Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1982 Nov;45(11):969–974. doi: 10.1136/jnnp.45.11.969

A controlled study of dementia in Parkinson's disease.

R H Mindham, S W Ahmed, C G Clough
PMCID: PMC491631  PMID: 7175541

Abstract

Tests of cognitive functions were carried out in a group of patients with Parkinson's disease and repeated after a three-year interval. Comparison was made with a control group drawn from a population of psychiatric patients, matched for age and sex. No differences in cognitive functions were found between the groups, either initially, or between those surviving for three years. Deaths among the index group included a high proportion of patients with cognitive impairment and there was an increasing prevalence and severity of dementia in the index group which exceeded that observed in the control group. Requirements for a methodologically sound study of dementia in Parkinson's disease are discussed.

Full text

PDF
969

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albert M. L., Feldman R. G., Willis A. L. The 'subcortical dementia' of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 1974 Feb;37(2):121–130. doi: 10.1136/jnnp.37.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Asso D. W.A.I.S. scores in a group of Parkinson patients. Br J Psychiatry. 1969 May;115(522):555–556. doi: 10.1192/bjp.115.522.555. [DOI] [PubMed] [Google Scholar]
  3. Bowen D. M., Davison A. N. Letter: Extrapyramidal diseases and dementia. Lancet. 1975 May 24;1(7917):1199–1200. doi: 10.1016/s0140-6736(75)93192-x. [DOI] [PubMed] [Google Scholar]
  4. Bowen F. P., Kamienny R. S., Burns M. M., Yahr M. Parkinsonism: effects of levodopa treatment on concept formation. Neurology. 1975 Aug;25(8):701–704. doi: 10.1212/wnl.25.8.701. [DOI] [PubMed] [Google Scholar]
  5. Celesia G. G., Wanamaker W. M. Psychiatric disturbances in Parkinson's disease. Dis Nerv Syst. 1972 Sep;33(9):577–583. [PubMed] [Google Scholar]
  6. Garron D. C., Klawans H. L., Jr, Narin F. Intellectual functioning of persons with idiopathic Parkinsonism. J Nerv Ment Dis. 1972 Jun;154(6):445–452. doi: 10.1097/00005053-197206000-00007. [DOI] [PubMed] [Google Scholar]
  7. Hakim A. M., Mathieson G. Dementia in Parkinson disease: a neuropathologic study. Neurology. 1979 Sep;29(9 Pt 1):1209–1214. doi: 10.1212/wnl.29.9_part_1.1209. [DOI] [PubMed] [Google Scholar]
  8. Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
  9. Lieberman A., Dziatolowski M., Kupersmith M., Serby M., Goodgold A., Korein J., Goldstein M. Dementia in Parkinson Disease. Ann Neurol. 1979 Oct;6(4):355–359. doi: 10.1002/ana.410060409. [DOI] [PubMed] [Google Scholar]
  10. Loranger A. W., Goodell H., McDowell F. H., Lee J. E., Sweet R. D. Intellectual impairment in Parkinson's syndrome. Brain. 1972;95(2):405–412. doi: 10.1093/brain/95.2.405. [DOI] [PubMed] [Google Scholar]
  11. Marttila R. J., Rinne U. K. Dementia in Parkinson's disease. Acta Neurol Scand. 1976 Nov;54(5):431–441. doi: 10.1111/j.1600-0404.1976.tb04375.x. [DOI] [PubMed] [Google Scholar]
  12. Matthews C. G., Haaland K. Y. The effect of symptom duration on cognitive and motor performance in parkinsonism. Neurology. 1979 Jul;29(7):951–956. doi: 10.1212/wnl.29.7.951. [DOI] [PubMed] [Google Scholar]
  13. Mayeux R., Stern Y., Rosen J., Leventhal J. Depression, intellectual impairment, and Parkinson disease. Neurology. 1981 Jun;31(6):645–650. doi: 10.1212/wnl.31.6.645. [DOI] [PubMed] [Google Scholar]
  14. Mindham R. H., Marsden C. D., Parkes J. D. Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychol Med. 1976 Feb;6(1):23–33. doi: 10.1017/s0033291700007467. [DOI] [PubMed] [Google Scholar]
  15. Mindham R. H. Psychiatric symptoms in Parkinsonism. J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):188–191. doi: 10.1136/jnnp.33.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mortimer J. A., Pirozzolo F. J., Hansch E. C., Webster D. D. Relationship of motor symptoms to intellectual deficits in Parkinson disease. Neurology. 1982 Feb;32(2):133–137. doi: 10.1212/wnl.32.2.133. [DOI] [PubMed] [Google Scholar]
  17. Pollock M., Hornabrook R. W. The prevalence, natural history and dementia of Parkinson's disease. Brain. 1966 Sep;89(3):429–448. doi: 10.1093/brain/89.3.429. [DOI] [PubMed] [Google Scholar]
  18. Reitan R. M., Boll T. J. Intellectual and cognitive functions in Parkinson's disease. J Consult Clin Psychol. 1971 Dec;37(3):364–369. doi: 10.1037/h0032005. [DOI] [PubMed] [Google Scholar]
  19. Riklan M., Whelihan W., Cullinan T. Levodopa and psychometric test performance in parkinsonism-5 years later. Neurology. 1976 Feb;26(2):173–179. doi: 10.1212/wnl.26.2.173. [DOI] [PubMed] [Google Scholar]
  20. Shaw K. M., Lees A. J., Stern G. M. The impact of treatment with levodopa on Parkinson's disease. Q J Med. 1980;49(195):283–293. [PubMed] [Google Scholar]
  21. TALLAND G. A. Cognitive function in Parkinson's disease. J Nerv Ment Dis. 1962 Sep;135:196–205. [PubMed] [Google Scholar]
  22. Warburton J. W. Memory disturbance and the Parkinson syndrome. Br J Med Psychol. 1967 Jun;40(2):169–171. doi: 10.1111/j.2044-8341.1967.tb00566.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES