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. 2016 Jan 18;7(11):12761–12782. doi: 10.18632/oncotarget.6938

Figure 3. HMGA2 reduces telomere instability.

Figure 3

Anaphase bridges and micronuclei were quantified in three independent experiments (300 nuclei analyzed per experiment) and the average percentage of bridges and micronuclei per total of 900 analyzed nuclei is shown. Representative images of anaphase bridges in A. UTC8505 Mock clone 2, B. UTC8505 HMGA2 clone 4, C. C1+Dox and D. C1-No Dox fixed with 3.7% formaldehyde. E. Quantification of the average percentage of anaphase bridges in UTC8505 Mock clone 2 and HMGA2 clone 4 under two different fixatives and F. in C1 fibrosarcoma −/+ Dox fixed with 3.7% formaldehyde Representative images of micronuclei in G. UTC8505 Mock clone 2, H. UTC8505 HMGA2 clone 4, I. C1+Dox and J. C1-No Dox Quantification of the average percentage of micronuclei K. in UTC8505 and L. in C1 −/+ Dox Quantitative data are shown as mean +/− SEM; *p<0.05, **p<0.01.