Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1982 Mar;45(3):257–260. doi: 10.1136/jnnp.45.3.257

Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases.

H Kuroda, N Ogawa, Y Yamawaki, I Nukina, T Ofuji, M Yamamoto, S Otsuki
PMCID: PMC491348  PMID: 7086447

Abstract

Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Behçet's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis.

Full text

PDF
257

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buryakova A. V., Sytinsky I. A. Amino acid composition of cerebrospinal fluid in actue neuroinfections in children. Arch Neurol. 1975 Jan;32(1):28–31. doi: 10.1001/archneur.1975.00490430050007. [DOI] [PubMed] [Google Scholar]
  2. DE ROBERTIS E., PELLEGRINO DE IRALDI A., RODRIGUEZ DE LORES GARNAIZ G., SALGANICOFF L. Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase. J Neurochem. 1962 Jan-Feb;9:23–35. doi: 10.1111/j.1471-4159.1962.tb07489.x. [DOI] [PubMed] [Google Scholar]
  3. Enna S. J. Neurobiology and pharmacology of Huntington's disease. Life Sci. 1977 Jan 15;20(2):205–211. doi: 10.1016/0024-3205(77)90314-9. [DOI] [PubMed] [Google Scholar]
  4. Enna S. J., Snyder S. H. A simple, sensitive and specific radioreceptor assay for endogenous GABA in brain tissue. J Neurochem. 1976 Jan;26(1):221–224. doi: 10.1111/j.1471-4159.1976.tb04465.x. [DOI] [PubMed] [Google Scholar]
  5. Fahn S., Côté L. J. Regional distribution of gamma-aminobutyric acid (GABA) in brain of the rhesus monkey. J Neurochem. 1968 Mar;15(3):209–213. doi: 10.1111/j.1471-4159.1968.tb06198.x. [DOI] [PubMed] [Google Scholar]
  6. Lloyd K. G., Hornykiewicz O. L-glutamic acid decarboxylase in Parkinson's disease: effect of L-dopa therapy. Nature. 1973 Jun 29;243(5409):521–523. doi: 10.1038/243521a0. [DOI] [PubMed] [Google Scholar]
  7. Manyam N. V., Hare T. A., Katz L., Glaeser B. S. Huntington's disease. Cerebrospinal fluid GABA levels in at-risk individuals. Arch Neurol. 1978 Nov;35(11):728–730. doi: 10.1001/archneur.1978.00500350032006. [DOI] [PubMed] [Google Scholar]
  8. Manyam N. V., Katz L., Hare T. A., Gerber J. C., 3rd, Grossman M. H. Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders. Arch Neurol. 1980 Jun;37(6):352–355. doi: 10.1001/archneur.1980.00500550054006. [DOI] [PubMed] [Google Scholar]
  9. Meldrum B. S. Epilepsy and gamma-aminobutyric acid-mediated inhibition. Int Rev Neurobiol. 1975;17:1–36. doi: 10.1016/s0074-7742(08)60205-6. [DOI] [PubMed] [Google Scholar]
  10. ROBERTS E., FRANKEL S. gamma-Aminobutyric acid in brain: its formation from glutamic acid. J Biol Chem. 1950 Nov;187(1):55–63. [PubMed] [Google Scholar]
  11. Roberts E., Kuriyama K. Biochemical-physiological correlations in studies of the gamma-aminobutyric acid system. Brain Res. 1968 Apr;8(1):1–35. doi: 10.1016/0006-8993(68)90170-4. [DOI] [PubMed] [Google Scholar]
  12. Robinson N., Wells F. Distribution and localization of sites of gamma aminobutyric acid metabolism in the adult rat brain. J Anat. 1973 Apr;114(Pt 3):365–378. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES