Abstract
Patterns of pertechnetate uptake were correlated with ultrastructural properties of the endothelial wall in 14 human brain tumours. In tumours with reduced uptake of the radionuclide, intercellular tight junctions were observed whereas absence of intercellular tight junctions was characteristic of all tumours with an increased uptake of pertechnetate. In some tumours with increased uptake, fenestrated endothelial wall was seen while in others non-fenestrated wall was evident. We concluded that intercellular junctions and not fenestrations affect the permeability of brain tumours to pertechnetate.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brightman M. W., Klatzo I., Olsson Y., Reese T. S. The blood-brain barrier to proteins under normal and pathological conditions. J Neurol Sci. 1970 Mar;10(3):215–239. doi: 10.1016/0022-510x(70)90151-6. [DOI] [PubMed] [Google Scholar]
- Front D. Scintigraphic assessment of vascularity and blood-tissue barrier of human brain tumours. J Neurol Neurosurg Psychiatry. 1978 Jan;41(1):18–23. doi: 10.1136/jnnp.41.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirano A., Zimmerman H. M. Fenestrated blood vessels in a metastatic renal carcinoma in the brain. Lab Invest. 1972 Apr;26(4):465–468. [PubMed] [Google Scholar]
- Long D. M. Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg. 1970 Feb;32(2):127–144. doi: 10.3171/jns.1970.32.2.0127. [DOI] [PubMed] [Google Scholar]
- Long D. M. Vascular ultrastructure in human meningiomas and schwannomas. J Neurosurg. 1973 Apr;38(4):409–419. doi: 10.3171/jns.1973.38.4.0409. [DOI] [PubMed] [Google Scholar]
- Reese T. S., Karnovsky M. J. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol. 1967 Jul;34(1):207–217. doi: 10.1083/jcb.34.1.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vick N. A., Khandekar J. D., Bigner D. D. Chemotherapy of brain tumors. Arch Neurol. 1977 Sep;34(9):523–526. doi: 10.1001/archneur.1977.00500210025002. [DOI] [PubMed] [Google Scholar]