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. 1980 Oct;43(10):861–865. doi: 10.1136/jnnp.43.10.861

Depression as a major symptom of multiple sclerosis.

F A Whitlock, M M Siskind
PMCID: PMC490704  PMID: 7441263

Abstract

Thirty patients suffering from multiple sclerosis have been compared with 30 patients suffering from other chronic neurological diseases. The degree of disability was similar in these two groups. The patients with multiple sclerosis had experienced more episodes of severe depression both before and after the onset of neurological symptoms. The possible reasons for these episodes are discussed and it is concluded that in some patients serious affective disorder may be a presenting or complicating feature of multiple sclerosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BECK A. T., WARD C. H., MENDELSON M., MOCK J., ERBAUGH J. An inventory for measuring depression. Arch Gen Psychiatry. 1961 Jun;4:561–571. doi: 10.1001/archpsyc.1961.01710120031004. [DOI] [PubMed] [Google Scholar]
  2. BIGNAMI A., GHERARDI D., GALLO G. [Acute multiple sclerosis with hypothalamic lozalization with melancholic symptomatology]. Riv Neurol. 1961 May-Jun;31:240–268. [PubMed] [Google Scholar]
  3. BRACELAND F. J., GIFFIN M. E. The mental changes associated with multiple sclerosis (an interim report). Res Publ Assoc Res Nerv Ment Dis. 1950;28:450–455. [PubMed] [Google Scholar]
  4. Burnfield A. Multiple sclerosis: a doctor's personal experience. Br Med J. 1977 Feb 12;1(6058):435–436. doi: 10.1136/bmj.1.6058.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CREMIEUX A., ALLIEZ J., TOGA M., PACHE R. [Multiple sclerosis with onset by mental disorders. Anatomo-clinical study]. Rev Neurol (Paris) 1959 Jul;101:45–51. [PubMed] [Google Scholar]
  6. Goodstein R. K., Ferrell R. B. Multiple sclerosis--presenting as depressive illness. Dis Nerv Syst. 1977 Feb;38(2):127–131. [PubMed] [Google Scholar]
  7. Kahana E., Leibowitz U., Alter M. Cerebral multiple sclerosis. Neurology. 1971 Dec;21(12):1179–1185. doi: 10.1212/wnl.21.12.1179. [DOI] [PubMed] [Google Scholar]
  8. Korsgaard S. Baclofen (Lioresal) in the treatment ofneuroleptic-induced tardive dyskinesia. Acta Psychiatr Scand. 1976 Jul;54(1):17–24. doi: 10.1111/j.1600-0447.1976.tb00090.x. [DOI] [PubMed] [Google Scholar]
  9. Můr J., Kümpel G., Dostál S. An anergic phase of disseminated sclerosis with psychotic course. Confin Neurol. 1966;28(1):37–49. doi: 10.1159/000103755. [DOI] [PubMed] [Google Scholar]
  10. O'Malley P. P. Severe mental symptoms in disseminated sclerosis, a neuro-pathological study. J Ir Med Assoc. 1966 Apr;58(346):115–127. [PubMed] [Google Scholar]
  11. Surridge D. An investigation into some psychiatric aspects of multiple sclerosis. Br J Psychiatry. 1969 Jul;115(524):749–764. doi: 10.1192/bjp.115.524.749. [DOI] [PubMed] [Google Scholar]
  12. Young A. C., Saunders J., Ponsford J. R. Mental change as an early feature of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):1008–1013. doi: 10.1136/jnnp.39.10.1008. [DOI] [PMC free article] [PubMed] [Google Scholar]

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