Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Apr;44(4):340–343. doi: 10.1136/jnnp.44.4.340

Rheological and fibrinolytic findings in multiple sclerosis.

A Brunetti, G L Ricchieri, G M Patrassi, A Girolami, B Tavolato
PMCID: PMC490958  PMID: 6972439

Abstract

Blood viscosity indices, fibrinolytic activity and other serum proteins related to haemocoagulation have been studied in 36 patients with multiple sclerosis. The whole blood viscosity was found to be increased in multiple sclerosis. The increase was caused by a decrease in erythrocyte deformability since plasma viscosity and haematocrit were normal. Plasminogen, fibrinogen and alpha 2 antitrypsin levels were found to be lower than normal. Such alterations were not observed in a group of patients with other non-immunological neurological diseases. In the latter group some coagulation indices were even higher than normal. The higher mean age of the pathological controls could explain the observed levels. The abnormalities observed in multiple sclerosis patients are considered to be a consequence of a non-specific activation of the coagulative system in a chronic immunological disease.

Full text

PDF
340

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON R. S., MILLAR J. H. Prevalence of disseminated sclerosis in Northern Ireland. Ulster Med J. 1954 Mar;23(Suppl 2):1–27. [PMC free article] [PubMed] [Google Scholar]
  2. Bowie E. J., Owen C. A., Jr The value of measuring platelet "adhesiveness" in the diagnosis of bleeding diseases. Am J Clin Pathol. 1973 Sep;60(3):302–308. doi: 10.1093/ajcp/60.3.302. [DOI] [PubMed] [Google Scholar]
  3. CLIFFTON E. E., CANNAMELA D. Fibrinolytic and proteolytic activity of a human plasminogen, prepared from fraction III of human plasma. J Appl Physiol. 1953 Jul;6(1):42–50. doi: 10.1152/jappl.1953.6.1.42. [DOI] [PubMed] [Google Scholar]
  4. Caspary E. A., Prineas J., Miller H., Field E. J. Platelet stickiness in multiple sclerosis. Lancet. 1965 Nov 27;2(7422):1108–1109. doi: 10.1016/s0140-6736(65)90068-1. [DOI] [PubMed] [Google Scholar]
  5. Davis L. E., Hersh E. M., Curtis J. E., Lynch R. E., Ziegler D. K., Neumann J. W., Chin T. D. Immune status of patients with multiple sclerosis. Analysis of primary and established immune responses in 24 patients. Neurology. 1972 Oct;22(10):989–997. doi: 10.1212/wnl.22.9.989. [DOI] [PubMed] [Google Scholar]
  6. Dohnal K., Vágner B., Lupínek Z., Hule V. Notes on the influence of adrenocorticotrophic hormone on platelet stickiness in multiple sclerosis. J Neurol Sci. 1971 Aug;13(4):443–446. doi: 10.1016/0022-510x(71)90006-2. [DOI] [PubMed] [Google Scholar]
  7. FIELD E. J., CASPARY E. A. BEHAVIOUR OF BLOOD-PLATELETS IN MULTIPLE SCLEROSIS. SOME OBSERVATIONS WITH A POSSIBLE BEARING ON PATHOGENESIS. Lancet. 1964 Oct 24;2(7365):876–879. doi: 10.1016/s0140-6736(64)90736-6. [DOI] [PubMed] [Google Scholar]
  8. Girolami A., Patrassi G., Bova G. No change of whole blood of plasma viscosity in cardiac patients after subcutaneous calcium heparin. Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(3):391–399. [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. Meade T. W., North W. R., Chakrabarti R., Haines A. P., Stirling Y. Population-based distributions of haemostatic variables. Br Med Bull. 1977 Sep;33(3):283–288. doi: 10.1093/oxfordjournals.bmb.a071448. [DOI] [PubMed] [Google Scholar]
  11. Menon I. S., Dewar H. A., Newell D. J. Fibrinolytic activity of venous blood of patients with multiple sclerosis. Neurology. 1969 Jan;19(1):101–104. doi: 10.1212/wnl.19.1.101. [DOI] [PubMed] [Google Scholar]
  12. PROEWIG F. Eine neue Theorie zur Ursache der Multiplen Sklerose. Med Monatsschr. 1958 Nov;12(11):732–734. [PubMed] [Google Scholar]
  13. Trouillas P., Betuel H. Hypocomplementaemic and normocomplementaemic multiple sclerosis. Genetic determinism and association with specific HLA determinants (B18 and B7). J Neurol Sci. 1977 Jul;32(3):425–435. doi: 10.1016/0022-510x(77)90024-7. [DOI] [PubMed] [Google Scholar]
  14. WELLS R. E., Jr, DENTON R., MERRILL E. W. Measurement of viscosity of biologic fluids by cone plate viscometer. J Lab Clin Med. 1961 Apr;57:646–656. [PubMed] [Google Scholar]
  15. Wright H. P., Thompson R. H., Zilkha K. J. Platelet adhesiveness in multiple sclerosis. Lancet. 1965 Nov 27;2(7422):1109–1110. doi: 10.1016/s0140-6736(65)90069-3. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES