Abstract
Greyhound dogs exposed to oral acrylamide for a period of eight weeks developed a sensorimotor peripheral neuropathy that had many features in common with acrylamide neuropathy seen in other species. Most of the animals also developed the clinical and radiological features of megaoesophagus. The association of neuropathy and megaoesophagus suggests that an axonopathy of the vagus may be an aetiological factor in this disorder.
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- Clifford D. H., Lee M. O., Byun K. W., Lee D. C. Effects of autonomic drugs on the cardiovascular system: dogs with achalasia (under halothane anesthesia). Am J Vet Res. 1977 Mar;38(3):323–328. [PubMed] [Google Scholar]
- Duncan I. D., Griffiths I. R. Canine giant axonal neuropathy. Vet Rec. 1977 Nov 26;101(22):438–441. doi: 10.1136/vr.101.22.438. [DOI] [PubMed] [Google Scholar]
- Garland T. O., Patterson M. W. Six cases of acrylamide poisoning. Br Med J. 1967 Oct 28;4(5572):134–138. doi: 10.1136/bmj.4.5572.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gray G. W. Acute experiments on neuroeffector function in canine esophageal achalasia. Am J Vet Res. 1974 Aug;35(8):1075–1081. [PubMed] [Google Scholar]
- HARRIS L. D., ASHWORTH W. D., INGELFINGER F. J. Esophageal aperistalsis and achalasia produced in dogs by prolonged cholinesterase inhibition. J Clin Invest. 1960 Nov;39:1744–1751. doi: 10.1172/JCI104197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harvey C. E., O'Brien J. A., Durie V. R., Miller D. J., Veenema R. Megaesophagus in the dog: a clinical survey of 79 cases. J Am Vet Med Assoc. 1974 Sep 1;165(5):443–446. [PubMed] [Google Scholar]
- Higgs B., Kerr F. W., Ellis F. H., Jr The experimental production of esophageal achalasia by electrolytic lesions in the medulla. J Thorac Cardiovasc Surg. 1965 Nov;50(5):613–625. [PubMed] [Google Scholar]
- Hopkins A. The effect of acrylamide on the peripheral nervous system of the baboon. J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):805–816. doi: 10.1136/jnnp.33.6.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Janssens J., Valembois P., Vantrappen G., Hellemans J., Pelemans W. Is the primary peristaltic contraction of the canine esophagus bolus-dependent? Gastroenterology. 1973 Nov;65(5):750–756. [PubMed] [Google Scholar]
- Le Quesne P. M. Neurotoxic substances. Mod Trends Neurol. 1975;6:83–97. [PubMed] [Google Scholar]
- MORGAN J. P., LUMB W. V. ACHALASIA OF THE ESOPHAGUS IN THE DOG. J Am Vet Med Assoc. 1964 Apr 1;144:722–726. [PubMed] [Google Scholar]
- Pearson H. The differential diagnosis of persistent vomiting in the young dog. J Small Anim Pract. 1970 Jun;11(6):403–415. doi: 10.1111/j.1748-5827.1970.tb05438.x. [DOI] [PubMed] [Google Scholar]
- Post E. J., McLeod J. G. Acrylamide autonomic neuropathy in the cat. Part 1. Neurophysiological and histological studies. J Neurol Sci. 1977 Sep;33(3):353–374. doi: 10.1016/0022-510x(77)90133-2. [DOI] [PubMed] [Google Scholar]
- Prineas J. The pathogenesis of dying-back polyneuropathies. I. An ultrastructural study of experimental tri-ortho-cresyl phosphate intoxication in the cat. J Neuropathol Exp Neurol. 1969 Oct;28(4):571–597. doi: 10.1097/00005072-196910000-00003. [DOI] [PubMed] [Google Scholar]
- Prineas J. The pathogenesis of dying-back polyneuropathies. II. An ultrastructural study of experimental acrylamide intoxication in the cat. J Neuropathol Exp Neurol. 1969 Oct;28(4):598–621. doi: 10.1097/00005072-196910000-00004. [DOI] [PubMed] [Google Scholar]
- Spencer P. S., Schaumburg H. H. A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms. Can J Neurol Sci. 1974 Aug;1(3):152–169. doi: 10.1017/s0317167100119201. [DOI] [PubMed] [Google Scholar]
- Strombeck D. R., Troya L. Evaluation of lower motor neuron function in two dogs with megaesophagus. J Am Vet Med Assoc. 1976 Aug 15;169(4):411–414. [PubMed] [Google Scholar]
- Sumner A. J., Asbury A. K. Acrylamide neuropathy: selective vulnerability of sensory fibers. Trans Am Neurol Assoc. 1974;99:79–83. [PubMed] [Google Scholar]




