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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1980 Nov;43(11):1030–1034. doi: 10.1136/jnnp.43.11.1030

Folic acid and mental symptoms in children with epilepsy.

M R Trimble, J A Corbett, D Donaldson
PMCID: PMC490756  PMID: 7441279

Abstract

312 children resident at a hospital school received a neuropsychiatric examination and information was provided on their IQ status. Children with a fall in their IQ were identified. Serum and red cell folate values were estimated and the relationship between neuropsychiatric disturbances and folate disturbances explored. Patients with a fall in IQ, neurotic disturbance and depression all had significantly lower serum folic acid levels than the rest of the population, and the children with neurotic disturbances and depression had significantly lower red cell folate values. The relationship between folic acid metabolism and the neuropsychiatric disturbances is discussed in the light of these findings.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Callaghan N., Mitchell R., Cotter P. The relationship of serum folic acid and vitamin B 12 levels to psychosis in epilepsy. Ir J Med Sci. 1969 Oct;8(10):497–505. doi: 10.1007/BF02958622. [DOI] [PubMed] [Google Scholar]
  2. Carney M. W. Serum folate values in 423 psychiatric patients. Br Med J. 1967 Dec 2;4(5578):512–516. doi: 10.1136/bmj.4.5578.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carney M. W., Sheffield B. F. Serum folic acid and B12 in 272 psychiatric in-patients. Psychol Med. 1978 Feb;8(1):139–144. doi: 10.1017/s0033291700006711. [DOI] [PubMed] [Google Scholar]
  4. Grant R. H., Stores O. P. Folic acid in folate-deficient patients with epilepsy. Br Med J. 1970 Dec 12;4(5736):644–648. doi: 10.1136/bmj.4.5736.644. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hurdle A. D., Williams T. C. Folic-acid deficiency in elderly patients admitted to hospital. Br Med J. 1966 Jul 23;2(5507):202–205. doi: 10.1136/bmj.2.5507.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hällström T. Serum B12 and folate concentrations in mental patients. Acta Psychiatr Scand. 1969;45(1):19–36. doi: 10.1111/j.1600-0447.1969.tb06198.x. [DOI] [PubMed] [Google Scholar]
  7. Ibbotson R. N., Dilena B. A., Horwood J. M. Studies on deficiency and absorption of folates in patients on anticonvulsant drugs. Australas Ann Med. 1967 May;16(2):144–150. doi: 10.1111/imj.1967.16.2.144. [DOI] [PubMed] [Google Scholar]
  8. Jensen O. N., Olesen O. V. Folic acid concentrations in psychiatric patients. Acta Psychiatr Scand. 1969;45(3):289–294. doi: 10.1111/j.1600-0447.1969.tb07129.x. [DOI] [PubMed] [Google Scholar]
  9. Jensen O. N., Olesen O. V. Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates. Arch Neurol. 1970 Feb;22(2):181–182. doi: 10.1001/archneur.1970.00480200087010. [DOI] [PubMed] [Google Scholar]
  10. Kariks J., Perry S. W. Folic-acid deficiency in psychiatric patients. Med J Aust. 1970 Jun 13;1(24):1192–1195. doi: 10.5694/j.1326-5377.1970.tb84524.x. [DOI] [PubMed] [Google Scholar]
  11. Källström B., Nylöf R. Vitamin-B 12 and folic acid in psychiatric disorders. Acta Psychiatr Scand. 1969;45(2):137–152. doi: 10.1111/j.1600-0447.1969.tb10370.x. [DOI] [PubMed] [Google Scholar]
  12. Maxwell J. D., Hunter J., Stewart D. A., Ardeman S., Williams R. Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction? Br Med J. 1972 Jan 29;1(5795):297–299. doi: 10.1136/bmj.1.5795.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Melamed E., Reches A., Hershko C. Reversible central nervous system dysfunction in folate deficiency. J Neurol Sci. 1975 May;25(1):93–98. doi: 10.1016/0022-510x(75)90189-6. [DOI] [PubMed] [Google Scholar]
  14. Reynolds E. H. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol. 1976 Oct;5(3):661–696. [PubMed] [Google Scholar]
  15. Reynolds E. H., Preece J. M., Bailey J., Coppen A. Folate deficiency in depressive illness. Br J Psychiatry. 1970 Sep;117(538):287–292. [PubMed] [Google Scholar]
  16. Reynolds E. H., Preece J., Chanarin I. Folic acid and anticonvulsants. Lancet. 1969 Jun 21;1(7608):1264–1265. doi: 10.1016/s0140-6736(69)92144-8. [DOI] [PubMed] [Google Scholar]
  17. Reynolds E. H., Preece J., Johnson A. L. Folate metabolism in epileptic and psychiatric patients. J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):726–732. doi: 10.1136/jnnp.34.6.726. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reynolds E. H. Schizophrenia-like psychoses of epilepsy and disturbances of folate and vitamin B12 metabolism induced by anticonvulsant drugs. Br J Psychiatry. 1967 Aug;113(501):911–919. doi: 10.1192/bjp.113.501.911. [DOI] [PubMed] [Google Scholar]
  19. Shulman R. A survey of vitamin B-12 deficiency in an elderly psychiatric population. Br J Psychiatry. 1967 Mar;113(496):241–251. doi: 10.1192/bjp.113.496.241. [DOI] [PubMed] [Google Scholar]
  20. Snaith R. P., Mehta S., Raby A. H. Serum folate and vitamin B12 in epileptics with and without mental illness. Br J Psychiatry. 1970 Feb;116(531):179–183. doi: 10.1192/bjp.116.531.179. [DOI] [PubMed] [Google Scholar]
  21. Sneath P., Chanarin I., Hodkinson H. M., McPherson C. K., Reynolds E. H. Folate status in a geriatric population and its relation to dementia. Age Ageing. 1973 Aug;2(3):177–182. doi: 10.1093/ageing/2.3.177. [DOI] [PubMed] [Google Scholar]
  22. Thornton W. E., Thornton B. P. Folic acid, mental function, and dietary habits. J Clin Psychiatry. 1978 Apr;39(4):315-9, 322. [PubMed] [Google Scholar]
  23. Trimble M., Chadwick D., Reynolds E. H., Marsden C. D. Letter: L 5-Hydroxytryptophan and mood. Lancet. 1975 Mar 8;1(7906):583–583. doi: 10.1016/s0140-6736(75)91612-8. [DOI] [PubMed] [Google Scholar]

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