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. 1979 Nov;42(11):988–994. doi: 10.1136/jnnp.42.11.988

Stiff man syndrome in a black girl.

H Isaacs
PMCID: PMC490391  PMID: 501375

Abstract

A patient suffering from severe and continuous muscular spasms is presented. The condition has been classified as the stiff man syndrome and is the first case recorded of the condition in a young African girl. The electrophysiological, biochemical, histochemical, and ultramicroscopic aspects of this disorder have been studied. The spasm appears to be related to overproduction of brain noradrenaline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHER R. A woman with the stiff-man syndrome. Br Med J. 1958 Feb 1;1(5065):265–266. doi: 10.1136/bmj.1.5065.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chalmers J. P., Baldessarini R. J., Wurtman R. J. Effects of L-dopa on norepinephrine metabolism in the brain. Proc Natl Acad Sci U S A. 1971 Mar;68(3):662–666. doi: 10.1073/pnas.68.3.662. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cohen L. Stiff-man syndrome. Two patients treated with diazepam. JAMA. 1966 Jan 17;195(3):222–224. doi: 10.1001/jama.195.3.222. [DOI] [PubMed] [Google Scholar]
  4. Dekirmenjian H., Maas J. W. An improved procedure of 3-methoxy-4-hydroxyphenyl-ethylene glycol determination by gas-liquid chromatography. Anal Biochem. 1970 May;35(1):113–122. doi: 10.1016/0003-2697(70)90016-3. [DOI] [PubMed] [Google Scholar]
  5. Dziedzic S. W., Bertani L. M., Clarke D. D., Gitlow S. E. A new derivative for the gas-liquid chromatographic determination of homovanillic acid. Anal Biochem. 1972 Jun;47(2):592–600. doi: 10.1016/0003-2697(72)90153-4. [DOI] [PubMed] [Google Scholar]
  6. GELFAN S., TARLOV I. M. ALTERED NEURON POPULATION IN L7 SEGMENT OF DOGS WITH EXPERIMENTAL HIND-LIMB RIGIDITY. Am J Physiol. 1963 Sep;205:606–616. doi: 10.1152/ajplegacy.1963.205.3.606. [DOI] [PubMed] [Google Scholar]
  7. GELFAN S., TARLOV I. M. Interneurones and rigidity of spinal origin. J Physiol. 1959 Jun 11;146(3):594–617. doi: 10.1113/jphysiol.1959.sp006214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOWARD F. M., Jr A new and effective drug in the treatment of the stiff-man syndrome: preliminary report. Proc Staff Meet Mayo Clin. 1963 May 22;38:203–212. [PubMed] [Google Scholar]
  9. LUFT R., IKKOS D., PALMIERI G., ERNSTER L., AFZELIUS B. A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. J Clin Invest. 1962 Sep;41:1776–1804. doi: 10.1172/JCI104637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MOERSCH F. P., WOLTMAN H. W. Progressive fluctuating muscular rigidity and spasm ("stiff-man" syndrome); report of a case and some observations in 13 other cases. Proc Staff Meet Mayo Clin. 1956 Jul 25;31(15):421–427. [PubMed] [Google Scholar]
  11. Martinelli P., Pazzaglia P., Montagna P., Coccagna G., Rizzuto N., Simonati S., Lugaresi E. Stiff-man syndrome associated with nocturnal myoclonus and epilepsy. J Neurol Neurosurg Psychiatry. 1978 May;41(5):458–462. doi: 10.1136/jnnp.41.5.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. OLAFSON R. A., MULDER D. W., HOWARD F. M. "STIFF-MAN" SYNDROME: A REVIEW OF THE LITERATURE, REPORT OF THREE ADDITIONAL CASES AND DISCUSSION OF PATHOPHYSIOLOGY AND THERAPY. Mayo Clin Proc. 1964 Feb;39:131–144. [PubMed] [Google Scholar]
  13. Satoyoshi E. A syndrome of progressive muscle spasm, alopecia, and diarrhea. Neurology. 1978 May;28(5):458–471. doi: 10.1212/wnl.28.5.458. [DOI] [PubMed] [Google Scholar]
  14. Schmidt R. T., Stahl S. M., Spehlmann R. A pharmacologic study of the stiff-man syndrome. Correlation of clinical symptoms with urinary 3-methoxy-4-hydroxy-phenyl glycol excretion. Neurology. 1975 Jul;25(7):622–626. doi: 10.1212/wnl.25.7.622. [DOI] [PubMed] [Google Scholar]
  15. Stern P., Hadzović S. Effect of glycine on experimental hind-limb rigidity in rats. Life Sci I. 1970 Aug 15;9(16):955–959. doi: 10.1016/0024-3205(70)90081-0. [DOI] [PubMed] [Google Scholar]
  16. Stoica E., Enulescu O. Abnormal epinephrine urinary excretion in Parkinsonians: correction of the disorder by levodopa administration. J Neurol Sci. 1978 Sep;38(2):215–227. doi: 10.1016/0022-510x(78)90068-0. [DOI] [PubMed] [Google Scholar]
  17. TANIGUCHI K., KAKIMOTO Y., ARMSTRONG M. D. QUANTITATIVE DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE. J Lab Clin Med. 1964 Sep;64:469–484. [PubMed] [Google Scholar]
  18. TRETHOWAN W. H., ALLSOP J. L., TURNER B. The "stiff-man" syndrome. A report of two further cases. Arch Neurol. 1960 Oct;3:448–456. doi: 10.1001/archneur.1960.00450040098012. [DOI] [PubMed] [Google Scholar]

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