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. 2016 Feb 5;7(10):11463–11477. doi: 10.18632/oncotarget.7201

Figure 5. RKIP inhibits activity of ERK-1/2 and AKT signaling in the irradiated NPC cells and xenograft tumors.

Figure 5

(A) (left) a representative result of Western blotting shows the levels of phospho-ERK−1/2, phospho-AKT and RKIP in the RKIP KD CNE2 cells, RKIP OE CNE2-IR cells and their corresponding EV-transfected cells after 4Gy irradiation; (right) a histogram shows the levels of phospho-ERK−1/2, phospho-AKT and RKIP in these cells. (B) (top) a representative result of Western blotting shows the levels of phospho-ERK−1/2, phospho-AKT and RKIP in the tumors generated by RKIP KD CNE2 cells, RKIP OE CNE2-IR cells and their corresponding EV-transfected cells after 8Gy irradiation; (bottom) a histogram shows the expression levels of phospho-ERK-1/2, phosphor-AKT and RKIP in the xenograft tumors. Means, SDs, and statistical significance are denoted; *P < 0.01. OE, overexpression; KD, knockdown; EV, empty vector.