Abstract
Fifteen patients with symptomatic cluster headache participated in a double-blind crossover trial of a combined histamine H1 and H2 antagonist treatment. The trial lasted six weeks. There was no significant improvement on active treatment as regards mean number of headache attacks per week, intensity, or duration of attacks. These results suggest that histamine does not play a significant role in the pathogenesis of cluster headache.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anthony M., Lance J. W. Histamine and serotonin in cluster headache. Arch Neurol. 1971 Sep;25(3):225–231. doi: 10.1001/archneur.1971.00490030051005. [DOI] [PubMed] [Google Scholar]
- Lord G. D., Mylecharane E. J., Duckworth J. W., Lance J. W. Histamine2--receptor blockade with cimetidine in the monkey cranial circulation. Proc Aust Assoc Neurol. 1976;13:135–142. [PubMed] [Google Scholar]
- Sjaastad O., Sjaastad O. V. The histaminuria in vascular headache. Acta Neurol Scand. 1970;46(3):331–342. doi: 10.1111/j.1600-0404.1970.tb05797.x. [DOI] [PubMed] [Google Scholar]