LMI-08: INFANT BRAIN TUMORS IN SINGLE TERTIARY CARE INSTITUTE (SRINAGARIND HOSPITAL, KHON KAEN UNIVERSITY)

Brain tumor in children less than 3 years is infrequently common but devastating outcome and consequence. In order to improve the outcome, the study is to describe the types of brain tumors and outcome of treatment in children during 8-years-period. The descriptive retrospective study is recruited 47 children (Male:Female = 21:26) with mean age 17 months(range from 7 days to 35 months). The types of brain tumor are divided into malignant tumors; medulloblastoma (10), atypical rhabdoid teratoid tumor(5) other rare tumors; pinealoblastoma, ependymoblastoma, CNS lymphoma and primitive neuroectodermal tumors, low grade glioma; pilocystic, pilomyxoid and diffuse astrocytomas, ependymomas (simple in 1 and anaplastic in 3) and other tumors including congenital choroid plexus papilloma and carcinoma and hemangioma. 46 children had tumor removal(from partial to total) and ventriculoperitoneal shunt done according to the types of tumor, only hemangioma case received interferon therapy. Chemotherapy is subsequent treatment followed by radiotherapy according to the tumor. The outcome of death was occurred in 23 children with medulloblastoma, ATRT, anaplastic ependymomas, pinealoblastomas, and ependymoblastomas. The long-term complications among 23 survive children include panhypopituitarism, blindness and neurocognitive impairment. One child is lost to follow-up. In order to improve the outcomes and less complication, the multidisciplinary care team is necessary for early detection of tumor and complications related to tumor, and proper treatment for tumors and complications related to treatment.