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. 2016 Mar 31;7:100–111. doi: 10.1016/j.ebiom.2016.03.037

Fig. 3.

Fig. 3.

Phase-shifting effects of acute palmitate (PAL) treatment on ensemble Bmal1-dLuc rhythms in cultured fibroblasts. (A) Representative recordings of ensemble bioluminescence from individual cultures of Bmal1-dLuc fibroblasts treated for 4 h with BSA (n = 5–6) or 250 μM PAL (n = 5–6) at hours 6, 12, 18 and 24. Red arrows indicate time of BSA or PAL treatment. (B) Time-dependent phase shifts (mean ± SEM) of fibroblast Bmal1-dLuc rhythms in response to PAL treatment at hours 6, 12, 18 and 24. The asterisk indicates that peak phase-shifting responses to PAL at hour 12 were significantly greater (p < 0.05) than those observed during the corresponding minima.