Table 7.

AUPR for independent testing data (FDA approved, new drugs and experimental drugs)

Methods	Data-2	Data-3	Data-5
	new drugs	new targets	new drugs
k-NN	0.0783	0.1046	0.0173
BLM-svc	0.1064	0.1955	0.0316
BLM-svr	0.1263	0.2096	0.0405
LapRLS	0.1155	0.1454	0.0262
NetLapRLS	0.1244	0.1667	0.0278
WNN-GIP	0.1081	0.1680	0.0338
RF	0.1192	0.1314	0.0512
GBDT	0.1168	0.1577	0.0392
DrugE-Rank	0.1329	0.1810	0.0717
(DFV and TFV)
DrugE-Rank	0.1803	0.2658	0.0732
(PFV only)	(0.0123)	(0.0113)	(0.0029)
DrugE-Rank	$\mathbf{0}.\mathbf{2031}$	$\mathbf{0}.\mathbf{2831}$	$\mathbf{0}.\mathbf{0997}$
(all features)	(0.0127)	(0.0078)	(0.0205)