Abstract
A clinical trial using the anti-depressant nomifensine in Parkinsonism is reported. Eighteen subjects not receiving levodopa participated. The drug had a small, but significant anti-Parkinsonian effect. No troublesome side effects were encountered. In the treatment of Parkinsonism, nomifensine may be considered as an alternative to amantadine or anticholinergics, especially where depression is an added feature.
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Selected References
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- Braestrup C., Scheel-Krüger J. Methylphenidate-like effects of the new antidepressant drug nomifensine (HOE 984). Eur J Pharmacol. 1976 Aug;38(2):305–312. doi: 10.1016/0014-2999(76)90333-2. [DOI] [PubMed] [Google Scholar]
- Costall B., Kelly D. M., Naylor R. J. Nomifensine: a potent dopaminergic agonist of antiparkinson potential. Psychopharmacologia. 1975;41(2):153–164. doi: 10.1007/BF00421073. [DOI] [PubMed] [Google Scholar]
- Hunt P., Kannengiesser M., Raynaud J. Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum. J Pharm Pharmacol. 1974 May;26(5):370–371. doi: 10.1111/j.2042-7158.1974.tb09294.x. [DOI] [PubMed] [Google Scholar]
- Marsden C. D., Parkes J. D. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet. 1977 Feb 12;1(8007):345–349. doi: 10.1016/s0140-6736(77)91146-1. [DOI] [PubMed] [Google Scholar]
- Mindham R. H., Marsden C. D., Parkes J. D. Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychol Med. 1976 Feb;6(1):23–33. doi: 10.1017/s0033291700007467. [DOI] [PubMed] [Google Scholar]
- Rinne U. K. Recent advances in research on Parkinsonism. Acta Neurol Scand Suppl. 1978;67:77–113. [PubMed] [Google Scholar]
- Schacht U., Heptner W. Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes. Biochem Pharmacol. 1974 Dec 15;23(24):3413–3422. doi: 10.1016/0006-2952(74)90344-x. [DOI] [PubMed] [Google Scholar]
- Schacht U., Leven M., Bäcker G. Studies on brain metabolism of biogenic amines. Br J Clin Pharmacol. 1977;4(Suppl 2):77S–87S. doi: 10.1111/j.1365-2125.1977.tb05763.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Teychenne P. F., Park D. M., Findley L. J., Rose F. C., Calne D. B. Nomifensine in parkinsonism. J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1219–1221. doi: 10.1136/jnnp.39.12.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]