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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Neuropharmacology. 2016 Feb 24;107:58–67. doi: 10.1016/j.neuropharm.2016.02.027

Fig. 1.

Fig. 1

Intra-RMTg dermorphin–saporin substantially increases the intake of ethanol and the basal locomotor activity. The rats in DS-injected group, but not in BS- or vehicle-groups, robustly escalated the intake (A) and preference (B) for ethanol during 24 hours after the onset of drinking sections. Moreover, DS infusion reduced water intake (C), but did not affect the total fluid intake (D). However, intra-RMTg DS infusion did not alter the intake (E) and preference (F) for sucrose. (G), the mean total ambulation for rats injected with DS were substantially elevated compared with vehicle (100 nl/side, n = 9), BS (1.5 pmol/100nl/side, n = 9) at 2, 3, 4 and 5 weeks after intra-RMTg infusion. * p < 0.05, vs. both BS and vehicle; # p < 0.05, vs. BS group; ^ p < 0.05, vs. vehicle group, *$ p < 0.05, vs. baseline (two-way RM ANOVA followed by Tukey post hoc analysis), n = 9 rats in each group.