Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1979 May;42(5):452–457. doi: 10.1136/jnnp.42.5.452

Nervous system complications of herpes zoster: immunofluorescent demonstration of varicella-zoster antigen in CSF cells

A C B Peters 1,2,3,4, J Versteeg 1,2,3,4, G TH A M Bots 1,2,3,4, J Lindeman 1,2,3,4, R E H Smeets 1,2,3,4
PMCID: PMC490232  PMID: 221620

Abstract

In nine out of 11 patients with herpes zoster and neurological symptoms varicella-zoster antigen was demonstrated in CSF cells by indirect immunofluorescent staining. Cerebrospinal fluid cytology was in most cases highly suggestive of viral infection. This study demonstrates the value of both immunofluorescent staining on CSF cells and CSF cytology, as corroboration of an otherwise exclusively serologically based virological diagnosis.

Full text

PDF
452

Images in this article

456Image
on p.456
456Image
on p.456

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APPELBAUM E., KREPS S. I., SUNSHINE A. Herpes zoster encephalitis. Am J Med. 1962 Jan;32:25–31. doi: 10.1016/0002-9343(62)90179-1. [DOI] [PubMed] [Google Scholar]
  2. Bastian F. O., Rabson A. S., Yee C. L., Tralka T. S. Herpesvirus varicellae isolated from human dorsal root ganglia. Arch Pathol. 1974 May;97(5):331–333. [PubMed] [Google Scholar]
  3. Berlin B. S., Campbell T. Hospital-acquired herpes zoster following exposure to chickenpox. JAMA. 1970 Mar 16;211(11):1831–1833. [PubMed] [Google Scholar]
  4. Dayan A. D., Stokes M. I. Rapid diagnosis of encephalitis by immunofluorescent examination of cerebrospinal-fluid cells. Lancet. 1973 Jan 27;1(7796):177–179. doi: 10.1016/s0140-6736(73)90006-8. [DOI] [PubMed] [Google Scholar]
  5. Djupesland G., Berdal P., Johannessen T. A., Degré M., Stien R., Skrede S. Viral infection as a cause of acute peripheral facial palsy. Arch Otolaryngol. 1976 Jul;102(7):403–406. doi: 10.1001/archotol.1976.00780120051005. [DOI] [PubMed] [Google Scholar]
  6. Feldman S., Epp E. Isolation of varicellazoster virus from blood. J Pediatr. 1976 Feb;88(2):265–267. doi: 10.1016/s0022-3476(76)80995-x. [DOI] [PubMed] [Google Scholar]
  7. Feldman S., Hughes W. T., Kim H. Y. Herpes zoster in children with cancer. Am J Dis Child. 1973 Aug;126(2):178–184. doi: 10.1001/archpedi.1973.02110190156009. [DOI] [PubMed] [Google Scholar]
  8. Gardner-Thorpe C., Foster J. B., Barwick D. D. Unusual manifestations of herpes zoster. A clinical and electrophysiological study. J Neurol Sci. 1976 Aug;28(4):427–447. doi: 10.1016/0022-510x(76)90115-5. [DOI] [PubMed] [Google Scholar]
  9. Gold E. Serologic and virus-isolation studies of patients with varicella or herpes-zoster infection. N Engl J Med. 1966 Jan 27;274(4):181–185. doi: 10.1056/NEJM196601272740403. [DOI] [PubMed] [Google Scholar]
  10. Grumbach K., Baringer J. R., Klassen T. Herpes-simplex antigen in rabbit cerebrospinal fluid. Lancet. 1977 Jan 15;1(8003):149–149. doi: 10.1016/s0140-6736(77)91749-4. [DOI] [PubMed] [Google Scholar]
  11. HOPE-SIMPSON R. E. THE NATURE OF HERPES ZOSTER: A LONG-TERM STUDY AND A NEW HYPOTHESIS. Proc R Soc Med. 1965 Jan;58:9–20. doi: 10.1177/003591576505800106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hotson J. R., Pedley T. A. The neurological complications of cardiac transplantation. Brain. 1976 Dec;99(4):673–694. doi: 10.1093/brain/99.4.673. [DOI] [PubMed] [Google Scholar]
  13. Jarratt M., Hubler W. R., Jr Herpes genitalis and aseptic meningitis. Arch Dermatol. 1974 Nov;110(5):771–772. [PubMed] [Google Scholar]
  14. Joncas J., Lussier G., Podoski M. O., Rona S. Zoster encephalitis: a case report. Can J Public Health. 1968 Dec;59(12):484–486. [PubMed] [Google Scholar]
  15. Levin M. J., Zaia J. A. Immunosuppression and infection-progress. N Engl J Med. 1977 Jun 16;296(24):1406–1408. doi: 10.1056/NEJM197706162962411. [DOI] [PubMed] [Google Scholar]
  16. Lindeman J., Müller W. K., Versteeg J., Bots G. T., Peters A. C. Rapid diagnosis of meningoencephalitis, encephalitis. Immunofluorescent examination of fresh and in vitro cultured cerebrospinal fluid cells. Neurology. 1974 Feb;24(2):143–148. doi: 10.1212/wnl.24.2.143. [DOI] [PubMed] [Google Scholar]
  17. Longson M., Liversedge L. A., Wilkinson I. M. Diagnosis of virus encephalitis. Lancet. 1973 Feb 17;1(7799):371–371. doi: 10.1016/s0140-6736(73)90158-x. [DOI] [PubMed] [Google Scholar]
  18. Marshall W. J. Herpes simplex encephalitis treated with idoxuridine and external decompression. Lancet. 1967 Sep 16;2(7516):579–580. doi: 10.1016/s0140-6736(67)90736-2. [DOI] [PubMed] [Google Scholar]
  19. Olding-Stenkvist E. Acute necrotizing herpes simplex virus encephalitis--diagnostic problems. Scand J Infect Dis. 1974;6(4):355–360. doi: 10.3109/inf.1974.6.issue-4.11. [DOI] [PubMed] [Google Scholar]
  20. Peters A. C., Versteeg J., Lindeman J., Bots G. T. Viral meningoencephalitis and head injury. Acta Neurol Scand. 1978 Jan;57(1):77–87. doi: 10.1111/j.1600-0404.1978.tb04499.x. [DOI] [PubMed] [Google Scholar]
  21. Plotkin S. A., Stein S., Snyder M., Immesoete P. Attempts to recover varicella virus from ganglia. Ann Neurol. 1977 Sep;2(3):249–249. doi: 10.1002/ana.410020313. [DOI] [PubMed] [Google Scholar]
  22. Shibuta H., Ishikawa T., Hondo R., Aoyama Y., Kurata K., Matumoto M. Varicella virus isolation from spinal ganglion. Arch Gesamte Virusforsch. 1974;45(4):382–385. doi: 10.1007/BF01242884. [DOI] [PubMed] [Google Scholar]
  23. Shoji H., Koya M., Ogiwara H. Meningitis associated with herpes zoster. Immunofluorescent demonstration of varicella-zoster antigens in CSF cells. J Neurol. 1976;213(3):269–271. doi: 10.1007/BF00312877. [DOI] [PubMed] [Google Scholar]
  24. TAYLOR-ROBINSON D., DOWNIE A. W. Chickenpox and herpes zoster. 1. Complement fixation studies. Br J Exp Pathol. 1959 Aug;40:398–409. [PMC free article] [PubMed] [Google Scholar]
  25. Taber L. H., Brasier F., Couch R. B., Greenberg S. B., Jones D., Knight V. Diagnosis of herpes simplex virus infection by immunofluorescence. J Clin Microbiol. 1976 Mar;3(3):309–312. doi: 10.1128/jcm.3.3.309-312.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Taber L. H., Mirkovic R. R., Adam V., Ellis S. S., Yow M. D., Melnick J. L. Rapid diagnosis of enterovirus meningitis by immunofluorescent staining of CSF leukocytes. Intervirology. 1973;1(2):127–134. doi: 10.1159/000148839. [DOI] [PubMed] [Google Scholar]
  27. Tomlinson A. H., MacCallum F. O. Virus antigen in cells of lumbar cerebrospinal fluid. Lancet. 1973 Feb 10;1(7798):319–320. doi: 10.1016/s0140-6736(73)91565-1. [DOI] [PubMed] [Google Scholar]
  28. WELLER T. H., COONS A. H. Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789–794. doi: 10.3181/00379727-86-21235. [DOI] [PubMed] [Google Scholar]
  29. WELLER T. H. Serial propagation in vitro of agents producing inclusion bodies derived from varicella and herpes zoster. Proc Soc Exp Biol Med. 1953 Jun;83(2):340–346. doi: 10.3181/00379727-83-20354. [DOI] [PubMed] [Google Scholar]
  30. WELLER T. H., WITTON H. M., BELL E. J. The etiologic agents of varicella and herpes zoster; isolation, propagation, and cultural characteristics in vitro. J Exp Med. 1958 Dec 1;108(6):843–868. doi: 10.1084/jem.108.6.843. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES