Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1980 Nov;43(11):1041–1044. doi: 10.1136/jnnp.43.11.1041

Astrocytic differentiation in medulloblastoma.

R O Barnard, H Pambakian
PMCID: PMC490758  PMID: 7441280

Abstract

A case of cerebellar medulloblastoma with transitional features towards malignant fibrillary astrocytoma is described. In the cerebellum the tumour is characterised by extensive subpial infiltration with cells of undifferentiated type, and the astrocytic component could only be identified by a positive glial fibrillary acidic protein reaction. In the brainstem the character of the growth transforms to that of diffuse astrocytoma. This demonstrates the potential for differentiation existing in a "primitive" neuroepithelial neoplasm.

Full text

PDF
1041

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Deck J. H., Eng L. F., Bigbee J., Woodcock S. M. The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Acta Neuropathol. 1978 Jun 30;42(3):183–190. doi: 10.1007/BF00690355. [DOI] [PubMed] [Google Scholar]
  2. Müller W., Schaefer H. E. Beitrag zur morphologischen Onkotypie des Medulloblastoms. Acta Neuropathol. 1974;30(1):51–61. doi: 10.1007/BF00685322. [DOI] [PubMed] [Google Scholar]
  3. Oppenheimer D. R. The effect of irradiation on a medulloblastoma. J Neurol Neurosurg Psychiatry. 1969 Apr;32(2):94–98. doi: 10.1136/jnnp.32.2.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Polak M. On the true nature of the so-called medulloblastoma. Acta Neuropathol. 1967 Mar 6;8(1):84–95. doi: 10.1007/BF00686653. [DOI] [PubMed] [Google Scholar]
  5. Rubinstein L. J., Herman M. M., Hanbery J. W. The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Light, electron microscopic, tissue, and organ culture observations. Cancer. 1974 Mar;33(3):675–690. doi: 10.1002/1097-0142(197403)33:3<675::aid-cncr2820330312>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES