Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Apr;44(4):347–351. doi: 10.1136/jnnp.44.4.347

The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome).

A J Lees, R Bannister
PMCID: PMC490960  PMID: 7241162

Abstract

In a controlled trial lisuride, an ergolene derivative with dopamine receptor agonist properties was given maximum tolerated doses (2.4 mg/day) to seven patients with multiple system atrophy with autonomic failure (Shy-Drager syndrome). Improvement in Parkinsonian features occurred in only one patient and another patient who had been deriving marked benefit from levodopa treatment before the study began failed to respond to large doses of lisuride. Psychiatric side effects (including nightmares, isolated visual hallucinations and toxic confusional states) were the dose-limiting factor in six patients. A modest reduction in orthostatic hypotension occurred in two patients, one of whom had experienced an aggravation of this disturbance on levodopa and bromocriptine. Destruction of post-synaptic dopamine receptors and damage to central noradrenergic systems may offer an explanation for the lack of therapeutic effect of lisuride.

Full text

PDF
347

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aminoff M. J., Wilcox C. S., Woakes M. M., Kremer M. Levodopa therapy for Parkinsonism in the Shy-Drager syndrome. J Neurol Neurosurg Psychiatry. 1973 Jun;36(3):350–353. doi: 10.1136/jnnp.36.3.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bannister R., Oppenheimer D. R. Degenerative diseases of the nervous system associated with autonomic failure. Brain. 1972;95(3):457–474. doi: 10.1093/brain/95.3.457. [DOI] [PubMed] [Google Scholar]
  3. Boudin G., Guillard A., Mikol J., Galle P. Dégénérescence striato-nigrique. A propos de l'étude clinique, thérapeutique et anatomique de 2 cas. Rev Neurol (Paris) 1976 Feb;132(2):137–156. [PubMed] [Google Scholar]
  4. Calne D. B., Stern G. M., Laurence D. R., Sharkey J., Armitage P. L-dopa in postencephalitic parkinsonism. Lancet. 1969 Apr 12;1(7598):744–746. doi: 10.1016/s0140-6736(69)91751-6. [DOI] [PubMed] [Google Scholar]
  5. De Lean J., Deck J. H. Shy-Drager syndrome. Neuropathological correlation and response to levodopa therapy. Can J Neurol Sci. 1976 Aug;3(3):167–173. doi: 10.1017/s0317167100025695. [DOI] [PubMed] [Google Scholar]
  6. Feve J. R., Mussini J. M., Mathé J. F., Cler J. M., Nomballais M. F. Dégénérescence striato-nigrique. Etude clinique et anatomique d'un cas ayant réagi très favorablement à la L-Dopa. Rev Neurol (Paris) 1977 Apr;133(4):271–278. [PubMed] [Google Scholar]
  7. Gautier J. C., Durand J. P. Traitement des syndromes parkinsoniens par la bromocriptine. Nouv Presse Med. 1977 Jan 22;6(3):171–174. [PubMed] [Google Scholar]
  8. Greer M., Collins G. H., Anton A. H. Cerebral catecholamines after levodopa therapy. Arch Neurol. 1971 Nov;25(5):461–467. doi: 10.1001/archneur.1971.00490050095008. [DOI] [PubMed] [Google Scholar]
  9. Henning M., Rubenson A. Central hypotensive effect of L-3,4-dihydroxyphenylalanine in the rat. J Pharm Pharmacol. 1970 Aug;22(8):553–560. doi: 10.1111/j.2042-7158.1970.tb10570.x. [DOI] [PubMed] [Google Scholar]
  10. Horowski R., Wachtel H. Direct dopaminergic action of lisuride hydrogen maleate, an ergot derivative, in mice. Eur J Pharmacol. 1976 Apr;36(2):373–383. doi: 10.1016/0014-2999(76)90091-1. [DOI] [PubMed] [Google Scholar]
  11. Horowski R., Wendt H., Gräf K. J. Prolactin-lowering effect of low doses of lisuride in man. Acta Endocrinol (Copenh) 1978 Feb;87(2):234–240. doi: 10.1530/acta.0.0870234. [DOI] [PubMed] [Google Scholar]
  12. Izumi K., Inoue N., Shirabe T., Miyazaki T., Kuroiwa Y. Failed levodopa therapy in striato-nigral degeneration. Lancet. 1971 Jun 26;1(7713):1355–1355. doi: 10.1016/s0140-6736(71)91914-3. [DOI] [PubMed] [Google Scholar]
  13. Johnson R. H., Lee G. de J., Oppenheimer D. R., Spalding J. M. Autonomic failure with orthostatic hypotension due to intermediolateral column degeneration. A report of two cases with autopsies. Q J Med. 1966 Apr;35(138):276–292. [PubMed] [Google Scholar]
  14. Kehr W. Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. Eur J Pharmacol. 1977 Feb 7;41(3):261–273. doi: 10.1016/0014-2999(77)90319-3. [DOI] [PubMed] [Google Scholar]
  15. Klawans H. L., Jr, Zeitlin E. L-dopa in Parkinsonism associated with cerebellar dysfunction (probable olivopontocerebellar degeneration). J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):14–19. doi: 10.1136/jnnp.34.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lance J. W. Simple formed hallucinations confined to the area of a specific visual field defect. Brain. 1976 Dec;99(4):719–734. doi: 10.1093/brain/99.4.719. [DOI] [PubMed] [Google Scholar]
  17. Lees A. J., Haddad S., Shaw K. M., Kohout L. J., Stern G. M. Bromocriptine in parkinsonism. A long-term study. Arch Neurol. 1978 Aug;35(8):503–505. doi: 10.1001/archneur.1978.00500320023005. [DOI] [PubMed] [Google Scholar]
  18. Michel D., Tommasi M., Laurent B., Trillet M., Schott B. Dégénérescence striato-nigrique. A propos de deux observations anatomo-cliniques. Rev Neurol (Paris) 1976 Jan;132(1):3–22. [PubMed] [Google Scholar]
  19. Quik M., Spokes E. G., Mackay A. V., Bannister R. Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease. J Neurol Sci. 1979 Nov;43(3):429–437. doi: 10.1016/0022-510x(79)90021-2. [DOI] [PubMed] [Google Scholar]
  20. Rajput A. H., Kazi K. H., Rozdilsky B. Striatonigral degeneration response to levodopa therapy. J Neurol Sci. 1972 Jul;16(3):331–341. doi: 10.1016/0022-510x(72)90196-7. [DOI] [PubMed] [Google Scholar]
  21. Rajput A. H., Rozdilsky B. Dysautonomia in Parkinsonism: a clinicopathological study. J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1092–1100. doi: 10.1136/jnnp.39.11.1092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. SHY G. M., DRAGER G. A. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol. 1960 May;2:511–527. doi: 10.1001/archneur.1960.03840110025004. [DOI] [PubMed] [Google Scholar]
  23. Schachter M., Blackstock J., Dick J. P., George R. J., Marsden C. D., Parkes J. D. Lisuride in Parkinson's disease. Lancet. 1979 Nov 24;2(8152):1129–1129. doi: 10.1016/s0140-6736(79)92523-6. [DOI] [PubMed] [Google Scholar]
  24. Schober R., Langston J. W., Forno L. S. Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases. Eur Neurol. 1975;13(3):177–188. doi: 10.1159/000114674. [DOI] [PubMed] [Google Scholar]
  25. Sharpe J. A., Rewcastle N. B., Lloyd K. G., Hornykiewicz O., Hill M., Tasker R. R. Striatonigral degeneration. Response to levodopa therapy with pathological and neurochemical correlation. J Neurol Sci. 1973 Jul;19(3):275–286. doi: 10.1016/0022-510x(73)90091-9. [DOI] [PubMed] [Google Scholar]
  26. Smith R. A., Gelles D. B., Vanderhaeghen J. J. Subcortical visual hallucinations. Cortex. 1971 Jun;7(2):162–168. doi: 10.1016/s0010-9452(71)80012-6. [DOI] [PubMed] [Google Scholar]
  27. Spokes E. G., Bannister R., Oppenheimer D. R. Multiple system atrophy with autonomic failure: clinical, histological and neurochemical observations on four cases. J Neurol Sci. 1979 Sep;43(1):59–82. doi: 10.1016/0022-510x(79)90073-x. [DOI] [PubMed] [Google Scholar]
  28. Steiner J. A., Low P. A., Huang C. Y., West M., Uther J. B., Allsop J. L., Chalmers J. P. L-dopa and the Shy-Drager syndrome. Med J Aust. 1974 Jul 27;2(4):133–136. doi: 10.5694/j.1326-5377.1974.tb93645.x. [DOI] [PubMed] [Google Scholar]
  29. Trotter J. L. Striatonigral degeneration, Alzheimer's disease, and inflammatory changes. Neurology. 1973 Nov;23(11):1211–1216. doi: 10.1212/wnl.23.11.1211. [DOI] [PubMed] [Google Scholar]
  30. Vanderhaeghen J. J., Périer O., Sternon J. E. Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson's disease. Arch Neurol. 1970 Mar;22(3):207–214. doi: 10.1001/archneur.1970.00480210017002. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES