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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Oct;44(10):914–917. doi: 10.1136/jnnp.44.10.914

Rectal diazepam in the treatment of absence status: a pharmacodynamic study

Norman Milligan *, Soraya Dhillon , Alan Richens , Jolyon Oxley
PMCID: PMC491177  PMID: 7310409

Abstract

Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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