Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Jul;44(7):608–614. doi: 10.1136/jnnp.44.7.608

Pattern-onset visual evoked potentials in suspected multiple sclerosis.

M J Aminoff, A L Ochs
PMCID: PMC491065  PMID: 7288448

Abstract

Visual evoked potentials (VEPs) were obtained by monocular stimulation using a checkerboard pattern-reversal and pattern-onset technique. In 11 normal subjects, pattern-onset VEPs were generally larger, better defined, and less ambiguous than those elicited by pattern-reversal, because of the biphasic waveform characteristically obtained with pattern-onset stimulation. In 68 of 105 patients with possible multiple sclerosis, VEPs were normal in latency by both methods, and in nine adequate comparison was not possible. The incidence of normal VEPs to pattern-reversal was similar to that found in several other studies of patients with possible multiple sclerosis. Among the remaining 28 patients in whom VEP abnormalities were found, an increased latency was detected in 75% with the pattern-reversal technique, and in 96% by pattern-onset. In these patients, VEP abnormalities were obtained by monocular stimulation of each of 46 eyes, and among these the pattern-reversal technique yielded abnormalities in 59% and the pattern-onset method in 98%. These results indicate that VEPs elicited by pattern-onset are useful in investigating patients with suspected multiple sclerosis, and the diagnostic yield may be greater than with conventional pattern-reversal techniques.

Full text

PDF
608

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asselman P., Chadwick D. W., Marsden D. C. Visual evoked responses in the diagnosis and management of patients suspected of multiple sclerosis. Brain. 1975 Jun;98(2):261–282. doi: 10.1093/brain/98.2.261. [DOI] [PubMed] [Google Scholar]
  2. Duwaer A. L., Spekreijse H. Latency of luminance and contrast evoked potentials in multiple sclerosis patients. Electroencephalogr Clin Neurophysiol. 1978 Aug;45(2):244–258. doi: 10.1016/0013-4694(78)90008-1. [DOI] [PubMed] [Google Scholar]
  3. Estévez O., Spekreijse H. Relationship between pattern appearance-disappearance and pattern reversal responses. Exp Brain Res. 1974 Feb 15;19(3):233–238. doi: 10.1007/BF00233231. [DOI] [PubMed] [Google Scholar]
  4. Halliday A. M., McDonald W. I., Mushin J. Delayed pattern-evoked responses in optic neuritis in relation to visual acuity. Trans Ophthalmol Soc U K. 1973;93(0):315–324. [PubMed] [Google Scholar]
  5. Halliday A. M., McDonald W. I., Mushin J. Delayed visual evoked response in optic neuritis. Lancet. 1972 May 6;1(7758):982–985. doi: 10.1016/s0140-6736(72)91155-5. [DOI] [PubMed] [Google Scholar]
  6. Halliday A. M., McDonald W. I., Mushin J. Visual evoked response in diagnosis of multiple sclerosis. Br Med J. 1973 Dec 15;4(5893):661–664. doi: 10.1136/bmj.4.5893.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Halliday A. M., Michael W. F. Changes in pattern-evoked responses in man associated with the vertical and horizontal meridians of the visual field. J Physiol. 1970 Jun;208(2):499–513. doi: 10.1113/jphysiol.1970.sp009134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Harter M. R., White C. T. Evoked cortical responses to checkerboard patterns: effect of check-size as a function of visual acuity. Electroencephalogr Clin Neurophysiol. 1970 Jan;28(1):48–54. doi: 10.1016/0013-4694(70)90007-6. [DOI] [PubMed] [Google Scholar]
  9. Hennerici M., Wenzel D., Freund H. J. The comparison of small-size rectangle and checkerboard stimulation for the evaluation of delayed visual evoked responses in patients suspected of multiple sclerosis. Brain. 1977 Mar;100(Pt 1):119–136. doi: 10.1093/brain/100.1.119. [DOI] [PubMed] [Google Scholar]
  10. Jeffreys D. A., Axford J. G. Source locations of pattern-specific components of human visual evoked potentials. I. Component of striate cortical origin. Exp Brain Res. 1972;16(1):1–21. doi: 10.1007/BF00233371. [DOI] [PubMed] [Google Scholar]
  11. Jeffreys D. A., Axford J. G. Source locations of pattern-specific components of human visual evoked potentials. II. Component of extrastriate cortical origin. Exp Brain Res. 1972;16(1):22–40. doi: 10.1007/BF00233372. [DOI] [PubMed] [Google Scholar]
  12. Lehmann D., Skrandies W. Reference-free identification of components of checkerboard-evoked multichannel potential fields. Electroencephalogr Clin Neurophysiol. 1980 Jun;48(6):609–621. doi: 10.1016/0013-4694(80)90419-8. [DOI] [PubMed] [Google Scholar]
  13. Meienberg O., Kutak L., Smolenski C., Ludin H. P. Pattern reversal evoked cortical responses in normals. A study of different methods of stimulation and potential reproducibility. J Neurol. 1979;222(2):81–93. doi: 10.1007/BF00313002. [DOI] [PubMed] [Google Scholar]
  14. Milner B. A., Regan D., Heron J. R. Differential diagnosis of multiple sclerosis by visual evoked potential recording. Brain. 1974 Dec;97(4):755–772. doi: 10.1093/brain/97.1.755. [DOI] [PubMed] [Google Scholar]
  15. Nilsson B. Y. Visual evoked responses in multiple sclerosis: comparison of two methods for pattern reversal. J Neurol Neurosurg Psychiatry. 1978 Jun;41(6):499–504. doi: 10.1136/jnnp.41.6.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ochs A. L., Aminoff M. J. The effect of adaptation to the stimulating pattern on the latency and wave form of visual evoked potentials. Electroencephalogr Clin Neurophysiol. 1980 May;48(5):502–508. doi: 10.1016/0013-4694(80)90285-0. [DOI] [PubMed] [Google Scholar]
  17. Padmos P., Haaijman J. J., Spekreuse H. Visually evoked cortical potentials to patterned stimuli in monkey and man. Electroencephalogr Clin Neurophysiol. 1973 Aug;35(2):153–163. doi: 10.1016/0013-4694(73)90171-5. [DOI] [PubMed] [Google Scholar]
  18. Shahrokhi F., Chiappa K. H., Young R. R. Pattern shift visual evoked responses. Two hundred patients with optic neuritis and/or multiple sclerosis. Arch Neurol. 1978 Feb;35(2):65–71. doi: 10.1001/archneur.1978.00500260003001. [DOI] [PubMed] [Google Scholar]
  19. Wilson W. B., Keyser R. B. Comparison of the pattern and diffuse-light visual evoked responses in definite multiple sclerosis. Arch Neurol. 1980 Jan;37(1):30–34. doi: 10.1001/archneur.1980.00500500060008. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES