Abstract
Central nervous system disorders are not uncommon in patients with hyperparathyroidism and hypercalcaemia. Usually these consist of neuropsychiatric disturbances but acute encephalopathies and seizures may occur. A rare manifestation is cerebral infarction. A patient is presented with neuroradiological evidence of infarction caused by cerebral arterial spasm which appears related to hypercalcaemia due to hypervitaminosis D. Arterial spasm is suggested as a possible aetiological factor in focal neurological lesions associated with hypercalcaemia.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allen G. S., Gross C. J., Henderson L. M., Chou S. N. Cerebral arterial spasm. Part 4: in vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. J Neurosurg. 1976 May;44(5):585–593. doi: 10.3171/jns.1976.44.5.0585. [DOI] [PubMed] [Google Scholar]
- Allen G. S., Henderson L. M., Chou S. N., French L. A. Cerebral arterial spasm. 1. In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg. 1974 Apr;40(4):433–441. doi: 10.3171/jns.1974.40.4.0433. [DOI] [PubMed] [Google Scholar]
- Andersson L., Lindholm T. Less common manifestations of hyperparathyroidism. Acta Med Scand. 1967 Oct;182(4):411–418. doi: 10.1111/j.0954-6820.1967.tb10864.x. [DOI] [PubMed] [Google Scholar]
- BARTTER F. C. The parathyroid gland and its relationship to diseases of the nervous system. Res Publ Assoc Res Nerv Ment Dis. 1953;32:1–20. [PubMed] [Google Scholar]
- BEARE J. M., MILLAR J. H. D. Epileptiform fits during calciferol therapy. Lancet. 1951 Apr 21;1(6660):884–886. [PubMed] [Google Scholar]
- Bauermeister D. E., Jennings E. R., Cruse D. R., Sedgwick V. D. Hypercalcemia with seizures--a clinical paradox. JAMA. 1967 Jul 10;201(2):132–133. [PubMed] [Google Scholar]
- Bohr D. F. Vascular smooth muscle updated. Circ Res. 1973 Jun;32(6):665–672. doi: 10.1161/01.res.32.6.665. [DOI] [PubMed] [Google Scholar]
- Boström H., Alveryd A. Stroke in hyperparathyroidism. Acta Med Scand. 1972 Oct;192(4):299–308. doi: 10.1111/j.0954-6820.1972.tb04819.x. [DOI] [PubMed] [Google Scholar]
- EDWARDS G. A., DAUM S. M. Increased spinal fluid protein in hyperparathyroidism and other hypercalcemic states. AMA Arch Intern Med. 1959 Jul;104(1):29–36. doi: 10.1001/archinte.1959.00270070031004. [DOI] [PubMed] [Google Scholar]
- Edvinsson L., Brandt L., Andersson K. E., Bengtsson B. Effect of a calcium antagonist on experimental constriction of human brain vessels. Surg Neurol. 1979 May;11(5):327–330. [PubMed] [Google Scholar]
- FENTZ V. Hypertensive encephalopathy in a child. Acta Neurol Scand. 1962;38:307–312. doi: 10.1111/j.1600-0404.1962.tb01105.x. [DOI] [PubMed] [Google Scholar]
- FITZ T. E., HALLMAN B. L. Mental changes associated with hyperparathyroidism; report of two cases. AMA Arch Intern Med. 1952 Apr;89(4):547–551. doi: 10.1001/archinte.1952.00240040026003. [DOI] [PubMed] [Google Scholar]
- GELLHORN A., PLIMPTON C. H. Hypercalcemia in malignant disease without evidence of bone destruction. Am J Med. 1956 Nov;21(5):750–759. [PubMed] [Google Scholar]
- HARMON M. Parathyroid adenoma in a child; report of a case presenting as central nervous system disease and complicated by magnesium deficiency. AMA J Dis Child. 1956 Apr;91(4):313–325. doi: 10.1001/archpedi.1956.02060020315001. [DOI] [PubMed] [Google Scholar]
- Herishanu Y., Abramsky O., Lavy S. Focal neurological manifestations in hypercalcemia. Eur Neurol. 1970;4(5):283–288. doi: 10.1159/000114029. [DOI] [PubMed] [Google Scholar]
- KARPATI G., FRAME B. NEUROPSYCHIATRIC DISORDERS IN PRIMARY HYPERPARATHYROIDISM. CLINICAL ANALYSIS WITH REVIEW OF THE LITERATURE. Arch Neurol. 1964 Apr;10:387–397. doi: 10.1001/archneur.1964.00460160057005. [DOI] [PubMed] [Google Scholar]
- LEHRER G. M., LEVITT M. F. Neuropsychiatric presentation of hypercalcemia. J Mt Sinai Hosp N Y. 1960 Jan-Feb;27:10–18. [PubMed] [Google Scholar]
- Moure J. M. The electroencephalogram in hypercalcemia. Arch Neurol. 1967 Jul;17(1):34–51. doi: 10.1001/archneur.1967.00470250038004. [DOI] [PubMed] [Google Scholar]
- ROOKUS P., SPEELMAN J. J. Psychic disturbances in hyperparathyroidism. Psychiatr Neurol Neurochir. 1961 Jan-Feb;64:46–55. [PubMed] [Google Scholar]
- Somlyo A. P., Somlyo A. V. Vascular smooth muscle. I. Normal structure, pathology, biochemistry, and biophysics. Pharmacol Rev. 1968 Dec;20(4):197–272. [PubMed] [Google Scholar]