Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain. Brain. 1970;93(2):357–368. doi: 10.1093/brain/93.2.357. [DOI] [PubMed] [Google Scholar]
  10. Osterholm J. L., Bell J., Meyer R., Pyenson J. Experimental effects of free serotonin on the brain and its relation to brain injury. 1. The neurological consequences of intracerebral serotonin injections. 2. Trauma-induced alterations in spinal fluid and brain. 3. Serotonin-induced cerebral edema. J Neurosurg. 1969 Oct;31(4):408–412. doi: 10.3171/jns.1969.31.4.0408. [DOI] [PubMed] [Google Scholar]
  11. Porta M., Bareggi S. R., Collice M., Assael B. M., Selenati A., Calderini G., Rossanda M., Morselli P. L. Homovanillic acid and 5-hydroxyindole-acetic acid in the csf of patients after a severe head injury. II. Ventricular csf concentrations in acute brain post-traumatic syndromes. Eur Neurol. 1975;13(6):545–554. doi: 10.1159/000114710. [DOI] [PubMed] [Google Scholar]
  12. Sjöström R., Ekstedt J., Anggård E. Concentration gradients of monoamine metabolites in human cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1975 Jul;38(7):666–668. doi: 10.1136/jnnp.38.7.666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wilk S., Stanley M. Dopamine metabolites in human brain. Psychopharmacology (Berl) 1978 Apr 14;57(1):77–81. doi: 10.1007/BF00426961. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES