QOS-38: ENDOCRINE SEQUELAE AMONG CHILDREN WITH CENTRAL NERVOUS SYSTEM TUMORS AFTER MULTIMODAL ONCOLOGY TREATMENT

BACKGROUND: Endocrine disorders are the most common sequelae after multimodal oncology treatment among children with CNS tumors. METHODS: Establishing the incidence of endocrine sequelae among patients that were followed up at our endocrinology department after the end of multimodal oncology treatment. RESULTS: There were 14 patients (8 girls and 6 boys), median age at the time of diagnosis was 6.75 years (ranged from 1.1 to 16 years). The median follow-up time was 2.8 years (ranged from 5 months to 10.6 years). The primary tumor site was infratentorial in 5 patients and supratentorial in 9 patients. Radiotherapy and chemiotherapy were performed in 6 patients, 2 patients had only chemiotherapy and 6 patients had only radiotherapy. All patients had surgery. Endocrine sequelae were diagnosed in 10 of 14 patients (71,4%). Central hypothyreoidism was diagnosed in 9 patients, 8 had ACTH deficiency, 6 had diabetes insipidus, 3 had GH deficiency and 1 had LH/FSH deficiency. All patients with supratentorial tumor and 1 of 5 patients with infratentorial tumor had endocrine sequelae. Between groups with and without endocrine sequalae there was no statistically significant difference in the age at the time of diagnosis, follow-up time, time from the end of radiotherapy and intensity of treatment. There is statistically significantly higher incidence of endocrine sequalae in children with supratentorial tumor compared with children with infratentorial tumor. CONCLUSION: Central hypothyreoidism is the most common endocrine sequala in our group of children. Further investigations should be performed in order to maximize survival outcome and minimize treatment sequelae.