Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Jul;44(7):570–573. doi: 10.1136/jnnp.44.7.570

Studies on erythrocyte membranes of patients with Huntington's disease

Thomas Mar Dubbelman 1,2, Adriaan W DE Bruijne 1,2, Johnny Van Steveninck 1,2, George W Bruyn 1,2
PMCID: PMC491060  PMID: 6270282

Abstract

Several red cell membrane properties and activities of membrane-bound enzymes were investigated in blood samples of patients with Huntington's disease. (Na++K+) ATPase activity and cell deformability appeared to be normal, in contradiction to preceding reports from other laboratories. With other techniques sensitive to relatively small changes in membrane structure, no abnormalities were found in Huntington's disease red cell membranes. These investigations do not support the concept that a generalised membrane abnormality is present in Huntington's disease.

Full text

PDF
570

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anker H. S. A solubilizable acrylamide gel for electrophoresis. FEBS Lett. 1970 Apr 16;7(3):293–293. doi: 10.1016/0014-5793(70)80185-5. [DOI] [PubMed] [Google Scholar]
  2. Bennett V., Branton D. Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin. J Biol Chem. 1977 Apr 25;252(8):2753–2763. [PubMed] [Google Scholar]
  3. Boivin P., Galand C. Isoelectric focusing of spectrin components in hereditary spherocytosis. Clin Chim Acta. 1976 Sep 6;71(2):165–171. doi: 10.1016/0009-8981(76)90527-1. [DOI] [PubMed] [Google Scholar]
  4. Burton A. C. Role of geometry, of size and shape, in the microcirculation. Fed Proc. 1966 Nov-Dec;25(6):1753–1760. [PubMed] [Google Scholar]
  5. Butterfield D. A., Oeswein J. Q., Markesbery W. R. Electron spin resonance study of membrane protein alterations in erythrocytes in Huntington's disease. Nature. 1977 Jun 2;267(5610):453–455. doi: 10.1038/267453a0. [DOI] [PubMed] [Google Scholar]
  6. Butterfield D. A., Purdy M. J., Markesbery W. R. Electron spin resonance, hematological, and deformability studies of erythrocytes from patients with Huntington's disease. Biochim Biophys Acta. 1979 Mar 8;551(2):452–458. doi: 10.1016/0005-2736(89)90020-5. [DOI] [PubMed] [Google Scholar]
  7. Cassiman J. J., Verlinden J., Vlietinck R. F., Bellemans J., Van Leuven F., Deroover J., Baro F., Van den Berghe H. Qualitative and quantitative study of the growth and cell surface properties of Huntington's disease fibroblasts and age-matched controls. Lack of significant differences. Hum Genet. 1979;53(1):75–86. doi: 10.1007/BF00289454. [DOI] [PubMed] [Google Scholar]
  8. Dubbelman T. M., de Bruijne A. W., Christianse K., van Steveninck J. Hypertonic cryohemolysis of human red blood cells. J Membr Biol. 1979 Nov 30;50(3-4):225–240. doi: 10.1007/BF01868890. [DOI] [PubMed] [Google Scholar]
  9. Fairbanks G., Steck T. L., Wallach D. F. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Biochemistry. 1971 Jun 22;10(13):2606–2617. doi: 10.1021/bi00789a030. [DOI] [PubMed] [Google Scholar]
  10. Green F. A., Jung C. Y. Cold-induced hemolysis in a hypertonic milieu. J Membr Biol. 1977 May 12;33(3-4):249–262. doi: 10.1007/BF01869519. [DOI] [PubMed] [Google Scholar]
  11. Hodson A., Pleasure D. Erythrocyte cation-activated adenosine triphosphatases in Duchenne muscular dystrophy. J Neurol Sci. 1977 Jul;32(3):361–369. doi: 10.1016/0022-510x(77)90019-3. [DOI] [PubMed] [Google Scholar]
  12. Hosey M. M., Tao M. An analysis of the autophosphorylation of rabbit and human erythrocyte membranes. Biochemistry. 1976 Apr 6;15(7):1561–1568. doi: 10.1021/bi00652a029. [DOI] [PubMed] [Google Scholar]
  13. Kirk D., Parrington J. M., Corney G., Bolt J. M. Anomalous cellular proliferation in vitro associated with Huntington's disease. Hum Genet. 1977 Apr 15;36(2):143–154. doi: 10.1007/BF00273252. [DOI] [PubMed] [Google Scholar]
  14. Markesbery W. R., Butterfield D. A. Scanning electron microscopy studies of erythrocytes in Huntington's disease. Biochem Biophys Res Commun. 1977 Sep 23;78(2):560–564. doi: 10.1016/0006-291x(77)90215-7. [DOI] [PubMed] [Google Scholar]
  15. Mély-Goubert B., Freedman M. H. Lipid fluidity and membrane protein monitoring using 1,6-diphenyl-1,3,5-hexatriene. Biochim Biophys Acta. 1980 Sep 18;601(2):315–327. doi: 10.1016/0005-2736(80)90536-2. [DOI] [PubMed] [Google Scholar]
  16. Mély-Goubert B., Freedman M. H. Membrane associated proteins and malignancy: an experimental hypothesis. Cancer Biochem Biophys. 1980;4(3):167–171. [PubMed] [Google Scholar]
  17. Pettegrew J. W., Nichols J. S., Stewart R. M. Fluorescence spectroscopy on Huntington's fibroblasts. J Neurochem. 1979 Oct;33(4):905–911. doi: 10.1111/j.1471-4159.1979.tb09920.x. [DOI] [PubMed] [Google Scholar]
  18. Pilwat G., Zimmermann U., Riemann F. Dielectric breakdown measurements of human and bovine erythrocyte membranes using benzyl alcohol as a probe molecule. Biochim Biophys Acta. 1975 Oct 17;406(3):424–432. doi: 10.1016/0005-2736(75)90021-8. [DOI] [PubMed] [Google Scholar]
  19. Riemann F., Zimmermann U., Pilwat G. Release and uptake of haemoglobin and ions in red blood cells induced by dielectric breakdown. Biochim Biophys Acta. 1975 Jul 3;394(3):449–462. doi: 10.1016/0005-2736(75)90296-5. [DOI] [PubMed] [Google Scholar]
  20. Weed R. I., LaCelle P. L., Merrill E. W. Metabolic dependence of red cell deformability. J Clin Invest. 1969 May;48(5):795–809. doi: 10.1172/JCI106038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. van Gastel L. F., van Steveninck J., de Bruijne A. W. The influence of anesthetics on red cell deformability. Biochem Biophys Res Commun. 1973 Dec 19;55(4):1240–1245. doi: 10.1016/s0006-291x(73)80027-0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES