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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1980 May;43(5):397–402. doi: 10.1136/jnnp.43.5.397

Anti-acetylcholine receptor antibody titres in the sera of myasthenia patients treated with plasma exchange combined with immunosuppressive therapy.

B Carter, R Harrison, G G Lunt, P O Behan, J A Simpson
PMCID: PMC490565  PMID: 7420089

Abstract

Anti-acetylcholine receptor antibody titres have been monitored in the sera of 19 myasthenic patients treated with plasma exchange combined with a three month period of immunosuppressive therapy. In general the post-exchange titres stabilised at below pre-exchange levels for prolonged periods which were associated with clinical improvement. In seven instances recurrence of symptoms occurred and in six of these cases relapse was shown to be associated with a rise in anti-acetylcholine receptor antibody titre.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Behan P. O., Shakir R. A., Simpson J. A., Burnett A. K., Allan T. L., Haase G. Plasma-exchange combined with immunosuppressive therapy in myasthenia gravis. Lancet. 1979 Sep 1;2(8140):438–440. doi: 10.1016/s0140-6736(79)91492-2. [DOI] [PubMed] [Google Scholar]
  2. Dau P. C., Lindstrom J. M., Cassel C. K., Denys E. H., Shev E. E., Spitler L. E. Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis. N Engl J Med. 1977 Nov 24;297(21):1134–1140. doi: 10.1056/NEJM197711242972102. [DOI] [PubMed] [Google Scholar]
  3. Finn R., Coates P. M. Plasma exchange in myasthenia gravis. Lancet. 1977 Jan 22;1(8004):190–191. doi: 10.1016/s0140-6736(77)91782-2. [DOI] [PubMed] [Google Scholar]
  4. Lefvert A. K., Bergström K., Matell G., Osterman P. O., Pirskanen R. Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenetic implications. J Neurol Neurosurg Psychiatry. 1978 May;41(5):394–403. doi: 10.1136/jnnp.41.5.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lindstrom J. M., Seybold M. E., Lennon V. A., Whittingham S., Duane D. D. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology. 1976 Nov;26(11):1054–1059. doi: 10.1212/wnl.26.11.1054. [DOI] [PubMed] [Google Scholar]
  6. Lockwood C. M., Rees A. J., Pearson T. A., Evans D. J., Peters D. K., Wilson C. B. Immunosuppression and plasma-exchange in the treatment of Goodpasture's syndrome. Lancet. 1976 Apr 3;1(7962):711–715. doi: 10.1016/s0140-6736(76)93089-0. [DOI] [PubMed] [Google Scholar]
  7. Marengo T. S., Harrison R., Lunt G. G., Behan P. O. Rat or human acetylcholine-receptor antigen for investigation of myasthenia gravis? Lancet. 1979 Feb 24;1(8113):442–442. doi: 10.1016/s0140-6736(79)90919-x. [DOI] [PubMed] [Google Scholar]
  8. McPhaul J. J., Jr, Dixon F. J. Characterization of immunoglobulin G anti-glomerular basement membrane antibodies eluted from kidneys of patients with glomerulonephritis. II. IgG subtypes and in vitro complement fixation. J Immunol. 1971 Sep;107(3):678–684. [PubMed] [Google Scholar]
  9. Mittag T. W., Tormay A., Massa T. Heterogeneity of acetylcholine receptors in denervated muscle: interactions of receptors with immunoglobulin from patients with myasthenia gravis. Mol Pharmacol. 1978 Jan;14(1):60–68. [PubMed] [Google Scholar]
  10. Newsom-Davis J., Pinching A. J., Vincent A., Wilson S. G. Function of circulating antibody to acetylcholine receptor in myasthenia gravis: investigation by plasma exchange. Neurology. 1978 Mar;28(3):266–272. doi: 10.1212/wnl.28.3.266. [DOI] [PubMed] [Google Scholar]
  11. Newsom-Davis J., Wilson S. G., Vincent A., Ward C. D. Long-term effects of repeated plasma exchange in myasthenia gravis. Lancet. 1979 Mar 3;1(8114):464–468. doi: 10.1016/s0140-6736(79)90823-7. [DOI] [PubMed] [Google Scholar]
  12. Pinching A. J., Peters D. K. Remission of myasthenia gravis following plasma-exchange. Lancet. 1976 Dec 25;2(8000):1373–1376. doi: 10.1016/s0140-6736(76)91917-6. [DOI] [PubMed] [Google Scholar]
  13. Simpson J. A. Myasthenia gravis: a personal view of pathogenesis and mechanism, part 2. Muscle Nerve. 1978 Mar-Apr;1(2):151–156. doi: 10.1002/mus.880010208. [DOI] [PubMed] [Google Scholar]
  14. Vincent A., Newsom-Davis J. alpha-Bungarotoxin and anti-acetylcholine receptor antibody binding to the human acetylcholine receptor. Adv Cytopharmacol. 1979;3:269–278. [PubMed] [Google Scholar]
  15. Weinberg C. B., Hall Z. W. Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors. Proc Natl Acad Sci U S A. 1979 Jan;76(1):504–508. doi: 10.1073/pnas.76.1.504. [DOI] [PMC free article] [PubMed] [Google Scholar]

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