Abstract
Ventricular volumes have been measured from CT scans of patients with benign intracranial hypertension both at initial presentation and at a later date. Volumes initially were smaller than normal, but at review five patients showed a significant increase in ventricular size. Persisting small ventricular volume correlated with persisting symptoms and signs and with persisting obesity. This supports the view that patients with benign intracranial hypertension have brain swelling and that obesity may be implicated in the pathogenesis, perhaps via a neuroendocrine disturbance. It is suggested that weight reduction may be an important component of treatment.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- FOLEY J. Benign forms of intracranial hypertension; toxic and otitic hydrocephalus. Brain. 1955;78(1):1–41. doi: 10.1093/brain/78.1.1. [DOI] [PubMed] [Google Scholar]
- Johnston I. Reduced C.S.F. absorption syndrome. Reappraisal of benign intracranial hypertension and related conditions. Lancet. 1973 Aug 25;2(7826):418–421. doi: 10.1016/s0140-6736(73)92277-0. [DOI] [PubMed] [Google Scholar]
- Penn R. D. Cerebral edema and neurological function in human beings. Neurosurgery. 1980 Mar;6(3):249–254. doi: 10.1227/00006123-198003000-00004. [DOI] [PubMed] [Google Scholar]
- Raichle M. E., Eichling J. O., Straatmann M. G., Welch M. J., Larson K. B., Ter-Pogossian M. M. Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water. Am J Physiol. 1976 Feb;230(2):543–552. doi: 10.1152/ajplegacy.1976.230.2.543. [DOI] [PubMed] [Google Scholar]
- Raichle M. E., Grubb R. L., Eichling J. O. Central neuroendocrine regulation of brain water permeability. Ciba Found Symp. 1978 Mar;(56):219–235. doi: 10.1002/9780470720370.ch12. [DOI] [PubMed] [Google Scholar]
- Raichle M. E., Hartman B. K., Eichling J. O., Sharpe L. G. Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3726–3730. doi: 10.1073/pnas.72.9.3726. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid A. C., Matheson M. S., Teasdale G. Volume of the ventricles in benign intracranial hypertension. Lancet. 1980 Jul 5;2(8184):7–8. doi: 10.1016/s0140-6736(80)92889-5. [DOI] [PubMed] [Google Scholar]
- Weisberg L. A. Benign intracranial hypertension. Medicine (Baltimore) 1975 May;54(3):197–207. doi: 10.1097/00005792-197505000-00002. [DOI] [PubMed] [Google Scholar]
- Weisberg L., Nice C. N. Computed tomographic evaluation of increased intracranial pressure without localizing signs. Radiology. 1977 Jan;122(1):133–136. doi: 10.1148/122.1.133. [DOI] [PubMed] [Google Scholar]
- Wyper D. J., Pickard J. D., Matheson M. Accuracy of ventricular volume estimation. J Neurol Neurosurg Psychiatry. 1979 Apr;42(4):345–350. doi: 10.1136/jnnp.42.4.345. [DOI] [PMC free article] [PubMed] [Google Scholar]