Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1980 Sep;43(9):810–817. doi: 10.1136/jnnp.43.9.810

Melanotic mucin-producing neuroepithelial neoplasm of mesencephalon with consideration of similar tumours in different locations.

S Shuangshoti
PMCID: PMC490672  PMID: 6999130

Abstract

A six month old boy had a mesencephalic melanotic neoplasm of the neuro-epithelial derivatives which produced mucin. Location in the mesencephalon and production of the mucin have not been described previously for this kind of intracranial tumour. The various cellular elements within the growth are in accord with diverse differentiations of the neuroepithelium of the neural tube, the neuroectodermal part of the neural crest, or both. Derivatives of the neural tube and crest can be melanotic, and some neuroepithelial derivatives (ependyma, oligodendrocyte, and choroidal epithelium) produce mucin. Hence, melanotic neuroepithelial neoplasms with mucinous product can occur. The present tumour is similar to lesions variously designated as melanotic medulloblastoma, retinal anlage tumour, and progonoma. Diverse differentiation of the neuroepithelium of the neural tube, or of the neuroectodermal part of the neural crest, or both would create these variously named tumours. The frequency of melanotic neuroepithelial neoplasms in infancy, and the presence of papillae strongly suggest congental derivation.

Full text

PDF
810

Images in this article

811Image
on p.811
812Image
on p.812
812Image
on p.812

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barden H. The histochemical relationship of neuromelanin and lipofuscin. J Neuropathol Exp Neurol. 1969 Jul;28(3):419–441. doi: 10.1097/00005072-196907000-00005. [DOI] [PubMed] [Google Scholar]
  2. Beatty R. A. Malignant melanoma of the choroid plexus epithelium. Case report. J Neurosurg. 1972 Mar;36(3):344–347. doi: 10.3171/jns.1972.36.3.0344. [DOI] [PubMed] [Google Scholar]
  3. Bird C. C., Willis R. A. The histogenesis of pigmented neurofibromas. J Pathol. 1969 Apr;97(4):631–637. doi: 10.1002/path.1710970407. [DOI] [PubMed] [Google Scholar]
  4. Borello E. D., Gorlin R. J. Melanotic neuroectodermal tumor of infancy--a neoplasm of neural crese origin. Report of a case associated with high urinary excretion of vanilmandelic acid. Cancer. 1966 Feb;19(2):196–206. doi: 10.1002/1097-0142(196602)19:2<196::aid-cncr2820190210>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  5. CLARKE B. E., PARSONS H. An embryological tumor of retinal anlage involving the skull. Cancer. 1951 Jan;4(1):78–85. doi: 10.1002/1097-0142(195101)4:1<78::aid-cncr2820040107>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  6. Caplan R. H., Virata R. L. Functional black adenoma of the adrenal cortex. A rare cause of primary aldosteronism. Am J Clin Pathol. 1974 Jul;62(1):97–103. doi: 10.1093/ajcp/62.1.97. [DOI] [PubMed] [Google Scholar]
  7. FOWLER M., SIMPSON D. A. A malignant melanin-forming tumour of the cerebellum. J Pathol Bacteriol. 1962 Oct;84:307–311. [PubMed] [Google Scholar]
  8. Frank G. L., Koten J. W. Melanotic hamartoma ("retinal anlage tumour") of the epididymis. J Pathol Bacteriol. 1967 Apr;93(2):549–554. doi: 10.1002/path.1700930215. [DOI] [PubMed] [Google Scholar]
  9. HODSON J. J. An intra-osseous tumour combination of biological importance-invasion of a melanotic schwannoma by an adamantinoma. J Pathol Bacteriol. 1961 Oct;82:257–266. [PubMed] [Google Scholar]
  10. Hahn J. F., Netsky M. G., Butler A. B., Sperber E. E. Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. J Neuropathol Exp Neurol. 1976 Jul;35(4):393–403. doi: 10.1097/00005072-197607000-00002. [DOI] [PubMed] [Google Scholar]
  11. Hahn J. F., Sperber E. E., Netsky M. G. Melanotic neuroectodermal tumors of the brain and skull. J Neuropathol Exp Neurol. 1976 Sep-Oct;35(5):508–519. doi: 10.1097/00005072-197609000-00003. [DOI] [PubMed] [Google Scholar]
  12. Hayward A. F., Fickling B. W., Lucas R. B. An electron microscope study of a pigmented tumour of the jaw of infants. Br J Cancer. 1969 Dec;23(4):702–708. doi: 10.1038/bjc.1969.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Holimon J. L., Rosenblum W. I. "Gangliorhabdomyosarcoma": a tumor of ectomesenchyme. Case report. J Neurosurg. 1971 Mar;34(3):417–422. doi: 10.3171/jns.1971.34.3.0417. [DOI] [PubMed] [Google Scholar]
  14. Johnston M. C. A radioautographic study of the migration and fate of cranial neural crest cells in the chick embryo. Anat Rec. 1966 Oct;156(2):143–155. doi: 10.1002/ar.1091560204. [DOI] [PubMed] [Google Scholar]
  15. KEEGAN H. R., MULLAN S. Pigmented meningiomas: an unusual variant. Report of a case with review of the litera ure. J Neurosurg. 1962 Aug;19:696–698. doi: 10.3171/jns.1962.19.8.0696. [DOI] [PubMed] [Google Scholar]
  16. KELLERT E., WOODRUFF R. Pigmented ganglionic tumor of the thorax. Cancer. 1956 Mar-Apr;9(2):300–305. doi: 10.1002/1097-0142(195603/04)9:2<300::aid-cncr2820090216>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  17. Karcioglu Z., Someren A., Mathes S. J. Ectomesenchymoma. A malignant tumor of migratory neural crest (ectomesenchyme) remnants showing ganglionic, schwannian, melanocytic and rhabdomyoblastic differentiation. Cancer. 1977 Jun;39(6):2486–2496. doi: 10.1002/1097-0142(197706)39:6<2486::aid-cncr2820390627>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  18. Lee S. C., Henry M. M., Gonzalez-Crussi F. Simultaneous occurrence of melanotic neuroectodermal tumor and brain heterotopia in the oropharynx. Cancer. 1976 Jul;38(1):249–253. doi: 10.1002/1097-0142(197607)38:1<249::aid-cncr2820380137>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  19. Lindahl F. Malignant melanotic progonoma. One case. Acta Pathol Microbiol Scand A. 1970;78(5):532–536. [PubMed] [Google Scholar]
  20. MISUGI K., OKAJIMA H., NEWTON W. A., Jr, KMETZ D. R., DELORIMIER A. A. MEDIASTINAL ORIGIN OF A MELANOTIC PROGONOMA OR RETINAL ANLAGE TUMOR: ULTRASTRUCTURAL EVIDENCE FOR NEURAL CREST ORIGIN. Cancer. 1965 Apr;18:477–484. doi: 10.1002/1097-0142(196504)18:4<477::aid-cncr2820180411>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  21. Mandybur T. I. Melanotic nerve sheath tumors. J Neurosurg. 1974 Aug;41(2):187–192. doi: 10.3171/jns.1974.41.2.0187. [DOI] [PubMed] [Google Scholar]
  22. McCloskey J. J., Parker J. C., Jr, Brooks W. H., Blacker H. M. Melanin as a component of cerebral gliomas: the melanotic cerebral ependymoma. Cancer. 1976 May;37(5):2373–2379. doi: 10.1002/1097-0142(197605)37:5<2373::aid-cncr2820370529>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  23. Naka A., Matsumoto S., Shirai T., Ito T. Ganglioneuroblastoma associated with malignant mesenchymoma. Cancer. 1975 Sep;36(3):1050–1056. doi: 10.1002/1097-0142(197509)36:3<1050::aid-cncr2820360331>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  24. RUBINSTEIN L. J., NORTHFIELD D. W. THE MEDULLOBLASTOMA AND THE SO-CALLED "ARACHNOIDAL CEREBELLAR SARCOMA". Brain. 1964 Jun;87:379–412. doi: 10.1093/brain/87.2.379. [DOI] [PubMed] [Google Scholar]
  25. SHUANGSHOTI S., ROBERTS M. P., NETSKY M. G. NEUROEPITHELIAL (COLLOID) CYSTS: PATHOGENESIS AND RELATION TO CHOROID PLEXUS AND EPENDYMA. Arch Pathol. 1965 Sep;80:214–224. [PubMed] [Google Scholar]
  26. Shillitoe A. J. Melanotic schwannoma. J Pathol Bacteriol. 1965 Oct;90(2):667–668. doi: 10.1002/path.1700900239. [DOI] [PubMed] [Google Scholar]
  27. Shuangshoti S., Chongchet V. Malignant mesenchymoma of ulnar nerve: combined sarcoma of nerve sheath and rhabdomyosarcoma. J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):524–528. doi: 10.1136/jnnp.42.6.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Shuangshoti S. Neoplasm of mixed mesenchymal and neuroepithelial origin: liposarcomatous meningioma combined with gliomas. J Neurol Neurosurg Psychiatry. 1973 Jun;36(3):377–382. doi: 10.1136/jnnp.36.3.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Shuangshoti S., Netsky M. G. Brain tumor of mixed mesenchymal and neuroepithelial origin. Case report. J Neurosurg. 1971 Jun;34(6):808–813. doi: 10.3171/jns.1971.34.6.0808. [DOI] [PubMed] [Google Scholar]
  30. Shuangshoti S., Netsky M. G. Choroid plexus and paraphysis in lower vertebrates. J Morphol. 1966 Oct;120(2):157–187. doi: 10.1002/jmor.1051200204. [DOI] [PubMed] [Google Scholar]
  31. Shuangshoti S., Netsky M. G. Histogenesis of choroid plexus in man. Am J Anat. 1966 Jan;118(1):283–316. doi: 10.1002/aja.1001180114. [DOI] [PubMed] [Google Scholar]
  32. Shuangshoti S., Netsky M. G. Human choroid plexus: morphologic and histochemical alterations with age. Am J Anat. 1970 May;128(1):73–95. doi: 10.1002/aja.1001280107. [DOI] [PubMed] [Google Scholar]
  33. Shuangshoti S., Netsky M. G., Jane J. A. Neoplasms of mixed mesenchymal and neuroepithelial type. With consideration of the relationship between meningioma and neurilemmoma. J Neurol Sci. 1971 Nov;14(3):277–291. doi: 10.1016/0022-510x(71)90217-6. [DOI] [PubMed] [Google Scholar]
  34. Shuangshoti S., Netsky M. G. Neoplasms of mixed mesenchymal and neuroepithelial origin. Relation to "monstrocellular sarcoma" or "giant-celled glioblastoma". J Neuropathol Exp Neurol. 1971 Apr;30(2):290–309. doi: 10.1097/00005072-197104000-00010. [DOI] [PubMed] [Google Scholar]
  35. Shuangshoti S., Netsky M. G., Switter D. J. Combined congenital vascular anomalies and neuroepithelial (colloid) cysts. Neurology. 1978 Jun;28(6):552–555. doi: 10.1212/wnl.28.6.552. [DOI] [PubMed] [Google Scholar]
  36. Shuangshoti S., Netsky M. G. Xanthogranuloma (xanthoma) of choroid plexus. The origin of foamy (xanthoma) cells. Am J Pathol. 1966 Mar;48(3):503–533. [PMC free article] [PubMed] [Google Scholar]
  37. Shuangshoti S., Paisuntornsook P., Netsky M. G. Melanosis of the choroid plexua. Neurology. 1976 Jul;26(7):656–658. doi: 10.1212/wnl.26.7.656. [DOI] [PubMed] [Google Scholar]
  38. Shuangshoti S., Paisuntornsook P., Netsky M. G. Melanosis of the choroid plexus, ependyma, subependymal neuroglia, and dentate and trigeminal motor nuclei: observations on the choroidal and ependymal cilia. Arch Pathol Lab Med. 1979 Mar;103(3):112–115. [PubMed] [Google Scholar]
  39. Shuangshoti S., Panyathanya R. Neoplasm of mixed mesenchymal and neuroepithelial origin of the optic nerve. Br J Ophthalmol. 1977 Jun;61(6):390–393. doi: 10.1136/bjo.61.6.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Shuangshoti S., Panyathanya R. Neural neoplasms in Thailand: a study of 2,897 cases. Neurology. 1974 Dec;24(12):1127–1134. doi: 10.1212/wnl.24.12.1127. [DOI] [PubMed] [Google Scholar]
  41. Shuangshoti S., Phisitbutr M., Kasantikul V., Netsky M. G. Multiple neuroepithelial (colloid) cysts: association with other congenital anomalies. Neurology. 1977 Jun;27(6):561–566. doi: 10.1212/wnl.27.6.561. [DOI] [PubMed] [Google Scholar]
  42. Shuangshoti S., Rungruxsirivorn S., Netsky M. G. Combined occurrence of mucin-producing ependymoma and neuroepithelial (colloid) cysts. J Neuropathol Exp Neurol. 1979 Jan;38(1):72–79. doi: 10.1097/00005072-197901000-00007. [DOI] [PubMed] [Google Scholar]
  43. Shuangshoti S., Samranvej P. Hypothalamic and pancreatic lesions with diabetes mellitus. J Neurol Neurosurg Psychiatry. 1975 Oct;38(10):1003–1007. doi: 10.1136/jnnp.38.10.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Shuangshoti S., Tangchai P., Netsky M. G. Primary adenocarcinoma of choroid plexus. Arch Pathol. 1971 Feb;91(2):101–106. [PubMed] [Google Scholar]
  45. Singer P. A., Cate J., Ross D. G., Netsky M. G. Melanosis of the dentate nucleus. Neurology. 1974 Feb;24(2):156–161. doi: 10.1212/wnl.24.2.156. [DOI] [PubMed] [Google Scholar]
  46. Stowens D., Lin T. H. Melanotic progonoma of the brain. Hum Pathol. 1974 Jan;5(1):105–113. doi: 10.1016/s0046-8177(74)80104-8. [DOI] [PubMed] [Google Scholar]
  47. Sung J. H., Mastri A. R., Segal E. L. Melanotic medulloblastoma of the cerebellum. J Neuropathol Exp Neurol. 1973 Jul;32(3):437–445. doi: 10.1097/00005072-197307000-00008. [DOI] [PubMed] [Google Scholar]
  48. TURNBULL I. M., TOM M. I. PIGMENTED MENINGIOMA. J Neurosurg. 1963 Jan;20:76–80. doi: 10.3171/jns.1963.20.1.0076. [DOI] [PubMed] [Google Scholar]
  49. Williams A. O. Melanotic ameloblastoma ("progonoma") of infancy showing osteogenesis. J Pathol Bacteriol. 1967 Apr;93(2):545–548. doi: 10.1002/path.1700930214. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES