Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1979 Jan;42(1):82–88. doi: 10.1136/jnnp.42.1.82

Influence of site of origin of lung carcinomas on clinical presentation and central nervous system metastases.

B E Tomlinson, R H Perry, E G Stewart-Wynne
PMCID: PMC490164  PMID: 216783

Abstract

A retrospective survey of 100 patients dying from carcinoma of the lung showed that neurological presentation and central nervous system metastases are more frequently present when the primary carcinoma is situated in the peripheral lung tissue (including lung apex). The high incidence of cases presenting neurologically and the high incidence of single secondary deposits involving the central nervous system from peripheral or apical growths suggest a difference in the mode of spread or other properties of such growths compared with the more common central carcinoma.

Full text

PDF
82

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON R. Diodrast studies of the vertebral and cranial venous systems to show their probable role in cerebral metastases. J Neurosurg. 1951 Jul;8(4):411–422. doi: 10.3171/jns.1951.8.4.0411. [DOI] [PubMed] [Google Scholar]
  2. BAKAY L. Results of surgical treatment of intracranial metastasis from pulmonary cancer; report of a case with five-year survival. J Neurosurg. 1958 May;15(3):338–341. doi: 10.3171/jns.1958.15.3.0338. [DOI] [PubMed] [Google Scholar]
  3. GALLUZZI S., PAYNE P. M. Brain metastases from primary bronchial carcinoma: a statistical study of 741 necropsies. Br J Cancer. 1956 Sep;10(3):408–414. doi: 10.1038/bjc.1956.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hazra T., Mullins G. M., Lott S. Management of cerebral metastasis from bronchogenic carcinoma. Johns Hopkins Med J. 1972 Jun;130(6):377–383. [PubMed] [Google Scholar]
  5. MEYER P. C., REAH T. G. Secondary neoplasms of the central nervous system and meninges. Br J Cancer. 1953 Dec;7(4):438–448. doi: 10.1038/bjc.1953.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Modesti L. M., Feldman R. A. Solitary cerebral metastasis from pulmonary cancer. Prolonged survival after surgery. JAMA. 1975 Mar 10;231(10):1064–1064. [PubMed] [Google Scholar]
  7. Newman S. J., Hansen H. H. Proceedings: Frequency, diagnosis, and treatment of brain metastases in 247 consecutive patients with bronchogenic carcinoma. Cancer. 1974 Feb;33(2):492–496. doi: 10.1002/1097-0142(197402)33:2<492::aid-cncr2820330225>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  8. ONUIGBO W. I. Some observations on the spread of lung cancer in the body. Br J Cancer. 1957 Jun;11(2):175–180. doi: 10.1038/bjc.1957.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pedersen H. E., Hjelms E., Struve-Christensen E., Dyrbye M. Intracranial metastasis from cancer of the lung. A prospective study of the diagnostic validity of positive and negative findings in neurological examination, electroencephalography, 99m Tc brain scanning, and lumbar puncture before thoracotomy. J Thorac Cardiovasc Surg. 1973 Jan;65(1):159–164. [PubMed] [Google Scholar]
  10. WACK J. P., DUBUQUE T., WYATT J. P. The role of the vertebral venous plexus in the dissemination of labeled emboli. AMA Arch Pathol. 1958 Jun;65(6):675–680. [PubMed] [Google Scholar]
  11. WATANABE S. The metastasizability of tumor cells. Cancer. 1954 Mar;7(2):215–223. doi: 10.1002/1097-0142(195403)7:2<215::aid-cncr2820070203>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  12. Weiss W., Boucot K. R., Cooper D. A. The histopathology of bronchogenic carcinoma and its relation to growth rate, metastasis, and prognosis. Cancer. 1970 Nov;26(5):965–970. doi: 10.1002/1097-0142(197011)26:5<965::aid-cncr2820260502>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES