Abstract
Eleven patients with sustained neuralgia, in most cases after traumatic nerve lesion, were subjected to quantitative sensory testing with thermal and non-noxious mechanical stimuli. Measurements were made in the pain area and at a homologous site on the contralateral normal side. All patients were hypoaesthetic with raised thresholds for warm and cold or touch, or both. Thermal pain thresholds were also raised in some patients but lowered in others indicating hypersensitivity of the nociceptor system or dysaesthesia for thermal input. In six patients single mechanical stimuli produced a painful response above the touch detection threshold. Reaction time measurements indicated that this painful response to suprathreshold mechanical pulses was measured by magnitude estimation as a function of stimulus amplitude. The results were fitted by power functions, as in normal skin, but with steeper slopes on the abnormal side. Suprathreshold hyperaesthesia (recruitment) may exist in the presence of normal threshold functioning.
Full text
PDF













Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albe-Fessard D., Fessard A. Recent advances on the neurophysiological bases of pain sensation. Acta Neurobiol Exp (Wars) 1975;35(5-6):715–740. [PubMed] [Google Scholar]
- Anderson L. S., Black R. G., Abraham J., Ward A. A., Jr Neuronal hyperactivity in experimental trigeminal deafferentation. J Neurosurg. 1971 Oct;35(4):444–452. doi: 10.3171/jns.1971.35.4.0444. [DOI] [PubMed] [Google Scholar]
- Burgess P. R., Horch K. W. Specific regeneration of cutaneous fibers in the cat. J Neurophysiol. 1973 Jan;36(1):101–114. doi: 10.1152/jn.1973.36.1.101. [DOI] [PubMed] [Google Scholar]
- Denny-Brown D., Kirk E. J., Yanagisawa N. The tract of Lissauer in relation to sensory transmission in the dorsal horn of spinal cord in the macaque monkey. J Comp Neurol. 1973 Sep 15;151(2):175–200. doi: 10.1002/cne.901510206. [DOI] [PubMed] [Google Scholar]
- Fruhstorfer H., Lindblom U., Schmidt W. C. Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1071–1075. doi: 10.1136/jnnp.39.11.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindblom U., Meyerson B. A. Influence on touch, vibration and cutaneous pain of dorsal column stimulation in man. Pain. 1975 Sep;1(3):257–270. doi: 10.1016/0304-3959(75)90042-1. [DOI] [PubMed] [Google Scholar]
- Lindblom U. Touch perception threshold in human glabrous skin in terms of displacement amplitude on stimulation with single mechanical pulses. Brain Res. 1974 Dec 27;82(2):205–210. doi: 10.1016/0006-8993(74)90599-x. [DOI] [PubMed] [Google Scholar]
- Melzack R. Phantom limb pain: implications for treatment of pathologic pain. Anesthesiology. 1971 Oct;35(4):409–419. [PubMed] [Google Scholar]
- Melzack R., Wall P. D. Pain mechanisms: a new theory. Science. 1965 Nov 19;150(3699):971–979. doi: 10.1126/science.150.3699.971. [DOI] [PubMed] [Google Scholar]
- Richards R. L. Causalgia. A centennial review. Arch Neurol. 1967 Apr;16(4):339–350. doi: 10.1001/archneur.1967.00470220003001. [DOI] [PubMed] [Google Scholar]
- STEVENS S. S. Tactile vibration: dynamics of sensory intensity. J Exp Psychol. 1959 Apr;57(4):210–218. doi: 10.1037/h0042828. [DOI] [PubMed] [Google Scholar]
- STEVENS S. S. The direct estimation of sensory magnitudes-loudness. Am J Psychol. 1956 Mar;69(1):1–25. [PubMed] [Google Scholar]
- Shibasaki H., Kuroiwa Y. Painful tonic seizure in multiple sclerosis. Arch Neurol. 1974 Jan;30(1):47–51. doi: 10.1001/archneur.1974.00490310049008. [DOI] [PubMed] [Google Scholar]
- Trotter W., Davies H. M. Experimental studies in the innervation of the skin. J Physiol. 1909 Feb 9;38(2-3):134–246.1. doi: 10.1113/jphysiol.1909.sp001299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Verrillo R. T., Ecker A. D. Effects of root or nerve destruction on vibrotactile sensitivity in trigeminal neuralgia. Pain. 1977 Jun;3(3):239–255. doi: 10.1016/0304-3959(77)90005-7. [DOI] [PubMed] [Google Scholar]
- Wall P. D., Gutnick M. Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma. Exp Neurol. 1974 Jun;43(3):580–593. doi: 10.1016/0014-4886(74)90197-6. [DOI] [PubMed] [Google Scholar]