Abstract
The concentrations of homovanillic acid (HVA), 3-methoxy, 4-hydroxyphenylglycol (MHPG), and 5-hydroxyindolylacetic acid (5-HIAA) were measured in samples of ventricular cerebrospinal fluid (CSF) taken from 15 patients who were comatose as a result of an acute head injury, a tumour, or a cerebrovascular accident. The metabolite levels were not related to the ventricular fluid pressure. In the eight patients who recovered and from whom serial samples of CSF were obtained, the metabolite levels did not change, except for two patients in whom HVA increased as coma progressed. The concentration of MHPG, but not of HVA or 5-HIAA, was greater (P less than 0.02) in the five patients who died without regaining consciousness than in the 10 patients who recovered.
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- Chase T. N., Gordon E. K., Ng L. K. Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid. J Neurochem. 1973 Sep;21(3):581–587. doi: 10.1111/j.1471-4159.1973.tb06003.x. [DOI] [PubMed] [Google Scholar]
- Davidson D., Pullar I. A., Mawdsley C., Kinloch N., Yates C. M. Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1977 Aug;40(8):741–745. doi: 10.1136/jnnp.40.8.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fyrö B., Wode-Helgodt B., Borg S., Sedvall G. The effect of chlorpromazine on homovanillic acid levels in cerebrospinal fluid of schizophrenic patients. Psychopharmacologia. 1974 Mar 9;35(4):287–294. doi: 10.1007/BF00429219. [DOI] [PubMed] [Google Scholar]
- Gordon E. K., Oliver J. 3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid. Clin Chim Acta. 1971 Nov;35(1):145–150. doi: 10.1016/0009-8981(71)90305-6. [DOI] [PubMed] [Google Scholar]
- Guldberg H. C., Ashcroft G. W., Crawford T. B. Concentrations of 5-hydroxyindolylacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid. Life Sci. 1966 Sep;5(17):1571–1575. doi: 10.1016/0024-3205(66)91026-5. [DOI] [PubMed] [Google Scholar]
- Guldberg H. C., Yates C. M. Effects of chlorpromazine on the metabolism of catecholamines in dog brain. Br J Pharmacol. 1969 Jul;36(3):535–548. doi: 10.1111/j.1476-5381.1969.tb08009.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jouvet M. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergeb Physiol. 1972;64:166–307. doi: 10.1007/3-540-05462-6_2. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Porta M., Bareggi S. R., Collice M., Assael B. M., Selenati A., Calderini G., Rossanda M., Morselli P. L. Homovanillic acid and 5-hydroxyindole-acetic acid in the csf of patients after a severe head injury. II. Ventricular csf concentrations in acute brain post-traumatic syndromes. Eur Neurol. 1975;13(6):545–554. doi: 10.1159/000114710. [DOI] [PubMed] [Google Scholar]
- Tsementzis S. A. Significance of the ventricular fluid pressure wave form in the diagnosis of cerebral circulatory arrest and brain death. Acta Neurochir (Wien) 1978;40(3-4):191–202. doi: 10.1007/BF01774746. [DOI] [PubMed] [Google Scholar]
- Wolfson L. I., Escriva A. Clearance of 3-methoxy-4-hydroxyphenylglycol from the cerebrospinal fluid. Neurology. 1976 Aug;26(8):781–784. doi: 10.1212/wnl.26.8.781. [DOI] [PubMed] [Google Scholar]