Abstract
Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature. In five of these cases the episode began after an unusually large dose, in three after a therapeutic one with a latency of about 24 hours. The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently. In one patient after three tablets of Mexase a clioquinol concentration of 12 microgram/ml in plasma was found 24 hours after the specified dose, which is an unexpectedly high concentration compared to those reported as late as 24 hours after a single equal dose of Mexase or any other clioquinol-containing preparation. Another patient had a brief relapse two years after the first episode, after a single therapeutic dose of another clioquinol preparation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Degen P. H., Brechbühler S., Schäublin J., Riess W. The determination of phanquone in biological material by gas-liquid chromatography. J Chromatogr. 1976 Apr 7;118(3):363–370. doi: 10.1016/s0021-9673(00)82174-3. [DOI] [PubMed] [Google Scholar]
- Degen P. H., Schneider W., Vuillard P., Geiger U. P., Riess W. The determination of clioquinol in biological materials by extractive alkylation and gas-liquid chromatography. J Chromatogr. 1976 Feb 18;117(2):407–413. doi: 10.1016/0021-9673(76)80018-0. [DOI] [PubMed] [Google Scholar]
- Grondalen T. Osteochondrosis and arthrosis in pigs. I. Incidence in animals up to 120 kg live weight. Acta Vet Scand. 1974;15(1):1–25. doi: 10.1186/BF03547490. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaeser H. E., Scollo-Lavizzari G. Akute zerebrale Störungen nach hohen Doen eines Oxychinolinderivates. Dtsch Med Wochenschr. 1970 Feb 20;95(8):394–397. doi: 10.1055/s-0028-1108472. [DOI] [PubMed] [Google Scholar]
- Kaeser H. E., Wüthrich R. Zur Frage der Neurotoxizität der Oxychinoline. Dtsch Med Wochenschr. 1970 Aug 14;95(33):1685–1688. doi: 10.1055/s-0028-1108711. [DOI] [PubMed] [Google Scholar]
- Kjaersgaard K. Amnesia after clioquinol. Lancet. 1971 Nov 13;2(7733):1086–1086. doi: 10.1016/s0140-6736(71)90397-7. [DOI] [PubMed] [Google Scholar]
- Mumenthaler M. Iatrogne Schäden am Nervensystem und an der Muskulatur Einführung und Ergänzung. Ther Umsch. 1970 Jun;27(6):347–355. [PubMed] [Google Scholar]
- Mumenthaler M., von Roll L. Amnestische Episoden. Schweiz Med Wochenschr. 1969 Feb 1;99(5):133–139. [PubMed] [Google Scholar]
- Püschner H., Fankhauser R. Neuropathologische Befunde bei experimenteller Vioform-Vergiftung der weissen Maus. Schweiz Arch Tierheilkd. 1969 Jul;111(7):371–379. [PubMed] [Google Scholar]
- ROESCH E., ROESCH A., HOFFTER D. POLYNEUROPATHIE DURCH 5-NITRO-8-HYDROXYCHINOLIN IN TIEREXPERIMENTEN. Arch Toxikol. 1965 Feb 10;20:313–322. [PubMed] [Google Scholar]
- SCHMIDT I. G., SCHMIDT L. H. Neurotoxicity of the 8-aminoquinolines. III. The effects of pentaquine, isopentaquine, primaquine, and pamaquine on the central nervous system of the rhesus monkey. J Neuropathol Exp Neurol. 1951 Jul;10(3):231–256. doi: 10.1097/00005072-195107000-00001. [DOI] [PubMed] [Google Scholar]
- Selby G. Subacute myelo-optic neuropathy in Australia. Lancet. 1972 Jan 15;1(7742):123–125. doi: 10.1016/s0140-6736(72)90682-4. [DOI] [PubMed] [Google Scholar]
- Sobue I., Ando K., Iida M., Takayanagi T., Yamamura Y., Matsuoka Y. Myeloneuropathy with abdominal disorders in Japan. A clinical study of 752 cases. Neurology. 1971 Feb;21(2):168–173. doi: 10.1212/wnl.21.2.168. [DOI] [PubMed] [Google Scholar]