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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1982 Oct;45(10):866–869. doi: 10.1136/jnnp.45.10.866

Chronic idiopathic polyneuropathy treated with azathioprine.

B Pentland, G G Adams, C Mawdsley
PMCID: PMC491589  PMID: 6292370

Abstract

The results of azathioprine therapy in five patients with chronic progressive or relapsing idiopathic inflammatory polyneuropathy are described. In four patients a sustained improvement followed treatment and in the other patient azathioprine successfully replaced corticosteroid therapy. The improvement was often delayed for up to three months. The literature on the use of azathioprine in chronic polyneuropathy is reviewed. We suggest that there is a place for azathioprine treatment in patients with chronic idiopathic polyneuropathy resistant or intolerant to corticosteroid treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUSTIN J. H. Recurrent polyneuropathies and their corticosteroid treatment; with five-year observations of a placebo-controlled case treated with corticotrophin, cortisone, and prednisone. Brain. 1958 Jun;81(2):157–192. doi: 10.1093/brain/81.2.157. [DOI] [PubMed] [Google Scholar]
  2. Cendrowski W. Treatment of polyneuropathy with azathioprine and adrenal steroids. Acta Med Pol. 1977;18(2):147–156. [PubMed] [Google Scholar]
  3. Dalakas M. C., Engel W. K. Chronic relapsing (dysimmune) polyneuropathy: pathogenesis and treatment. Ann Neurol. 1981;9 (Suppl):134–145. doi: 10.1002/ana.410090719. [DOI] [PubMed] [Google Scholar]
  4. Dyck P. J., Lais A. C., Ohta M., Bastron J. A., Okazaki H., Groover R. V. Chronic inflammatory polyradiculoneuropathy. Mayo Clin Proc. 1975 Nov;50(11):621–637. [PubMed] [Google Scholar]
  5. Heathfield K., Dallos V. Treatment of polyneuropathy with azathioprine. Lancet. 1970 Nov 14;2(7681):1030–1031. doi: 10.1016/s0140-6736(70)92838-2. [DOI] [PubMed] [Google Scholar]
  6. Hughes R. A., Newsom-Davis J. M., Perkin G. D., Pierce J. M. Controlled trial prednisolone in acute polyneuropathy. Lancet. 1978 Oct 7;2(8093):750–753. doi: 10.1016/s0140-6736(78)92644-2. [DOI] [PubMed] [Google Scholar]
  7. Matthews W. B., Howell D. A., Hughes R. D. Relapsing corticosteroid-dependent polyneuritis. J Neurol Neurosurg Psychiatry. 1970 Jun;33(3):330–337. doi: 10.1136/jnnp.33.3.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pentland B. Azathioprine in chronic relapsing idiopathic polyneuropathy. Postgrad Med J. 1980 Oct;56(660):734–735. doi: 10.1136/pgmj.56.660.734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pollard J. D., King R. H., Thomas P. K. Recurrent experimental allergic neuritis. An electron microscope study. J Neurol Sci. 1975 Mar;24(3):365–383. doi: 10.1016/0022-510x(75)90257-9. [DOI] [PubMed] [Google Scholar]
  10. Prusiński A., Szulc-Kuberska J., Zawadzki Z. Przypadek przewlekłego zespołu Guillaina i Barrégo leczony pomyślnie azatiopryna. Wiad Lek. 1978 Nov 1;31(21):1545–1547. [PubMed] [Google Scholar]
  11. Sivaram C. A., Kapur S., Rao N. S., Chopra J. S. Infective polyneuritis treated with azathioprine (a case report). Neurol India. 1975 Jun;23(2):111–114. [PubMed] [Google Scholar]
  12. Swash M. Clinical aspects of Guillian-Barré syndrome: a review. J R Soc Med. 1979 Sep;72(9):670–673. doi: 10.1177/014107687907200909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thomas P. K., Lascelles R. G., Hallpike J. F., Hewer R. L. Recurrent and chronic relapsing Guillain-Barré polyneuritis. Brain. 1969;92(3):589–606. doi: 10.1093/brain/92.3.589. [DOI] [PubMed] [Google Scholar]
  14. Walker G. L. Progressive polyradiculoneuropathy: treatment with Azathioprine. Aust N Z J Med. 1979 Apr;9(2):184–187. doi: 10.1111/j.1445-5994.1979.tb04326.x. [DOI] [PubMed] [Google Scholar]
  15. Yuill G. M., Swinburn W. R., Liversedge L. A. Treatment of polyneuropathy with azathioprine. Lancet. 1970 Oct 24;2(7678):854–856. doi: 10.1016/s0140-6736(70)92019-2. [DOI] [PubMed] [Google Scholar]

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